LABOKLIN Service ID: 2141
| Diagnosis | - Endocrine-active adrenal neoplasia, adrenal hyperplasia
- Early Cushing’s disease
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| Material | Serum 2 x 0.5 ml |
| Execution | - First blood collection = baseline value
- Dog: Injection of 5 μg ACTH/kg as Cosacthen® i.v./i.m.
- Second blood collection 1 hour post ACTH injection = stimulation value
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| Parameter | (2x cortisol, 2x 17 OH-progesterone) |
| Species list | Dog |
| Duration | 2 - 5 days |
| Assessment | - Corresponds to the basic ACTH Stimulation Test regarding the interpretation of cortisol.
- To clarify steroidal adrenal pathologies, cortisol and 17-OHprogesterone can be determined simultaneously. This is also possible in case of questionable results when determining the cortisol level after ACTH stimulation.
- In dogs with physiological steroid hormone synthesis, the concentration of 17-OH-progesterone increases to up to 180 ng/dl in the ACTH stimulation test.
- Dogs with a possible imbalance in the synthesis, which is found, for example, in case of enzyme defects or adrenal tumours, show an increased baseline concentration and significant hyperstimulation.
- Dogs with pituitary-dependent hyperadrenocorticism also show hyperstimulation. If the cortisol level is also significantly increased after stimulation, it indicates classic hyperadrenocorticism.
- Because of the test properties, patients that are already being treated with Vetoryl® cannot be tested for 17-OH-progesterone.
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