Coat colour variant colourpoint (siam/mink/burma)
LABOKLIN Service ID: 8258
The Tyrosinase (TYR) gene produces an enzyme that is required for melanin production. The wild type allele C is dominant and causes full pigmentation, two mutations in TYR have been associated with temperature-sensitive pigment production that results in colors known as Burmese and Siamese. The wild type phenotype is full color. The Burmese phenotype, which is the mildest form of albinism, is characterized by a normal pigmentation of the extremities and a slight shading of normal body colour. The eyes are yellow-gray or yellow-green. The Siamese phenotype reduces pigment production to the points and the eyes are blue. The wild type (C) allele is dominant to Burmese (cb). Burmese is incompletely dominant to Siamese (cs); Burmese and Siamese heterozygotes (cb/cs) are intermediate in color (mink).These tests identify carriers of Burmese (also called sepia) and Siamese pointed coloration.
| Method | TaqMan SNP assay, if necessary sequencing |
| Breed list | Abyssinian, American Bobtail Longhair, American Bobtail Shorthair, American Curl Longhair, American Curl Shorthair, American Shorthair, American Wirehair, Anatoli, Arabian Mau, Australian Mist, Balinese, Birman (Sacred cat of Burma), Bombay, Brazilian Shorthair, British Longhair, British Shorthair (BSH), Burmese, Burmilla, Ceylon cat, Chartreux, Chausie, Cornish Rex, Crossbred / Mixed Breed, Cymric cat, Devon Rex, Donskoy, Egyptian Mau, European Shorthair, Exotic Shorthair, Foldex, German Longhair, German Rex, Himalayan, Japanese Bobtail Longhair, Japanese Bobtail Shorthair, Javanese, Kanaani, Kartäuser, Korat, Kurilian Bobtail, LaPerm Longhair, LaPerm Shorthair, Maine Coon, Manx cat, Munchkin, Nebelung, Neva Masquerade, Norwegian Forest Cat, Ocicat, Ojos Azules, Oriental Longhair, Oriental Shorthair (OSH), Persian, Peterbald, Pixie-bob Longhair, Pixie-bob Shorthair, Ragdoll, Russian Blue, Savannah, Scottish Fold Longhair, Scottish Fold Shorthair, Selkirk Rex Longhair, Selkirk Rex Shorthair, Serengeti, Seychellois, Siamese, Siberian, Singapura, Snowshoe, Sokoke, Somali, Sphynx, Thai, Tonkinese, Toyger, Turkish Angora, Türkisch Van, Ural Rex, other / unknown |
| Duration | 3 - 5 days after arrival of the sample in the lab (in case of sequencing 1 - 2 weeks) |