GLDH (Glutamate Dehydrogenase)

LABOKLIN Service ID: 10


Material

Serum or EDTA plasma or heparin plasma 0.5 ml;
Reptiles: heparin plasma or serum 0.2 ml

Method

Photometry

Duration

Reporting of results on the day the sample is received (Mon–Sat)

Remark

  • The enzyme is liver-specific and located in the mitochondrion. Thus, elevations are indicative of massive destruction of liver cells and necrobiotic processes, especially in the centrilobular area. If concentrations of GLDH are increased, but at the same time ALT concentrations are changed only slightly, it indicates chronic inflammation of the liver.
  • Dog: Single values have no diagnostic significance. Slight elevation of GLDH and stronger elevation of transaminases indicate acute disease of the liver. Opposite enzyme activity indicates chronic processes.
  • Rabbit: GLDH is the most sensitive liver enzyme – an acute parameter (acute hepatopathy with centrolobular damage; strong increase in activity in anorexia, intoxication).