{"id":660012,"date":"2022-09-06T10:54:57","date_gmt":"2022-09-06T08:54:57","guid":{"rendered":"https:\/\/staging.laboklin.com\/int\/dexamethasone-suppression-test"},"modified":"2025-07-15T13:42:00","modified_gmt":"2025-07-15T11:42:00","slug":"dexamethasone-suppression-test-low-dose","status":"publish","type":"page","link":"https:\/\/laboklin.com\/en\/products\/haematology-clin-chemistry-endocrinology\/function-tests-calculation-formulas\/dexamethasone-suppression-test-low-dose\/","title":{"rendered":"Dexamethasone Suppression Test (low dose)"},"content":{"rendered":"

Dexamethasone Suppression Test (low dose) <\/h3>

LABOKLIN Service ID: 142<\/span><\/p>
Diagnosis<\/strong><\/td>

Screening test to confirm the diagnosis of Cushing\u2019s disease\/PPID (Horse)<\/p><\/td><\/tr>

Material<\/strong><\/td>

Serum 2 x 0.5 ml or 3 x 0.5 ml<\/p><\/td><\/tr>

Execution<\/strong><\/td>

dog\/cat\/guinea pig<\/strong>

  • First blood collection = baseline value<\/li>
  • Injection of dexamethasone
    i.v. (or i.m.) dog: 0.01 mg\/kg
    i.m. or. i.v. guinea pig: 0.1 mg\/kg
    i.v. (or i.m.) cat: 0.1 mg\/kg <\/li>
  • Blood collection 4 hours post injection = 1st suppression value <\/li>
  • Blood collection 8 hours post injection = 2nd suppression value <\/li><\/ul>
    horse (Overnight Dexamethasone Suppression Test)<\/strong>
    • First blood collection = baseline value (blood sampling at around 4 \u2013 6 pm)<\/li>
    • Injection of 2 mg\/50 kg bdw of dexamethasone i.v.<\/li>
    • Blood sampling approx. 15 hours after administration of dexamethasone (at around 8 \u2013 10 am) = 1st suppression value \u2013 may be omitted<\/li>
    • 2nd suppression value after approx. 18 \u2013 20 hours (at around 10 am \u2013 1 pm) \u2013 obligatory<\/li>
    • Because of the circadian rhythm, the indicated times of the day should be observed.<\/li><\/ul><\/p><\/td><\/tr>
Method<\/strong><\/td>

CLIA<\/p><\/td><\/tr>

Species list<\/strong><\/td>

dog, cat, guinea pig, horse<\/p><\/td><\/tr>

Assessment<\/strong><\/td>

dog<\/strong>

  • Both suppression values < 10 ng\/ml: Cushing's Syndrome unlikely.<\/li>
  • One suppression value < 10 ng\/ml: Cushing's Syndrome questionable.<\/li>
  • No sufficient suppression (suppression values > 10 ng\/ml): If the clinical symptoms are appropriate, this indicates the presence of Cushing\u00b4s Syndrome. Insufficient suppression can also be seen in the context of other diseases. If these cannot be excluded or treated, an ACTH stimulation test may be helpful.<\/li><\/ul>
    cat<\/strong>
    • Both suppression values < 10 ng\/ml: Cushing's Syndrome unlikely.<\/li>
    • One suppression value < 10 ng\/ml: Cushing's Syndrome questionable.<\/li>
    • Insufficient suppression: Lack of suppression with 0.1mg\/kg dexamethasone may indicate presence of Cushing\u00b4s Syndrome in cats with compatible clinical signs.<\/li><\/ul>
      horse<\/strong>
      • PPID: one or both suppression values > 10 ng\/ml<\/li>
      • Cave: In late summer\/autumn, healthy horses, too, possibly suppress insufficiently.<\/li><\/ul>guinea pig<\/strong>
        • Evaluation: adequate suppression and interpretation as in dogs, reference values not available. <\/li><\/ul><\/p><\/td><\/tr>
Remark<\/strong><\/td>

  • The test with examination of 2 suppression values (3 serum samples) can be found on the online submission forms and in the practice programmes under service ID 1142.<\/li>
  • PPID (pituitary pars intermedia dysfunction), formerly called Cushing's disease in horses<\/strong> is caused by \u201cpituitary adenoma\u201d (hyperplasia of the pars intermedia). The hyperplastic cells have no cortisol receptors, that is why in PPID, the exogenous administration of dexamethasone does not suppress the endogenous secretion of corticoids as it does in healthy horses.<\/li><\/ul><\/p><\/td><\/tr><\/table>\n","protected":false},"excerpt":{"rendered":"

    Dexamethasone Suppression Test (low dose) LABOKLIN Service ID: 142DiagnosisScreening test to confirm the diagnosis of Cushing\u2019s disease\/PPID (Horse)MaterialSerum 2 x 0.5 ml or 3 x 0.5 mlExecutiondog\/cat\/guinea pigFirst blood collection = baseline valueInjection of dexamethasonei.v. (or i.m.) dog: 0.01 mg\/kg i.m. or. i.v. guinea pig: 0.1 mg\/kg i.v. (or i.m.) cat: 0.1 mg\/kg Blood collection…<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":660000,"menu_order":11,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_seopress_robots_primary_cat":"","_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","footnotes":""},"class_list":["post-660012","page","type-page","status-publish","hentry","description-off"],"_links":{"self":[{"href":"https:\/\/laboklin.com\/en\/wp-json\/wp\/v2\/pages\/660012","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/laboklin.com\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/laboklin.com\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/laboklin.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/laboklin.com\/en\/wp-json\/wp\/v2\/comments?post=660012"}],"version-history":[{"count":1,"href":"https:\/\/laboklin.com\/en\/wp-json\/wp\/v2\/pages\/660012\/revisions"}],"predecessor-version":[{"id":1524254,"href":"https:\/\/laboklin.com\/en\/wp-json\/wp\/v2\/pages\/660012\/revisions\/1524254"}],"up":[{"embeddable":true,"href":"https:\/\/laboklin.com\/en\/wp-json\/wp\/v2\/pages\/660000"}],"wp:attachment":[{"href":"https:\/\/laboklin.com\/en\/wp-json\/wp\/v2\/media?parent=660012"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}