Neuronal ceroid lipofuscinosis (NCL)
LABOKLIN Service ID: 8133
NCL is a neurodegenerative disease, caused by lysosomal storage dysfunction.
The clinical course includes increasing levels of agitation and possible outbursts of aggression, hallucinations, hyperactivity and epileptic fits. Most animals lose their ability to coordinate everyday muscular activities. As the extent of neurodegeneration increases, all affected dogs develop psychological abnormalities and ataxia.
| Method | TaqMan SNP assay, if necessary sequencing (Australian Cattle Dog, Australian Shepherd, Miniature American Shepherd); sequencing (Dachshund) |
| Breed list | Australian Cattle Dog, Australian Shepherd, Dachshund (Dackel), Long-Haired Dachshund, Miniature American Shepherd, Short-Haired Dachshund, Wire-Haired Dachshund |
| Heredity | autosomal recessive |
| Duration | 3 - 5 days after arrival of the sample in the lap, in case of sequencing 1-2 weeks (Australian Cattle Dog, Australian Shepherd, Miniature American Shepherd); 1 – 2 weeks (Dachshund) |