Mitochondrial fission encephalopathy (MFE)

LABOKLIN Service ID: 8521

A mutation in the MFF gene causes Mitochondrial fission encephalopathy (MFE) in the breed Bullmastiff. Symptoms in homozygously affected dogs are ataxia, an uncoordinated gait and behavioural abnormalities. The symptoms already start at a very young age and are gradually progressing. Additional symptoms are a wide base stance posture and decreased vision. A neurological examination suggested a disease of the cerebral cortex and the vestibulo-cerebellum and MRI confirmed cerebellar alterations.

Method	sequencing
Breed list	Bullmastiff
Heredity	autosomal recessive
Duration	1 - 2 weeks after arrival of the sample in the lab