Normetanephrine, Metanephrine (from plasma)

LABOKLIN Service ID: 1322


Testing for suspected pheochromocytoma.

Material

EDTA plasma 1 ml (centrifuged immediately, pipetted off)

  • Please pay attention to the note – country-specific! – on the submission form regarding the temperature during storage/transport!

Method

Liquid chromatography-mass spectrometry (LCMS)

Species list

Dog, others on request

Duration

2–6 working days

Remark

  • If the results are up to four times the upper reference range, overlaps with other diseases (especially Cushing's syndrome) and stress-induced catecholamine release are possible. Concentrations within the reference range do not necessarily rule out pheochromocytoma.
  • Normetanephrine is considered the more sensitive parameter in dogs, as it can be used to distinguish more reliably between pheochromocytoma and other diseases.
  • Medications such as phenoxybenzamine, metoclopramide, β-blockers, calcium channel blockers or sympathomimetics can increase catecholamine concentrations.