{"id":1310024,"date":"2021-08-20T10:21:05","date_gmt":"2021-08-20T08:21:05","guid":{"rendered":"https:\/\/staging.laboklin.com\/int\/en\/?p=1310024"},"modified":"2025-07-29T13:27:06","modified_gmt":"2025-07-29T11:27:06","slug":"multimodal-treatment-of-atopic-dermatitis","status":"publish","type":"post","link":"https:\/\/laboklin.com\/en\/multimodal-treatment-of-atopic-dermatitis\/","title":{"rendered":"Multimodal treatment of atopic Dermatitis"},"content":{"rendered":"

[vc_row][vc_column width=”2\/3″][vc_column_text]Atopic dermatitis (AD) is an IgE-mediated allergic skin disease to environmental allergens. Several factors play a role in its development, primarily the alteration of the immune response, the alteration of the skin barrier (genetic factors) and the environment.
\nThe clinical presentation of AD is pruritus and its associated lesions. Its genetic condition determines its chronicity and the need for life long treatment.<\/p>\n

Previous considerations to atopic dermatitis treatment<\/strong><\/p>\n

    \n
  1. Diagnosis of the disease<\/strong> – ruling out other pruritic conditions, including food allergy.<\/li>\n
  2. Year round flea control program<\/strong> – the bite of fleas can trigger an allergic dermatitis (Flea allergic dermatitis – FAD) and can complicate atopic disease.<\/li>\n
  3. It is a chronic disease<\/strong> that needs life long treatment of the animal<\/strong> on an annual or seasonal basis, depending on presentation.<\/li>\n<\/ol>\n

    A frequent mistake is to stop the treatment once the animal is free of clinical signs, which leads to reactivation of the inflammatory process. Once inflammation exceeds the itching threshold, the animal begins to scratch and the clinical signs return.<\/p>\n

    Reactive and proactive therapy<\/h2>\n

    “Reactive therapy”<\/strong> represents the treatment of active disease aimed at controlling pruritus and lesions. It is a rescue treatment based on systemic anti-inflammatory\/antipruritic drugs with rapid action and high efficacy, together with frequent topical therapy.<\/p>\n

    Once the clinical picture is controlled and stable for a few weeks, the so-called “proactive therapy”<\/strong>, aimed at avoiding the reactivation of the inflammatory process, would be established. During this treatment phase, the goal is to keep the animal free of clinical signs using the minimum effective dose. In proactive therapy, antiinflammatory\/antipruritic treatment, topical treatment and allergen-specific immunotherapy (ASIT) can be used.<\/p>\n

    Multimodal tailored treatment<\/h2>\n

    Treatment should be multimodal and include:<\/p>\n

      \n
    1. Strict annual flea control program<\/li>\n
    2. Treatment of pruritus with anti-inflammatory\/ antipruritic drugs (systemic and topical)<\/li>\n
    3. Restructuring and hydration of the skin: nutrition and topical treatment<\/li>\n
    4. Control of secondary infections<\/li>\n
    5. Allergen-specific immunotherapy (ASIT) or “allergy vaccine”<\/li>\n<\/ol>\n

      1. Flea control<\/h2>\n

      Atopic animals are more prone to developing other allergies. Contact with fleas can trigger the allergic process. It is crucial to carry out effective preventive treatment on an annual basis.<\/p>\n

      2. Anti-inflammatory\/antipruritic treatment<\/h2>\n

      Control of inflammation and pruritus is essential to keep the atopic animal free from the clinical signs of the disease. Drugs with proven efficacy in the treatment of atopic dermatitis are:[\/vc_column_text][\/vc_column][vc_column width=”1\/3″][vc_column_text]<\/p>\n\n\t\t\t