Equine malignant hyperthermia (EMH)

LABOKLIN Service ID: 8160

Equine malignant hyperthermia (EMH) is a life-threatening pharmacogenetic disorder of skeletal muscle elicited by halogenated anesthetics, depolarizing muscle relaxants, and stress. Dysfunction of RyR1 (calcium release channel of the sarcoplasmic reticulum of skeletal muscle) results in excessive release of calcium into the myoplasm-triggering cascade events that lead to a hypermetabolic state and ultimately cell death. Clinical and laboratory manifestations include tachycardia, hyperthermia, muscle rigidity, rhabdomyolysis, respiratory and metabolic acidosis, and electrolyte derangements.

Method	TaqMan SNP assay
Breed list	Appaloosa, Paint Horse, Quarab, Quarter Horse, Quarter pony
Heredity	autosomal dominant
Duration	3 - 5 days after arrival of the sample in the lab