LABOKLIN Service ID: 497<\/span><\/p> Differentiated analysis of disorders of blood pressure and electrolyte\r\nregulation: Serum 1ml (centrifuged and separated shortly after coagulation, pipetted off; frozen until arrival at the laboratory \u2013 please contact the laboratory for transport options in advance)<\/p><\/td><\/tr> Renin activity, angiotensin I+II concentration and aldosterone concentration (quantitative)<\/p><\/td><\/tr> Liquid chromatography-mass spectrometry (LCMS)<\/p><\/td><\/tr> Dog, cat<\/p><\/td><\/tr> 3\u20136 working days<\/p><\/td><\/tr> Angiotensin I (Ang I)<\/strong> Note: The sample must arrive frozen at the laboratory. Please contact laboratory for transport options.<\/p><\/td><\/tr><\/table>\n","protected":false},"excerpt":{"rendered":" RAAS StatusLABOKLIN Service ID: 497Renin-angiotensin-aldosterone system statusDiagnosisDifferentiated analysis of disorders of blood pressure and electrolyte regulation:differentiation between primary and secondary hyperaldosteronismcardiac and renal diseasessystemic hypertensionmonitoring of pharmacological RAAS blockades (ACE inhibitors, ARBs (angiotensin receptor blockers), MRAs (mineralocorticoid receptor antagonists))MaterialSerum 1ml (centrifuged and separated shortly after coagulation, pipetted off; frozen until arrival at the laboratory \u2013…<\/p>\n","protected":false},"author":10,"featured_media":0,"parent":1420017,"menu_order":11,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","_seopress_robots_follow":"","_seopress_robots_imageindex":"","_seopress_robots_snippet":"","_seopress_robots_primary_cat":"","_seopress_robots_breadcrumbs":"","_seopress_robots_freeze_modified_date":"","_seopress_robots_custom_modified_date":"","_seopress_robots_canonical":"","_seopress_social_fb_title":"","_seopress_social_fb_desc":"","_seopress_social_fb_img":"","_seopress_social_fb_img_attachment_id":0,"_seopress_social_fb_img_width":0,"_seopress_social_fb_img_height":0,"_seopress_social_twitter_title":"","_seopress_social_twitter_desc":"","_seopress_social_twitter_img":"","_seopress_social_twitter_img_attachment_id":0,"_seopress_social_twitter_img_width":0,"_seopress_social_twitter_img_height":0,"_seopress_redirections_value":"","_seopress_redirections_enabled":"","_seopress_redirections_enabled_regex":"","_seopress_redirections_logged_status":"both","_seopress_redirections_param":"","_seopress_redirections_type":301,"_seopress_analysis_target_kw":"","_seopress_news_disabled":"","_seopress_video_disabled":"","_seopress_video":[],"_seopress_pro_schemas_manual":[],"_seopress_pro_rich_snippets_disable_all":"","_seopress_pro_rich_snippets_disable":[],"_seopress_pro_schemas":[],"footnotes":""},"class_list":["post-1530920","page","type-page","status-publish","hentry","description-off"],"_links":{"self":[{"href":"https:\/\/laboklin.com\/se\/wp-json\/wp\/v2\/pages\/1530920","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/laboklin.com\/se\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/laboklin.com\/se\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/laboklin.com\/se\/wp-json\/wp\/v2\/users\/10"}],"replies":[{"embeddable":true,"href":"https:\/\/laboklin.com\/se\/wp-json\/wp\/v2\/comments?post=1530920"}],"version-history":[{"count":2,"href":"https:\/\/laboklin.com\/se\/wp-json\/wp\/v2\/pages\/1530920\/revisions"}],"predecessor-version":[{"id":1545690,"href":"https:\/\/laboklin.com\/se\/wp-json\/wp\/v2\/pages\/1530920\/revisions\/1545690"}],"up":[{"embeddable":true,"href":"https:\/\/laboklin.com\/se\/wp-json\/wp\/v2\/pages\/1420017"}],"wp:attachment":[{"href":"https:\/\/laboklin.com\/se\/wp-json\/wp\/v2\/media?parent=1530920"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Renin-angiotensin-aldosterone system status<\/p>Diagnosis<\/strong><\/td> Material<\/strong><\/td> Parameter<\/strong><\/td> Method<\/strong><\/td> Species list<\/strong><\/td> Duration<\/strong><\/td> Assessment<\/strong><\/td>
\u2191 Ang I = increased renin release (volume deficiency, Na deficiency, heart failure, medication)
\u2193 Ang I = decreased renin release (hypervolaemia, primary hyperaldosteronism)
Angiotensin II (Ang II)<\/strong>
\u2191 Ang II = increased ACE activity or RAAS activation
\u2193 Ang II = successful ACE blockade, e.g. after administration of enalapril, or low activation of the renin-angiotensin-aldosterone system (e.g. in primary hyperaldosteronism)
Aldosterone<\/strong>
\u2191 Aldosterone while \u2193 Ang II \u2192 Aldosterone escape = autonomous, ACE-independent aldosterone production
\u2191 Aldosterone while \u2191 Ang II \u2192 classic RAAS activation
\u2193 Aldosterone \u2192 suppressed RAAS axis or hypokalaemia
Renin activity (PRA-S)<\/strong> \u2013 indirectly determined via Ang I + Ang II
\u2191 PRA-S = renin release through negative feedback (e.g. after administration of ACE inhibitors, volume deficiency)
\u2193 PRA-S = renin suppression (volume overload, hypertension, high sodium intake, primary hyperaldosteronism)
ACE activity (ACE-S)<\/strong> \u2013 determined by the Ang II\/Ang I ratio
\u2191 ACE-S = high conversion of Ang I \u2192 Ang II \u2192 active RAAS
\u2193 ACE-S = functional inhibition of ACE, e.g. after administration of enalapril, or low Ang II production
AA2 ratio (aldosterone\/Ang II)<\/strong> \u2013 the most important marker for functional examination
low AA2: aldosterone proportional to Ang II \u2192 classic axis intact
high AA2: aldosterone disproportionately high despite low Ang II \u2192 Ang II-independent aldosterone production (primary hyperaldosteronism)<\/p><\/td><\/tr>Remark<\/strong><\/td>