Maxillary canine tooth mesioversion (MCM)

LABOKLIN Service ID: 8819

A variant in the FTSJ3 gene is associated with dental anomaly and reduced body size in Shetland Sheepdogs. Affected dogs are characterized by reduced body height and weight as well as mesioversion of the maxilliary canine teeth (MCM). One or both maxillary canines may be affected and displaced towards the nose. MCM can induce traumatic occlusion, upper lip ulceration or periodontal diseases and may require extraction or orthodontic repositioning. The body size of dogs which are heterozygous for the risk allele is significantly higher compared to dogs which are homozygous for the risk allele. For dogs with two risk alleles there is a strong risk for MCM, for dogs with one copy the weight determines the risk, with lightweight dogs at higher risk.

Method	TaqMan SNP assay
Breed list	Shetland Sheepdog (Sheltie)
Heredity	autosomal dominant
Duration	3 - 5 days after arrival of the sample in the lab