Protein losing nephropathy (PLN)

LABOKLIN Service ID: 8492

Hereditary PLN in the breeds Airedale Terrier and Irish Soft Coated Wheaten Terrier starts with a hidden proteinuria in midlife. The disease can proceed mildly and stay steady for years. In some cases severe complications like kidney failure or thromboses occur. Risk assessment for PLN is possible due to genetic testing, now. Nevertheless, starting point and development of symptoms vary hugely and are supposed to depend on enviromental factors and modifying genes. Additionally, aquired forms of PLN disease can not be detected by the genetic test.

Method	TaqMan SNP assay
Breed list	Airedale Terrier, Irish Soft Coated Wheaten Terrier
Heredity	Risk assessment: Heterozygous dogs possess medium risk, homozygous affected dogs possess high risk to develop symptoms of the disease.
Duration	3 - 5 days after arrival of the sample in the lab