Warburg micro syndrome 1 (WARBM1)

LABOKLIN Service ID: 8347

The Warburg micro syndrome 1 (WARBM1) in Huskies is caused by a recessive SINE insertion in the RAB3GAP1 gene. Symptoms include developmental defects and polyneuropathy. Affected dogs exhibit polyneuropathy with ocular abnormalities and neuronal vacuolation. Additionally, a progressive severe ataxia develops, which leads to euthanasia of the puppies at an age between 8 to 16 month.

Method	sequencing
Breed list	Siberian Husky
Heredity	autosomal recessive
Duration	1-2 weeks after arrival of the sample in the lab