{"id":1471461,"date":"2023-11-21T16:46:32","date_gmt":"2023-11-21T15:46:32","guid":{"rendered":"https:\/\/laboklin.com\/?page_id=1471461"},"modified":"2023-11-21T16:46:45","modified_gmt":"2023-11-21T15:46:45","slug":"cerebellar-hypoplasia-ch","status":"publish","type":"page","link":"https:\/\/laboklin.com\/fr\/prestations\/genetique\/maladies-hereditaires\/dog\/cerebellar-hypoplasia-ch\/","title":{"rendered":"Cerebellar hypoplasia (CH)"},"content":{"rendered":"

Cerebellar hypoplasia (CH)<\/h3>

LABOKLIN Service ID: 8868<\/span><\/p>

A mutation in the RELN gene has been identified in White Swiss Shepherd dogs that causes cerebellar hypoplasia (CH), a condition where the cerebellum does not develop fully. Affected puppies were born clinically normal, but then they failed to gain weight and developed progressive ataxia at around 2 weeks of age. Affected puppies showed difficulties in standing, walking in a straight line and latching onto the teat, even though the suckling reflex is good. Due to worsening of the symptoms, the puppies had to be euthanized at the age of 4 weeks. Post-mortem examination revealed abnormalities in the brains with severe CH with lissencephaly (abnormal structure of cortical surface folds) and moderate internal hydrocephalus with enlarged lateral vertricles and fourth ventricle.<\/p>
Method<\/strong><\/td>

sequencing<\/p><\/td><\/tr>

Breed list<\/strong><\/td>

White Swiss Shepherd Dog<\/p><\/td><\/tr>

Heredity<\/strong><\/td>

autosomal recessive<\/p><\/td><\/tr>

Duration<\/strong><\/td>

1 - 2 weeks after arrival of the sample in the lab<\/p><\/td><\/tr><\/table>\n","protected":false},"excerpt":{"rendered":"

Cerebellar hypoplasia (CH)LABOKLIN Service ID: 8868A mutation in the RELN gene has been identified in White Swiss Shepherd dogs that causes cerebellar hypoplasia (CH), a condition where the cerebellum does not develop fully. Affected puppies were born clinically normal, but then they failed to gain weight and developed progressive ataxia at around 2 weeks of…<\/p>\n","protected":false},"author":10,"featured_media":0,"parent":1419953,"menu_order":120,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_seopress_robots_primary_cat":"","_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","footnotes":""},"class_list":["post-1471461","page","type-page","status-publish","hentry","description-off"],"_links":{"self":[{"href":"https:\/\/laboklin.com\/fr\/wp-json\/wp\/v2\/pages\/1471461","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/laboklin.com\/fr\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/laboklin.com\/fr\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/laboklin.com\/fr\/wp-json\/wp\/v2\/users\/10"}],"replies":[{"embeddable":true,"href":"https:\/\/laboklin.com\/fr\/wp-json\/wp\/v2\/comments?post=1471461"}],"version-history":[{"count":1,"href":"https:\/\/laboklin.com\/fr\/wp-json\/wp\/v2\/pages\/1471461\/revisions"}],"predecessor-version":[{"id":1471469,"href":"https:\/\/laboklin.com\/fr\/wp-json\/wp\/v2\/pages\/1471461\/revisions\/1471469"}],"up":[{"embeddable":true,"href":"https:\/\/laboklin.com\/fr\/wp-json\/wp\/v2\/pages\/1419953"}],"wp:attachment":[{"href":"https:\/\/laboklin.com\/fr\/wp-json\/wp\/v2\/media?parent=1471461"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}