Neuronal ceroid lipofuscinosis (NCL)

LABOKLIN Service ID: 8133

NCL is a neurodegenerative disease, caused by lysosomal storage dysfunction.
The clinical course includes increasing levels of agitation and possible outbursts of aggression, hallucinations, hyperactivity and epileptic fits. Most animals lose their ability to coordinate everyday muscular activities. As the extent of neurodegeneration increases, all affected dogs develop psychological abnormalities and ataxia.

Method

TaqMan SNP assay, if necessary sequencing (Australian Shepherd, Miniature American Shepherd) sequencing (Australian Cattle Dog)

Breed list

Australian Cattle Dog, Australian Shepherd, Miniature American Shepherd

Heredity

autosomal recessive

Duration

3 - 5 days after arrival of the sample in the lap, in case of sequencing 1-2 weeks (Australian Shepherd, Miniature American Shepherd); 1 – 2 weeks (Australian Cattle Dog)