BRAF Mutation Test (V595E) (dog)

LABOKLIN Service ID: 8675


Detection of BRAF variant V595E.Indications:

  • It was not possible to get a reliable histological/cytological diagnosis.
  • Screening for urothelial carcinoma (transitional cell carcinoma) in certain predisposed terrier breeds (e.g. Scottish Terrier, Fox Terrier, Jack Russell Terrier, West Highland White Terrier)
  • Difficult patient

    • Material

    If urothelial carcinoma (transitional cell carcinoma) is suspected:

  • Urinary sediment (especially early morning urine; fluid + smear) or
  • Aspiration cytology (smears) or
  • Formalin-fixed, paraffin-embedded tissue (from previous histological examination)

    • If prostate carcinoma is suspected:
  • Smears rich in cells or
  • Formalin-fixed, paraffin-embedded tissue (from previous histological examination)

    • Method

    Droplet digital PCR

    Species list

    Dog

    Duration

    3–5 working days

    Remark

  • Only a positive result is conclusive.
  • Reasons for negative results:
      • - The urothelial (transitional cell)/prostate carcinoma is not caused by BRAF mutation (approx. 30–50% of these carcinomas – depending on the breed).
      - There were no mutated cells present in the sample.
      - It is not a urothelial (transitional cell)/prostate carcinoma.
  • The test cannot be used for cats.