{"id":1515791,"date":"2024-08-22T14:03:08","date_gmt":"2024-08-22T12:03:08","guid":{"rendered":"https:\/\/laboklin.com\/products\/pathology\/tumour-genetic-tests\/molecular-genetic-tumour-panel-dog\/"},"modified":"2026-02-27T09:09:48","modified_gmt":"2026-02-27T08:09:48","slug":"molecular-genetic-tumour-panel-dog","status":"publish","type":"page","link":"https:\/\/laboklin.com\/fr\/prestations\/pathologie\/tests-tumorigenetiques\/molecular-genetic-tumour-panel-dog\/","title":{"rendered":"Molecular Genetic Tumour Panel (dog)"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column][vc_column_text css=\u00a0\u00bb\u00a0\u00bb]<h3 class=\"csc-firstHeader\">Molecular Genetic Tumour Panel (dog)<\/h3><p><span>LABOKLIN Service ID: 1258<\/span><\/p><p class=\"bodytext\">For a more precise characterization of malignant tumours in dogs, a comprehensive analysis of the tumourgenome can be performed in selected cases.<br><strong>Therapeutic:<\/strong><br><ul><li>Lack of known or conventional therapy concepts<\/li><li>(therapy-resistant) recurrence<\/li><\/ul>Genomics-based targeted treatment can potentially provide a new treatment option (reglementation for off-label use of drugs).<br><strong>Diagnostic:<\/strong><br><ul><li>A definitive cytological or (immuno)histological diagnosis was not possible<\/li><\/ul>The molecular genetic signature can help to further narrow down the diagnosis (e.g. histiocytic neoplasia versus inflammation) and may also provide a treatment option.<\/p><table class=\"tx-laboklinleistung-table contenttable contenttable-2\" style=\"margin-top: 35px;\"><tr><td class=\"td-0\"><strong>Material<\/strong><\/td><td class=\"td-1\"><p class=\"bodytext\"><ul><li>15 smears rich in tumour cells (not covered)<\/li><li>Biopsies > 0.5 cm (formalin-fixed)<\/li><li>Tumour resectates (formalin-fixed)<\/li><li>Paraffin blocks with sufficient tumour material (paraffin rolls are NOT suitable)<\/li>NOT possible from decalcified tissue<\/li><\/ul><\/p><\/td><\/tr><tr><td class=\"td-0\"><strong>Parameter<\/strong><\/td><td class=\"td-1\"><p class=\"bodytext\">Examination of approximately 20,000 genes for mutations<\/p><\/td><\/tr><tr><td class=\"td-0\"><strong>Method<\/strong><\/td><td class=\"td-1\"><p class=\"bodytext\">Next Generation Sequencing (NGS) (VetOmics, Canine CGP\u00ae)<\/p><\/td><\/tr><tr><td class=\"td-0\"><strong>Species list<\/strong><\/td><td class=\"td-1\"><p class=\"bodytext\">dog<\/p><\/td><\/tr><tr><td class=\"td-0\"><strong>Duration<\/strong><\/td><td class=\"td-1\"><p class=\"bodytext\">approx. 3 weeks <\/p><\/td><\/tr><tr><td class=\"td-0\"><strong>Remark<\/strong><\/td><td class=\"td-1\"><p class=\"bodytext\"><strong>result<\/strong><br><ul><li>Summary of the molecular genetic results<\/li><li>Explanations and literature references on the biomarkers found<\/li><li>Specification of the tumour mutation burden to predict response to checkpoint inhibitors (e.g. PD-1, PDL-1 inhibitors, APAVAC)<\/li><li> Suitable drugs for individualised tumour treatment are suggested, along with dosages and information on the level of evidence.<\/li><li>If necessary, further advice on the treatment options found by e-mail directly from the oncologists in the USA<\/li><\/ul><strong>Limitations<\/strong><br><ul><li>A sufficient number of tumour cells and DNA quality are required<\/li><li>It is not always possible to isolate DNA in sufficient quantity and quality<\/li><li>Mutations that open up a treatment option are not found in every case<\/li><li>Availability and cost of medication may vary from country to country<\/li><li>The medications may not be authorised for dogs in all countries<\/li><li>The efficacy of these medications in dogs is supported by varying degrees of evidence<\/li><li>The data on efficacy and side effects in the respective canine tumours is often incomplete<\/li><\/ul>The decision and responsibility for the use of the medication listed in the report lies with the veterinarian in charge!<br>It is recommended that a specialised oncologist should be consulted in such cases.<\/p><\/td><\/tr><\/table><div class=\"gap\" style=\"line-height: 20px; height: 20px;\"><\/div>\n<p>[\/vc_column_text][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][vc_column_text css=\u00a0\u00bb\u00a0\u00bb] [\/vc_column_text][\/vc_column][\/vc_row]<\/p>\n","protected":false},"author":10,"featured_media":0,"parent":1383313,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_seopress_robots_primary_cat":"","_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","footnotes":""},"class_list":["post-1515791","page","type-page","status-publish","hentry","description-off"],"_links":{"self":[{"href":"https:\/\/laboklin.com\/fr\/wp-json\/wp\/v2\/pages\/1515791","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/laboklin.com\/fr\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/laboklin.com\/fr\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/laboklin.com\/fr\/wp-json\/wp\/v2\/users\/10"}],"replies":[{"embeddable":true,"href":"https:\/\/laboklin.com\/fr\/wp-json\/wp\/v2\/comments?post=1515791"}],"version-history":[{"count":2,"href":"https:\/\/laboklin.com\/fr\/wp-json\/wp\/v2\/pages\/1515791\/revisions"}],"predecessor-version":[{"id":1542648,"href":"https:\/\/laboklin.com\/fr\/wp-json\/wp\/v2\/pages\/1515791\/revisions\/1542648"}],"up":[{"embeddable":true,"href":"https:\/\/laboklin.com\/fr\/wp-json\/wp\/v2\/pages\/1383313"}],"wp:attachment":[{"href":"https:\/\/laboklin.com\/fr\/wp-json\/wp\/v2\/media?parent=1515791"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}