Delayed postoperative hemorrhage (DEPOH)

LABOKLIN Service ID: 8862

A variant in the SERPINF2 gene has been identified in Scottish Deerhounds and Greyhounds that is associated with an increased risk of developing delayed postoperative hemorrhage (DEPOH). Clinical signs are the unexpected, excessive bleeding or bruising starting 1 to 4 days after a surgical procedure. The symptoms vary from frank bleeding from the wound, to excessive and also progressive bruising of the skin surrounding the wound and hemoabdomen. The results of coagulation screening tests like the measurements of prothrombin time, activated partial thromboplastin time and von Willebrand factor antigen, as well as platelet counts were unremarkable.
Compared to dogs not carrying the marker variant, dogs with two variant alleles as well as dogs with one variant allele show an increased risk of developing DEPOH.

Method	sequencing
Breed list	Deerhound, Greyhound
Heredity	autosomal dominant with incomplete penetrance
Duration	1 - 2 weeks after arrival of the sample in the lab