Cryptococcus is a yeast and mainly found in bird faeces and contaminated soil and dust. Cryptococci are potential causative agents of systemic infections in humans, domestic and wild animals. Direct transmission from vertebrates to humans has not yet been observed. In dogs, cryptococcosis can manifest itself in different ways, for example as gastrointestinal signs, arthritis, neurological deficits, skin changes and especially respiratory symptoms. As Cryptococcus neoformans infection can lead to serious diseases, early detection is relevant.