{"id":1446421,"date":"2022-09-06T10:55:10","date_gmt":"2022-09-06T08:55:10","guid":{"rendered":"https:\/\/staging-wp-int.laboklin.com\/products\/genetics\/hereditary-diseases\/dog\/spondylocostal-dysostosis-comma-defect\/"},"modified":"2022-09-06T10:55:10","modified_gmt":"2022-09-06T08:55:10","slug":"spondylocostal-dysostosis-comma-defect","status":"publish","type":"page","link":"https:\/\/laboklin.com\/fi\/products\/genetics\/hereditary-diseases\/dog\/spondylocostal-dysostosis-comma-defect\/","title":{"rendered":"Spondylocostal dysostosis (Comma defect)"},"content":{"rendered":"<h3 class=\"csc-firstHeader\">Spondylocostal dysostosis (Comma defect)<\/h3><p><span>LABOKLIN Service ID: 8335<\/span><\/p><p class=\"bodytext\">The spondylocostal dysostosis (comma defect) is a hereditary disease, which is characterized mainly by segmentation of the spine and ribs. The disease is caused by a deletion in the HES7-gene. In addition to the spine and rib defects, newborns exhibit a dispropotional dwarfism. They also have a prominent forehead, an expansive occipital and malformations of the extremities. The malformation of the ribcage lowers chest-volume, which leads to decreased respiratory function. Newborn puppies often die due to suffocation.<\/p><table class=\"tx-laboklinleistung-table contenttable contenttable-2\" style=\"margin-top: 35px;\"><tr><td class=\"td-0\"><strong>Method<\/strong><\/td><td class=\"td-1\"><p class=\"bodytext\">TaqMan SNP assay, if necessary sequencing<\/p><\/td><\/tr><tr><td class=\"td-0\"><strong>Breed list<\/strong><\/td><td class=\"td-1\"><p class=\"bodytext\">Miniature Schnauzer<\/p><\/td><\/tr><tr><td class=\"td-0\"><strong>Heredity<\/strong><\/td><td class=\"td-1\"><p class=\"bodytext\">autosomal recessive<\/p><\/td><\/tr><tr><td class=\"td-0\"><strong>Duration<\/strong><\/td><td class=\"td-1\"><p class=\"bodytext\">3 - 5 days after arrival of the sample in the lab (in case of sequencing 1 - 2 weeks)<\/p><\/td><\/tr><\/table>\n","protected":false},"excerpt":{"rendered":"<p>Spondylocostal dysostosis (Comma defect)LABOKLIN Service ID: 8335The spondylocostal dysostosis (comma defect) is a hereditary disease, which is characterized mainly by segmentation of the spine and ribs. The disease is caused by a deletion in the HES7-gene. In addition to the spine and rib defects, newborns exhibit a dispropotional dwarfism. They also have a prominent forehead,&hellip;<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":1443666,"menu_order":93,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_seopress_robots_primary_cat":"","_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","footnotes":""},"class_list":["post-1446421","page","type-page","status-publish","hentry","description-off"],"_links":{"self":[{"href":"https:\/\/laboklin.com\/fi\/wp-json\/wp\/v2\/pages\/1446421","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/laboklin.com\/fi\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/laboklin.com\/fi\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/laboklin.com\/fi\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/laboklin.com\/fi\/wp-json\/wp\/v2\/comments?post=1446421"}],"version-history":[{"count":0,"href":"https:\/\/laboklin.com\/fi\/wp-json\/wp\/v2\/pages\/1446421\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/laboklin.com\/fi\/wp-json\/wp\/v2\/pages\/1443666"}],"wp:attachment":[{"href":"https:\/\/laboklin.com\/fi\/wp-json\/wp\/v2\/media?parent=1446421"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}