{"id":660013,"date":"2022-09-06T10:54:57","date_gmt":"2022-09-06T08:54:57","guid":{"rendered":"https:\/\/staging.laboklin.com\/int\/cortisol-creatinine-ratio"},"modified":"2026-08-14T11:11:37","modified_gmt":"2026-08-14T09:11:37","slug":"cortisol-creatinine-ratio","status":"publish","type":"page","link":"https:\/\/laboklin.com\/en\/products\/haematology-clin-chemistry-endocrinology\/function-tests-calculation-formulas\/cortisol-creatinine-ratio\/","title":{"rendered":"Cortisol\/Creatinine Ratio from urine (UCCR)"},"content":{"rendered":"

Urine Cortisol\/Creatinine Ratio (UCCR)<\/h3>

LABOKLIN Service ID: 183<\/span><\/p>


<\/p>
Diagnosis<\/strong><\/td>

Clarification of Cushing\u2019s disease including differentiation between adrenal and pituitary forms<\/p><\/td><\/tr>

Material<\/strong><\/td>

Morning urine 1 ml<\/p><\/td><\/tr>

Execution<\/strong><\/td>

  • Collection of morning urine day 1 = sample 1<\/li>
  • Collection of morning urine day 2 = sample 2 <\/li>
  • Administration of dexamethasone on day 2: orally 3 x 0.1 mg\/kg bdw throughout the day<\/li>
  • Collection of morning urine day 3 = sample 3 <\/li><\/p><\/td><\/tr>
Parameter<\/strong><\/td>

Cortisol, creatinine<\/p><\/td><\/tr>

Method<\/strong><\/td>

Cortisol: Chemiluminescence assay (CLIA);
Kreatinine: photometry<\/p><\/td><\/tr>

Species list<\/strong><\/td>

Dog<\/p><\/td><\/tr>

Duration<\/strong><\/td>

Reporting of results on the day the sample is received (Mon\u2013Fri)<\/p><\/td><\/tr>

Assessment<\/strong><\/td>

  • Interpretation of the ratio of day 1 and day 2:
    The ratios from the samples taken on days 1 and 2 are used to evaluate the probability of Cushing\u2019s syndrome.<\/li>
  • The sensitivity of the UCCR test is increased by performing repeated measurements. Positive or divergent findings should be verified using a low-dose dexamethasone suppression test. Negative findings indicate that Cushing\u2019s syndrome is unlikely. However, if there is strong clinical suspicion, it is recommended to perform a low-dose dexamethasone suppression test.<\/>
  • Interpretation of the ratio of day 3:
    (An increased ratio on day 1 and day 2 is a prerequisite) > 50% of the average value of the first two samples indicate a cortisol-producing adrenocortical tumour. The presence of nonsuppressible pituitary Cushing\u2019s disease is possible. < 50% of the average value of the first two samples indicate a pituitary-dependent Cushing\u2019s disease or another disease which causes increased cortisol secretion (e.g. diabetes, stress, gastrointestinal diseases, diseases with protein loss).<\/li><\/ul><\/p><\/td><\/tr><\/table>\n","protected":false},"excerpt":{"rendered":"

    Urine Cortisol\/Creatinine Ratio (UCCR)LABOKLIN Service ID: 183DiagnosisClarification of Cushing\u2019s disease including differentiation between adrenal and pituitary formsMaterialMorning urine 1 mlExecution Collection of morning urine day 1 = sample 1 Collection of morning urine day 2 = sample 2 Administration of dexamethasone on day 2: orally 3 x 0.1 mg\/kg bdw throughout the day Collection of…<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":660000,"menu_order":12,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-660013","page","type-page","status-publish","hentry","description-off"],"_links":{"self":[{"href":"https:\/\/laboklin.com\/en\/wp-json\/wp\/v2\/pages\/660013","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/laboklin.com\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/laboklin.com\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/laboklin.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/laboklin.com\/en\/wp-json\/wp\/v2\/comments?post=660013"}],"version-history":[{"count":2,"href":"https:\/\/laboklin.com\/en\/wp-json\/wp\/v2\/pages\/660013\/revisions"}],"predecessor-version":[{"id":1545662,"href":"https:\/\/laboklin.com\/en\/wp-json\/wp\/v2\/pages\/660013\/revisions\/1545662"}],"up":[{"embeddable":true,"href":"https:\/\/laboklin.com\/en\/wp-json\/wp\/v2\/pages\/660000"}],"wp:attachment":[{"href":"https:\/\/laboklin.com\/en\/wp-json\/wp\/v2\/media?parent=660013"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}