{"id":1211045,"date":"2022-09-06T10:55:09","date_gmt":"2022-09-06T08:55:09","guid":{"rendered":"https:\/\/staging.laboklin.com\/int\/primary-hyperoxaluria-ph"},"modified":"2021-12-02T09:22:27","modified_gmt":"2021-12-02T08:22:27","slug":"primary-hyperoxaluria-ph","status":"publish","type":"page","link":"https:\/\/laboklin.com\/en\/products\/genetics\/hereditary-diseases\/dog\/primary-hyperoxaluria-ph\/","title":{"rendered":"Primary hyperoxaluria (PH)"},"content":{"rendered":"<h3 class=\"csc-firstHeader\">Primary hyperoxaluria (PH)<\/h3><p><span>LABOKLIN Service ID: 8321<\/span><\/p><p class=\"bodytext\">The primary hyperoxaluria (PH) is a rare genetic disorder of the glyoxylate metabolism, which is necessary for the formation of endogenous glucose. Due to a point mutation the expression of the metabolic enzymes alanine-glyoxylate aminotransferase and glyoxylate reductase is decreased. Accumulation of oxalate and formation of calcium oxalate crystals in the urinary organs are a result of this disturbance. The resulting crystals are also taken up by the kidney tissue and can lead to decreased renal function.<\/p><table class=\"tx-laboklinleistung-table contenttable contenttable-2\" style=\"margin-top: 35px;\"><tr><td class=\"td-0\"><strong>Method<\/strong><\/td><td class=\"td-1\"><p class=\"bodytext\">sequencing<\/p><\/td><\/tr><tr><td class=\"td-0\"><strong>Breed list<\/strong><\/td><td class=\"td-1\"><p class=\"bodytext\">Coton de Tul\u00e9ar<\/p><\/td><\/tr><tr><td class=\"td-0\"><strong>Heredity<\/strong><\/td><td class=\"td-1\"><p class=\"bodytext\">autosomal recessive<\/p><\/td><\/tr><tr><td class=\"td-0\"><strong>Duration<\/strong><\/td><td class=\"td-1\"><p class=\"bodytext\">1 - 2 weeks after arrival of the sample in the lab<\/p><\/td><\/tr><\/table>\n","protected":false},"excerpt":{"rendered":"<p>Primary hyperoxaluria (PH)LABOKLIN Service ID: 8321The primary hyperoxaluria (PH) is a rare genetic disorder of the glyoxylate metabolism, which is necessary for the formation of endogenous glucose. Due to a point mutation the expression of the metabolic enzymes alanine-glyoxylate aminotransferase and glyoxylate reductase is decreased. Accumulation of oxalate and formation of calcium oxalate crystals in&hellip;<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":1211000,"menu_order":50,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_seopress_robots_primary_cat":"","_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","footnotes":""},"class_list":["post-1211045","page","type-page","status-publish","hentry","description-off"],"_links":{"self":[{"href":"https:\/\/laboklin.com\/en\/wp-json\/wp\/v2\/pages\/1211045","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/laboklin.com\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/laboklin.com\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/laboklin.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/laboklin.com\/en\/wp-json\/wp\/v2\/comments?post=1211045"}],"version-history":[{"count":0,"href":"https:\/\/laboklin.com\/en\/wp-json\/wp\/v2\/pages\/1211045\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/laboklin.com\/en\/wp-json\/wp\/v2\/pages\/1211000"}],"wp:attachment":[{"href":"https:\/\/laboklin.com\/en\/wp-json\/wp\/v2\/media?parent=1211045"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}