LABOKLIN Service ID: 1038
| Material | serum 0.5 ml (centrifuge, pipette off and cool soon after sampling) |
| Method | CLIA |
| Species list | dog, cat, rabbit, guinea pig, ferret, horse, others on request |
| Duration | 1 day |
| Remark | - Thymidine kinase is an enzyme which helps introduce the nucleoside thymidine into the DNA by converting deoxythymidine to deoxythymidine phosphate (dTMP). It is thus essential for DNA synthesis.
- The activity of serum thymidine kinase 1 (sTK1) correlates closely with DNA synthesis and cell proliferation. The main indications for the determination of thymidine kinase in malignant haematopoietic neoplasms are therapy monitoring and early detection of relapse.
- Thymidine kinase is mainly excreted renally. Therefore, if levels are increased, it is necessary to exclude impaired renal function in differential diagnosis.
- Patients with hepatic cirrhosis may also show elevated concentrations.
- Growing patients physiologically have higher concentrations.
- Thymidine kinase is also part of the profile Tumour Diagnostics (see category Profiles, Small Animals and Horse, Biochemistry Profiles).
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