Hemorrhagic diathesis (Scott syndrome)

Hemorrhagic diathesis (Scott syndrome)

LABOKLIN Service ID: 8319

The Scott syndrome is a rare, autosomal-recessive, hemorrhagic diathesis in German Shepherds. The enhanced tendency to hemorrhage is caused by impaired coagulation activity, recognizable by activated platelets, which are not capable to present anionic phospholipids, particularly phosphatidylserine, and distribute coagulation microparticles. The presentation of phosphatidylserine on the surface of activated platelets is essential for the formation of the blood coagulation enzyme complexes. Other coagulation parameters are normal, with the exception of a reduced Prothrombin consumption during clotting of blood.