C3 deficiency (C3)

LABOKLIN Service ID: 8184

The third component (C3) of the complement system plays an important role in the immune response to microbes like bacteria, fungi or parasites. The causative mutation prohibits the formation of functional C3 units and the chain of defence mechanisms is broken. Affected dogs exhibit higher susceptibility to bacterial infections. Glomerulonephritis, caused by C3-deficiency dependant cell death in the complement system, is often diagnosed for those dogs.

Method	sequencing
Breed list	Brittany Spaniel
Heredity	autosomal recessive
Duration	1 - 2 weeks after srrival of the sample in the lab