Cleft lip/palate and syndactyly (CLPS)
LABOKLIN Service ID: 8326
Cleft lip/palate and syndactyly (CLPS) describes a hereditary diseasein Nova Scotia Duck Tolling Retrievers. Two different genetic defects were found to be the cause of this disease: One mutation is located in the gene CP1, another mutation is located in the gene ADAMTS20, which is responsible for similar syptoms in humans. Early on, affected puppies develop a cleft palate, cleft lips, as well as the pathological growth along the middle toes, which is called syndactyly.
Method | TaqMan SNP assay, if necessary sequencing |
Breed list | Nova Scotia Duck Tolling Retriever |
Heredity | autosomal recessive |
Duration | 3 - 5 days after arrival of the sample in the lap (in case of sequencing 1 - 2 weeks) |