{"id":1418417,"date":"2022-08-18T13:57:31","date_gmt":"2022-08-18T11:57:31","guid":{"rendered":"https:\/\/staging-wp-int.laboklin.com\/dwarfism-acan-chondrodysplasia\/"},"modified":"2022-08-18T13:57:31","modified_gmt":"2022-08-18T11:57:31","slug":"dwarfism-acan-chondrodysplasia","status":"publish","type":"page","link":"https:\/\/laboklin.com\/fr\/prestations\/genetique\/maladies-hereditaires\/horse\/dwarfism-acan-chondrodysplasia\/","title":{"rendered":"Dwarfism (ACAN, Chondrodysplasia)"},"content":{"rendered":"

Dwarfism (ACAN, Chondrodysplasia)<\/h3>

LABOKLIN Service ID: 8548<\/span><\/p>

Dwarfism is most common in Shetland ponies and miniature horses. Phenotypical features of this hereditary disease are breathing problems due to a cleft palate, deformed mouths, shortened limbs and bowed forelegs, disproportionately large cranium and shortened neck, protruding eyes, abdominal hernia and a shortened rib cage. As a result, affected animals are often not viable or have to be euthanized due to the poor quality of life. A mutation in the ACAN gene is responsible for this form of dwarfism. 4 different mutations, which cause the autosomal-recessive disease, are known so far. These are named D1, D2, D3, and D4 and are also pathogenic as compound heterozygous genes. Compound heterozygous variants together with D1 (except N\/D1) are more deleterious and often lead to death. A combination with the D2 variant is considered as the mildest form of dwarfism. <\/p>
Method<\/strong><\/td>

sequencing<\/p><\/td><\/tr>

Breed list<\/strong><\/td>

American Miniature Horse, Shetland pony<\/p><\/td><\/tr>

Heredity<\/strong><\/td>

see test information<\/p><\/td><\/tr>

Duration<\/strong><\/td>

1 - 2 weeks after arrival of the sample in the lab<\/p><\/td><\/tr><\/table>\n","protected":false},"excerpt":{"rendered":"

Dwarfism (ACAN, Chondrodysplasia)LABOKLIN Service ID: 8548Dwarfism is most common in Shetland ponies and miniature horses. Phenotypical features of this hereditary disease are breathing problems due to a cleft palate, deformed mouths, shortened limbs and bowed forelegs, disproportionately large cranium and shortened neck, protruding eyes, abdominal hernia and a shortened rib cage. As a result, affected…<\/p>\n","protected":false},"author":10,"featured_media":0,"parent":1423969,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_seopress_robots_primary_cat":"","_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","footnotes":""},"class_list":["post-1418417","page","type-page","status-publish","hentry","description-off"],"_links":{"self":[{"href":"https:\/\/laboklin.com\/fr\/wp-json\/wp\/v2\/pages\/1418417","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/laboklin.com\/fr\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/laboklin.com\/fr\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/laboklin.com\/fr\/wp-json\/wp\/v2\/users\/10"}],"replies":[{"embeddable":true,"href":"https:\/\/laboklin.com\/fr\/wp-json\/wp\/v2\/comments?post=1418417"}],"version-history":[{"count":0,"href":"https:\/\/laboklin.com\/fr\/wp-json\/wp\/v2\/pages\/1418417\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/laboklin.com\/fr\/wp-json\/wp\/v2\/pages\/1423969"}],"wp:attachment":[{"href":"https:\/\/laboklin.com\/fr\/wp-json\/wp\/v2\/media?parent=1418417"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}