Upper airway syndrome (UAS)

LABOKLIN Service ID: 8391

The Norwich Terrier is considered to be a “mesocephalic” breed. While brachycephalic dogs are predisposed to the Brachycephalic Obstructive Airway Syndrome (BOAS), the Upper Airway Syndrome (UAS) could often be observed at dogs of the breed Norwich Terrier. Respiratory effort, resulting in laboured breathing, intolerance to heat or exercise, cyanosis and collapse are typical symptoms of both syndromes (UAS and BOAS).
In the breed Norwich Terrier, a variant in the ADAMTS3 gene could be found to be associated with the UAS. Homozygous affected dogs often show an elongated soft palate protruding caudally into the epiglottis, the laryngeal cartilage is inverted into the lumen of the airway and the laryngeal saccules are everted.

Method	sequencing
Breed list	Norwich Terrier
Heredity	autosomal recessive
Duration	1 - 2 weeks after arrival of the sample in the lab