{"id":1428007,"date":"2022-09-06T10:54:57","date_gmt":"2022-09-06T08:54:57","guid":{"rendered":"https:\/\/staging-wp-int.laboklin.com\/products\/haematology-clin-chemistry-endocrinology\/function-tests-calculation-formulas\/dexamethasone-suppression-test\/"},"modified":"2025-07-15T13:42:04","modified_gmt":"2025-07-15T11:42:04","slug":"dexamethasone-suppression-test-low-dose","status":"publish","type":"page","link":"https:\/\/laboklin.com\/no\/products\/haematology-clin-chemistry-endocrinology\/function-tests-calculation-formulas\/dexamethasone-suppression-test-low-dose\/","title":{"rendered":"Dexamethasone Suppression Test (low dose)"},"content":{"rendered":"<h3 class=\"csc-firstHeader\">Dexamethasone Suppression Test (low dose) <\/h3><p><span>LABOKLIN Service ID: 142<\/span><\/p><p class=\"bodytext\"><br><\/p><table class=\"tx-laboklinleistung-table contenttable contenttable-2\" style=\"margin-top: 35px;\"><tr><td class=\"td-0\"><strong>Diagnosis<\/strong><\/td><td class=\"td-1\"><p class=\"bodytext\">Testing for Cushing\u2019s syndrome \/ Suspected PPID (Cushing\u2019s disease)<\/p><\/td><\/tr><tr><td class=\"td-0\"><strong>Material<\/strong><\/td><td class=\"td-1\"><p class=\"bodytext\">Serum 2x 0.5 ml or 3x 0.5 ml (see also remark)<\/p><\/td><\/tr><tr><td class=\"td-0\"><strong>Execution<\/strong><\/td><td class=\"td-1\"><p><strong>Dog\/cat\/Guinea pig<\/strong><br><ul><li>First blood collection = baseline value<\/li><li>Administration of dexamethasone:<br><strong>Dog<\/strong> i.v. (or i.m.): 0.01 mg\/kg bdw<br><strong>Cat<\/strong> i.v. (or i.m.): 0.1 mg\/kg bdw<br><strong>Guinea pig<\/strong> i.m. or i.v.: 0.1 mg\/kg bdw<\/li><li>Blood collection 4 hours post injection = 1<sup>st<\/sup> suppression value<\/li><li>Blood collection 8 hours post injection = 2<sup>nd<\/sup> suppression value <\/li><\/ul><br><strong>Horse (Overnight Dexamethasone Suppression Test)<\/strong><ul><li>First blood collection = baseline value (blood sampling at around 4\u20136 pm)<\/li><li>Injection of 2 mg\/50 kg bdw of dexamethasone i.v.<\/li><li>Blood sampling approx. 15 hours after administration of dexamethasone (at around 8\u201310 am) = 1<sup>st<\/sup> suppression value \u2013 may be omitted<\/li><li>2<sup>nd<\/sup> suppression value after approx. 18\u201320 hours (at around 10 am\u20131 pm) \u2013 the decisive value<\/li><li>Because of the circadian rhythm, the indicated times of the day should be observed.<\/li><\/ul><\/p><\/td><\/tr><tr><td class=\"td-0\"><strong>Parameter<\/strong><\/td><td class=\"td-1\"><p class=\"bodytext\">Cortisol<\/p><\/td><\/tr><tr><td class=\"td-0\"><strong>Method<\/strong><\/td><td class=\"td-1\"><p class=\"bodytext\">Chemiluminescence assay (CLIA)<\/p><\/td><\/tr><tr><td class=\"td-0\"><strong>Species list<\/strong><\/td><td class=\"td-1\"><p class=\"bodytext\">Dog, cat, guinea pig, horse<\/p><\/td><\/tr><tr><td class=\"td-0\"><strong>Duration<\/strong><\/td><td class=\"td-1\"><p class=\"bodytext\">Reporting of results on the day the sample is received (Mon\u2013Sat)<\/p><\/td><\/tr><tr><td class=\"td-0\"><strong>Assessment<\/strong><\/td><td class=\"td-1\"><p><strong>Dog\/cat:<\/strong><br><ul><li>Both suppression values < 10 ng\/ml: Cushing\u2019s syndrome unlikely<\/li><li>One suppression value < 10 ng\/ml: Cushing\u2019s syndrome questionable<\/li><li>Insufficient suppression: A lack of suppression may indicate the presence of Cushing\u2019s syndrome if the clinical picture is appropriate. Insufficient suppression is also seen in other diseases.<\/li><\/ul><br><strong>Guinea pig:<\/strong><ul><li>Evaluation: adequate suppression and interpretation as in dogs, reference values not available<\/li><li>For testing using saliva, see the Saliva Cortisol Suppression Test<\/li><\/ul><br><strong>Horse:<\/strong><ul><li>PPID: one or both suppression values > 10 ng\/ml<\/li> <li>Cave: In late summer\/autumn, healthy horses, too, possibly suppress insufficiently.<\/li><\/ul><\/p><\/td><\/tr><tr><td class=\"td-0\"><strong>Remark<\/strong><\/td><td class=\"td-1\"><p class=\"bodytext\"><ul><li> The test with examination of 2 suppression values (3 serum samples) can be found on the online submission forms and in the practice programmes under service ID 1142.<\/li><li>Can be performed as an alternative to the TRH Stimulation Test.<\/li><li>PPID (formerly known as Cushing\u2019s disease) in horses is caused by \u201cpituitary adenoma\u201d (hyperplasia of the pars intermedia). The hyperplastic cells have no cortisol receptors, that is why in PPID, the exogenous administration of dexamethasone does not suppress the endogenous secretion of corticoids as it does in healthy horses.<\/li><\/ul><\/p><\/td><\/tr><\/table>\n","protected":false},"excerpt":{"rendered":"<p>Dexamethasone Suppression Test (low dose) LABOKLIN Service ID: 142DiagnosisTesting for Cushing\u2019s syndrome \/ Suspected PPID (Cushing\u2019s disease)MaterialSerum 2x 0.5 ml or 3x 0.5 ml (see also remark)ExecutionDog\/cat\/Guinea pigFirst blood collection = baseline valueAdministration of dexamethasone:Dog i.v. (or i.m.): 0.01 mg\/kg bdwCat i.v. (or i.m.): 0.1 mg\/kg bdwGuinea pig i.m. or i.v.: 0.1 mg\/kg bdwBlood collection&hellip;<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":1383130,"menu_order":11,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","_seopress_robots_follow":"","_seopress_robots_imageindex":"","_seopress_robots_snippet":"","_seopress_robots_primary_cat":"","_seopress_robots_breadcrumbs":"","_seopress_robots_freeze_modified_date":"","_seopress_robots_custom_modified_date":"","_seopress_robots_canonical":"","_seopress_social_fb_title":"","_seopress_social_fb_desc":"","_seopress_social_fb_img":"","_seopress_social_fb_img_attachment_id":0,"_seopress_social_fb_img_width":0,"_seopress_social_fb_img_height":0,"_seopress_social_twitter_title":"","_seopress_social_twitter_desc":"","_seopress_social_twitter_img":"","_seopress_social_twitter_img_attachment_id":0,"_seopress_social_twitter_img_width":0,"_seopress_social_twitter_img_height":0,"_seopress_redirections_value":"","_seopress_redirections_enabled":"","_seopress_redirections_enabled_regex":"","_seopress_redirections_logged_status":"both","_seopress_redirections_param":"","_seopress_redirections_type":301,"_seopress_analysis_target_kw":"","_seopress_news_disabled":"","_seopress_video_disabled":"","_seopress_video":[],"_seopress_pro_schemas_manual":[],"_seopress_pro_rich_snippets_disable_all":"","_seopress_pro_rich_snippets_disable":[],"_seopress_pro_schemas":[],"footnotes":""},"class_list":["post-1428007","page","type-page","status-publish","hentry","description-off"],"_links":{"self":[{"href":"https:\/\/laboklin.com\/no\/wp-json\/wp\/v2\/pages\/1428007","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/laboklin.com\/no\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/laboklin.com\/no\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/laboklin.com\/no\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/laboklin.com\/no\/wp-json\/wp\/v2\/comments?post=1428007"}],"version-history":[{"count":1,"href":"https:\/\/laboklin.com\/no\/wp-json\/wp\/v2\/pages\/1428007\/revisions"}],"predecessor-version":[{"id":1524247,"href":"https:\/\/laboklin.com\/no\/wp-json\/wp\/v2\/pages\/1428007\/revisions\/1524247"}],"up":[{"embeddable":true,"href":"https:\/\/laboklin.com\/no\/wp-json\/wp\/v2\/pages\/1383130"}],"wp:attachment":[{"href":"https:\/\/laboklin.com\/no\/wp-json\/wp\/v2\/media?parent=1428007"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}