Thymidine Kinase

LABOKLIN Service ID: 1038


serum 0.5 ml (cooled)



Species list

dog, cat, rabbit, guinea pig, ferret, horse, others on request


1 day


  • Thymidine kinase is an enzyme which helps introduce the nucleoside thymidine into the DNA by converting deoxythymidine to deoxythymidine phosphate (dTMP). It is thus essential for DNA synthesis.
  • The activity of serum thymidine kinase 1 (sTK1) correlates closely with DNA synthesis and cell proliferation. The main indications for the determination of thymidine kinase in malignant haematopoietic neoplasms are therapy monitoring and early detection of relapse.
  • Its concentration is a measure for the activity of cell division. Thymidine kinase is therefore used as a tumour marker. Elevated concentrations are primarily measured in malignant diseases of the haematopoietic and lymphatic system.
  • Thymidine kinase is mainly excreted renally. Therefore, if levels are increased, it is necessary to exclude impaired renal function in differential diagnosis.
  • Patients with hepatic cirrhosis may also show elevated concentrations.
  • Growing patients physiologically have higher concentrations.
  • Thymidine kinase is also part of the profile Tumour Diagnostics (see category Profiles, Small Animals and Horse, Biochemistry Profiles).