Dandy-Walker-like malformation (DWLM)

LABOKLIN Service ID: 8260

Workgroups of Prof. Andrea Fischer from the university of Munich and of Prof. Tosso Leeb from the university of Bern found a causative mutation for cerebellar hypoplasia in dogs for the first time: A mutation in the VLDLR-gene is responsible for the so called Dandy-Walker-like malformation (DWLM) found in Eurasian dogs. DWLM as a disease is caused by a malformation of the cerebellum. Symptoms include various forms of ataxia and commence at the age of 5-6 weeks. Affected dogs exhibit wobbly gait, loss of balance or periodic reoccurring collapses. Epileptic seizures were described in some cases as well.

Method	TaqMan SNP assay
Breed list	Eurasian
Heredity	autosomal recessive
Duration	3 - 5 days after arrival of the sample