Neuroaxonal dystrophy (NAD)

LABOKLIN Service ID: 8308

The neuroaxonal dystrophy (NAD) is characterised by a histologically distinct neurodegenerative pathology of the central and/or peripheral nervous system. As with most neurological disorders, symptoms may vary and the disease itself is therefore diagnostically nonspecific. The onset of the disease takes place in early development.
In dogs, late-gestational fetal akinesia, multiple joint fixation and pulmonary hypoplasie are found in animals which are homozygous for the mutated allele. Those puppies die at birth due to respiratory failure and exhibit swollen axons and spheroids throughout the nervous system.

Method

TaqMan SNP assay, if necessary sequencing

Breed list

Lagotto Romagnolo, Miniature American Shepherd, Papillon, Rottweiler, Spanish Water Dog

Heredity

autosomal recessive

Duration

3-5 days after arrival of the sample in the lab (in case of sequencing 1-2 weeks)