Retinal dysplasia (OSD)

LABOKLIN Service ID: 8392

Retinal Folds, also called Retinal Dysplasia (RD), is observed in many dog breeds without any pathological consequence. However in the Labrador Retriever breed, Retinal Folds can be associated with a more severe syndrom, the OculoSkeletal Dysplasia (OSD). Clinical signs of OSD are skeletal malformations comprising shortened limbs (dwarfism) as well as blindness at early age. Blindness results from a partial or complete detachment of the retina and cataract due to a generalized malformation of the retina. The mode of inheritance is still not fully understood but an autosomal-dominant trait with incomplete penetrance is assumed.

Method	sequencing
Breed list	Australian-Labradoodle (Cobberdog), Labradoodle, Labrador Retriever
Heredity	autosomal dominant with incomplete penetrance
Duration	1 - 2 weeks after arrival of the sample in the lab