Factor XII deficiency (F12)

LABOKLIN Service ID: 8806

Coagulation factor XII is involved in the intrinsic cascade of blood coagulation. Two different variants have been described in the factor XII gene that trigger FXII deficiency. Homozygous affected cats have a strongly reduced FXII activity, while heterozygous affected cats only show a moderately reduced FXII activity. If both variants are present in heterozygous state, no functional FXII protein will be built. The cat has to be considered as homozygous affected. FXII deficiency manifests as prolonged clotting time in the partial thromboplastin time (PTT) screening test. Affected cats have not experienced abnormal bleeding.

Method	sequencing
Heredity	autosomal recessive
Duration	1 - 2 weeks after arrival of the samples in the lab