Leukocyte adhesion deficiency type III (LAD3)

LABOKLIN Service ID: 8327

Leucocyte adhesion deficiency (LAD3) is an inherited immuno deficiecy disease. It is cause by a recessive mutation that impairs cell to cell adhesion for leucocytes. Thereby, chemotaxis does not take place and granulocytes are unable to migrate to the site of the infection. The animals are unable to form pus or neutrophilia. Affected dogs develop severe infections early in life, due to a weak immune system. Those infections persist even when high doses of antibiotics are applied.

Method	sequencing
Breed list	German Shepherd Dog
Heredity	autosomal recessive
Duration	1 - 2 weeks after arrival of the sample in the lab