Neuronal ceroid lipofuscinosis (NCL)

LABOKLIN Service ID: 8075

NCL is a neurodegenerative disease, caused by lysosomal storage dysfunction. The clinical course includes increasing levels of agitation and possible outbursts of aggression, hallucinations, hyperactivity and epileptic fits. Most animals lose their ability to coordinate everyday muscular activities. As the extent of neurodegeneration increases, all affected dogs develop psychological abnormalities and ataxia.

Method	TaqMan SNP assay, if necessary sequencing (American Bulldog, Border Collie, English Setter, Golden Retriever, Gordon Setter, Tibetan Terrier); Sequencing (Chinese Crested Dog, Chihuahua, Italian Cane Corso, Saluki)
Breed list	American Bulldog, Border Collie, Chihuahua, Chinese Crested Dog, English Setter, Golden Retriever, Gordon Setter, Italian Cane Corso, Saluki, Schapendoes, Small Swiss Hound, Tibetan Terrier
Heredity	autosomal recessive
Duration	3 - 5 days after arrival of the sample in the lap, in case of sequencing 1 - 2 weeks (American Bulldog, Border Collie, English Setter, Golden Retriever, Gordon Setter, Tibetan Terrier; 1 - 2 weeks (Chinese Crested Dog, Chihuahua, Italian Cane Corso, Saluki)