Cone degeneration (CD)

LABOKLIN Service ID: 8780

A mutation in the gene CNGB3 leads to Cone Degeneration (CD) in German Short-haired Pointing Dogs. Cone degeneration is an inherited disease of the retina. In affected puppies cone cells already start to degenerate in the puppy-stage, leading to a distinct form of day blindness. First symptoms can be recognised at the age of about 8-12 weeks. Affected puppies avoid bright light, as those conditions can cause pain for the dog. Vision in dim light conditions or at night stays normal. Afterwards, symptoms increase as cone cell degeneration progresses over time.

Method	sequencing
Breed list	German Short-haired Pointing Dog
Heredity	autosomal recessive
Duration	1 - 2 weeks after arrival of the sample in the lab