Cleft lip/palate and syndactyly (CLPS)

LABOKLIN Service ID: 8326

Cleft lip/palate and syndactyly (CLPS) describes a hereditary diseasein Nova Scotia Duck Tolling Retrievers. Two different genetic defects were found to be the cause of this disease: One mutation is located in the gene CP1, another mutation is located in the gene ADAMTS20, which is responsible for similar syptoms in humans. Early on, affected puppies develop a cleft palate, cleft lips, as well as the pathological growth along the middle toes, which is called syndactyly.

Method

TaqMan SNP assay, if necessary sequencing

Breed list

Nova Scotia Duck Tolling Retriever

Heredity

autosomal recessive

Duration

3 - 5 days after arrival of the sample in the lap (in case of sequencing 1 - 2 weeks)