BRAF Comp. (V595E + 2 CNA) (dog)

LABOKLIN Service ID: 518

Indications:

  • It was not possible to get a reliable histological/cytological diagnosis.
  • Screening for transitional cell carcinoma in certain predisposed terrier breeds (e.g. Scottish Terrier, Fox Terrier, Jack Russell Terrier, West Highland White Terrier)
  • Difficult patient

Material

  • urinary sediment (especially early morning urine; fluid + smear)
  • aspiration cytology (smears)
    biopsies (formalin-fixed)

Method

droplet digital PCR (ddPCR) and copy number alteration (CNA)

Species list

dog

Duration

2 - 7 days

Remark

Detection of BRAF variant V595E and detection of copy number alterations (CNAs) 13/19 and 36/19.
Only a positive result is conclusive.
Reasons for negative results:

  • The transitional cell carcinoma is not caused by BRAF mutation or the CNAs 13/19 and 36/19.
  • There were no or too few relevant cells in the sample.
  • It is not a transitional cell carcinoma.

The test for CNAs is not suitable for prostate carcinomas.
The test cannot be used for cats.