Congenital myasthenic syndrome (CMS)

LABOKLIN Service ID: 8592

The congenital myasthenic syndrome is caused by a mutation located in the COLQ-gene. Symptoms of the disease correlate to human CMS and are described as generalized amyosthenia particularly following stress or agitation. First symptoms appear at three weeks of age. Affected cats often exhibit a “squirrel”-like posture and rest their front paws on elevated objects. Almost all cats with CMS die during their first two years of life. Most of those cats suffocate while feeding.

Method	sequencing
Breed list	Devon Rex, Sphynx
Heredity	autosomal recessive
Duration	1 - 2 weeks after arrival of the sample in the lab