Neuroaxonal dystrophy (NAD)

LABOKLIN Service ID: 8308

The neuroaxonal dystrophy (NAD) is characterised by a histologically distinct neurodegenerative pathology of the central and/or peripheral nervous system. As with most neurological disorders, symptoms may vary and the disease itself is therefore diagnostically nonspecific. The onset of the disease takes place in early development.
In dogs, late-gestational fetal akinesia, multiple joint fixation and pulmonary hypoplasie are found in animals which are homozygous for the mutated allele. Those puppies die at birth due to respiratory failure and exhibit swollen axons and spheroids throughout the nervous system.

Method	TaqMan SNP assay, if necessary sequencing
Breed list	Lagotto Romagnolo, Miniature American Shepherd, Papillon, Rottweiler, Spanish Water Dog
Heredity	autosomal recessive
Duration	3 - 5 days after arrival of the sample in the lab (in case of sequencing 1 - 2 weeks)