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		<title>2024 &#124; Publications English</title>
		<link>https://laboklin.com/en/2024-publications-english/</link>
		
		<dc:creator><![CDATA[Laboklin &#124; Bad Kissingen]]></dc:creator>
		<pubDate>Tue, 31 Dec 2024 08:44:13 +0000</pubDate>
				<category><![CDATA[2024]]></category>
		<category><![CDATA[Publications English]]></category>
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					<description><![CDATA[- Increased susceptibility to Mycobacterium avium complex infection in miniature Schnauzer...
- Clinical Signs in 166 Beagles with Different Genotypes of Lafora
- Frequency of potentially pathogenic bacterial and fungal isolates among...
- Isolation of aerobic bacteria from abscesses and wounds in rabbits and antibiotic...
- Allele frequency of a genetic risk variant for necrotizing meningoencepahlitis in pug dogs from Europe... 
....]]></description>
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			<p>Feuer L, Frenzer SK, Merle R, Leistner R, Bäumer W, Bethe A, Lübke-Becker A, Klein B, Bartel A.<br />
<strong>Prevalence of MRSA in canine and feline clinical samples from one-third of veterinary practices in Germany from 2019-2021.</strong><br />
J Antimicrob Chemother. 2024;79(9):2273-2280. doi: 10.1093/jac/dkae225.</p>
<div class="hr-thin"></div>
<p>Feuer L, Frenzer SK, Merle R, Bäumer W, Lübke-Becker A, Klein B, Bartel A.<br />
<strong>Comparative Analysis of Methicillin-Resistant <em>Staphylococcus pseudintermedius</em> Prevalence and Resistance Patterns in Canine and Feline Clinical Samples: Insights from a Three-Year Study in Germany.</strong><br />
Antibiotics (Basel). 2024;13(7):660. doi: 10.3390/antibiotics13070660.</p>
<div class="hr-thin"></div>
<p>Frenzer SK, Feuer L, Bäumer W, Lübke-Becker A, Klein B, Merle R.<br />
<strong>Temporal Trends in Antimicrobial Resistance of <em>Klebsiella pneumoniae</em> in Clinically Affected Canine and Feline Populations in Germany: A 2019–2021 Analysis.</strong><br />
Microbiology Research. 2024;15(3):1634-1644. doi: 10.3390/microbiolres15030108.</p>
<div class="hr-thin"></div>
<p>Leps AS, Klein B, Schneider M, Goericke-Pesch S.<br />
<strong>How Restrictive Legislation Influences Antimicrobial Susceptibility in Selected Bacterial Isolates from the Canine Vagina.</strong><br />
Antibiotics (Basel). 2024;13(10):946. doi: 10.3390/antibiotics13100946.</p>
<div class="hr-thin"></div>
<p>Frenzer SK, Feuer L, Bartel A, Bethe A, Lübke-Becker A, Klein B, Bäumer W, Merle R.<br />
<strong>Third-generation cephalosporin resistant Escherichia coli in dogs and cats in Germany in 2019-2021.</strong><br />
PLoS One. 2024;19(8):e0309554. doi: 10.1371/journal.pone.0309554.</p>
<div class="hr-thin"></div>
<p>MacLachlan N, Routh A, Hunt G, Barbon A, Haworth M, Miller J, Pocknell A, Price E,<br />
<strong>Diagnosis of Menopause in a Captive Sumatran Orangutan (<em>Pongo abelii</em>),</strong><br />
Zoo Biology, 2024; 1-5, <a href="https://doi.org/10.1002/zoo.21874">doi.org/10.1002/zoo.21874</a></p>
<div class="hr-thin"></div>
<p>Schäfer I, Binder F, Kerner K, Breu D, Müller E.<br />
<strong>Serological and molecular detection of <em>Toxoplasma gondii</em> in cats in Europe with evaluation of associated risk factors for pathogen contact/infection,</strong><br />
JFMS 2024, 26, 11, doi 10.1177/1098612X241281223</p>
<div class="hr-thin"></div>
<p>Jensen S, Kehl A, Giger U.<br />
<strong>European EHBP1L1 Genotyping Survey of Dyserythropoietic Anemia and Myopathy Syndrome in English Springer Spaniels.</strong><br />
<em>Vet. Sci.</em> 2024; <em>11</em>(12): 596, <a href="https://doi.org/10.3390/vetsci11120596">doi.org/10.3390/vetsci11120596</a></p>
<div class="hr-thin"></div>
<p>Axt C, Springer A, Besse A, Naucke T, Müller E, Strube C, Schäfer I.<br />
<strong>Equine granulocytic anaplasmosis (EGA): Case description and overview of the epidemiological situation with focus on Germany.</strong><br />
Tierarztl Prax Ausg G Grosstiere Nutztiere. 2024; 52: 352–60. doi: 10.1055/a-2418-6540</p>
<div class="hr-thin"></div>
<p>Axt CW, Springer A, von Luckner J, Naucke TJ, Müller E, Strube C, Schäfer I.<br />
<strong>Equine piroplasmosis: Case descriptions and overview of the epidemiological situation in Europe with focus on Germany.</strong><br />
Tierarztl Prax Ausg G Grosstiere Nutztiere 2024; online first. doi: 10.1055/a-2457-5516</p>
<div class="hr-thin"></div>
<p>Bartel A, Aupperle-Lellbach H, Kehl A, Weidle S, Aeschlimann L, Klopfleisch R, de Brot S.<br />
<strong>Expression of Mutated <em>BRAF<sup>V595E</sup></em> Kinase in Canine Carcinomas—An Immunohistochemical Study.</strong><br />
Vet. Sci. 2024 110 (584). doi.org/ 10.3390/vetsci11110584</p>
<div class="hr-thin"></div>
<p>Marschang RE, Schüler L.<br />
<strong>Adenoviruses and <em>Encephalitozoon pogonae</em> in samples from bearded dragons (<em>Pogona</em> spp.) in Europe.</strong><br />
Journal of Herpetological Medicine and Surgery. 2024; 34(4):262-6</p>
<div class="hr-thin"></div>
<p>Törner K, Aupperle-Lellbach H, Müller E, Naucke TJ, Schäfer I.<br />
<strong>Unexpected cytological detection of <em>Leishmania infantum</em> within the secretion of a canine mammary carcinoma.</strong><br />
Animals. 2024; 14: 2794. doi: 10.3390/ani14192794.</p>
<div class="hr-thin"></div>
<p>Kehl A, Aupperle-Lellbach H, de Brot S, van der Weyden L.<br />
<strong>Advances in molecular technologies for investigating cancer in canines,</strong><br />
Animals 2024; 14: 769. <a href="https://doi.org/10.3390/ani14050769">doi: 10.3390/ani14050769</a></p>
<div class="hr-thin"></div>
<p>Aeschlimann L, Kehl A, Guscetti F, Posthaus C, Aupperle-Lellbach H, Rottenberg S, de Brot S.<br />
<strong>Effective detection of BRAF V595E mutation in canine urothelial and prostate carcinomas using immunohistochemistry.</strong><br />
Vet Comp Oncol. 2024; 22:295-302. doi: 10.1111/vco.12978</p>
<div class="hr-thin"></div>
<p>Aupperle-Lellbach H, Kehl A, de Brot S, van der Weyden L.<br />
<strong>Clinical Use of Molecular Biomarkers in Canine and Feline Oncology: Current and Future.</strong><br />
Vet Sci.2024; 11: 199. doi: 10.3390/vetsci11050199</p>
<div class="hr-thin"></div>
<p>Schöniger S, Degner S, Schandelmaier C, Aupperle-Lellbach H, Zhang Q, Schildhaus HU.<br />
<strong>Immunohistochemical Detection of Indoleamine 2,3-Dioxygenase in Spontaneous Mammary Carcinomas of 96 Pet Rabbits.</strong><br />
Animals 2024; 14: 206. doi: 10.3390/ani14142060</p>
<div class="hr-thin"></div>
<p>Kehl A, Kuder H, Parkinson L, Koenig A, Langbein-Detsch I, Mueller E, Giger U.<br />
<strong><em>CMAH</em> coding sequence variants in 15 non-domestic felid species related to <em>ABC</em> blood group system.</strong><br />
Ani. 2024; 14: 2442. doi.10.3390/ani14162442</p>
<div class="hr-thin"></div>
<p>Rudd Garces G, Farke D, Schmidt MJ, Letko A, Schirl K, Abitbol M, Leeb T, Lyons LA, Lühken G.<br />
<strong>PAX3 haploinsufficiency in Maine Coon cats with dominant blue eyes and hearing loss resembling the human Waardenburg syndrome.</strong><br />
G3 journals. 2024; jkae131. doi: 10.10903/g3journal/jkai131.</p>
<div class="hr-thin"></div>
<p>Mizukami K, Dorsey-Oresto A, Raj K, Eringis A, Furrow E, Martin E, Yamanaka D, Kehl A, Kolicheski A, Jagannathan V, Leeb T, Lionakis MS, Giger U.<br />
<strong>Increased susceptibility to Mycobacterium avium complex infection in miniature Schnauzer dogs caused by a codon deletion in CARD9.</strong><br />
Sci Rep. 2024;14(1):10346. doi: 10.1038/s41598-024-61054-x.</p>
<div class="hr-thin"></div>
<p>Flegel T, Dirauf C, Kehl A, Dietzel J, Holtdirk A, Langbein-Detsch I, Müller E.<br />
<strong>Clinical Signs in 166 Beagles with Different Genotypes of Lafora.</strong><br />
Genes. 2024;15(1):122. doi: 10.3390/genes15010122</p>
<div class="hr-thin"></div>
<p>Köhne M, Hegger A, Tönissen A, Heusinger A, Hader C, Görgens A, Sieme H.<br />
<strong>Frequency of potentially pathogenic bacterial and fungal isolates among 28,887 endometrial samples from mares, with an emphasis on multi-drug resistant bacteria in Germany (2018-2022).</strong><br />
J Equine Vet Sci. 2024 Feb;133:105008. doi: 10.1016/j.jevs.2024.105008. Epub 2024 Jan 17. PMID: 38237703.</p>
<div class="hr-thin"></div>
<p>Schüler L, Lenz S, Mittenzwei F, Gletscher I, Müller E, Heckers K, Marschang RE.<br />
<strong>Ophidiomycosis in wild dice snakes (<em>Natrix tessellata</em>) in Germany.</strong><br />
J Herpetol Med Surg 2024; 34(1):11-15. doi: 10.5818/JHMS-D-23-00025</p>
<div class="hr-thin"></div>
<p>Hinderer J, Lüdeke J, Riege L, Bartel A, Kohn B, Müller E, Arlt S.<br />
<strong>Thyroid hormones in canine pregnancy and lactation.</strong><br />
Theriogenology. 2023; 203: 43-52. doi: <a href="https://doi.org/10.1016/j.theriogenology.2023.03.005">10.1016/j.theriogenology.2023.03.005</a></p>
<div class="hr-thin"></div>
<p>Christen M, Oevermann A, Rupp S, Vaz FM, Wever EJM, Braus BK, Jagannathan V, Kehl A, Hytonen MK, Lohi H, Leeb T.<br />
<strong>PCYT2 deficiency in Saarlooswolfdogs with progressive retinal, central, and peripheral neurodegeneration.</strong><br />
Mol Genet Metab. 2024 Mar;141(3):108149. doi: 10.1016/j.ymgme.2024.108149. Epub 2024 Jan 21. PMID: 38277988.</p>
<div class="hr-thin"></div>
<p>Parkinson L, Kuder H, Kehl A, Koenig A, Good J, Hausmann J, Giger U.<br />
<strong>NONDOMESTIC FELID <em>ABC</em> BLOOD PHENOTYPING, GENOTYPING, AND CROSSMATCHING.</strong><br />
J Zoo Wildl Med. 2024 Mar;55(1):143-154. doi: 10.1638/2023-0025. PMID: 38453497.</p>
<div class="hr-thin"></div>
<p>Axt C, Springer A, Strube C, Jung C, Naucke TJ, Müller E, Schäfer I.<br />
<strong>Molecular and serological detection of vector-borne pathogens responsible for equine piroplasmosis in Europe between 2008 and 2021</strong><u><strong>.</strong><br />
</u>Microorganisms. 2024; 12:816. doi: 10.3390/microorganisms12040816</p>
<div class="hr-thin"></div>
<p>Schwab M, Brockmann M, Stumpf P, Pfabe J, Müller E, Pees M, Marschang RE.<br />
<strong>Isolation of aerobic bacteria from abscesses and wounds in rabbits and antibiotic susceptibility testing of <em>Staphylococcus</em> spp. and <em>Pseudomonas </em>spp. Isolates.</strong><br />
Exot Pet Med. 2024; 49:41-47. doi. 10.1053/j.jepm.2024.03.009</p>
<div class="hr-thin"></div>
<p>Van Renen J, Kehl A, Buhmann G, Matiasek LA, Zablotski Y, Fischer A<em>.<br />
</em><strong>Allele frequency of a genetic risk variant for necrotizing meningoencepahlitis in pug dogs from Europe and association with the clinical phenotype.</strong><br />
Front. Vet. Sci. 11:1407288. doi: 10.3389/fvets.2024.1407288</p>
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		<title>2023 &#124; Publications English</title>
		<link>https://laboklin.com/en/2023-publications-english/</link>
		
		<dc:creator><![CDATA[Laboklin &#124; Bad Kissingen]]></dc:creator>
		<pubDate>Sat, 30 Dec 2023 11:18:00 +0000</pubDate>
				<category><![CDATA[2023]]></category>
		<category><![CDATA[Publications English]]></category>
		<guid isPermaLink="false">https://laboklin.com/?p=1470397</guid>

					<description><![CDATA[- Establishment of a Real-Time PCR Assay for the Detection of Devriesea agamarum in Lizards. 
- Infections with Hepatozoon canis in dogs living in Germany...
- In vitro efficacy of bacteriophages in companion animals. 
- Infectious agents found in in anaemic cats. Poster 
- Hematological values of red-eared sliders (Trachemys scripa elegans) in fall.

....]]></description>
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			<p>Villanueva‑Saz S, Martínez M, Nijhof AM, Gerst B, Gentil M, Müller E, Fernández A, González A, Yusuf MSM, Greco G, Verde M, Sgroi G, Lacasta D, Marteles D, Trotta M, Schäfer I.<br />
<strong>Molecular survey on vector‑borne pathogens in clinically healthy stray cats in Zaragoza (Spain). </strong><br />
Parasites &amp; Vectors. 2023;16:428, doi: 10.1186/s13071-023-06046-y.</p>
<div class="hr-thin"></div>
<p>Wong K, Abascal F, Ludwig L, Aupperle-Lellbach H, Grassinger J, Wright CW, Allison SJ, Pinder E, Phillips RM, Romero LP, Gal A, Roady PJ, Pires I, Guscetti F, Munday JS, Peleteiro MC, Pinto CA, Carvalho T, Cota J, Du Plessis EC, Constantino-Casas F, Plog S, Moe L, de Brot S, Bemelmans I, Amorim RL, Georgy SR, Prada J, Del Pozo J, Heimann M, de Carvalho Nunes L, Simola O, Pazzi P, Steyl J, Ubukata R, Vajdovich P, Priestnall SL, Suárez-Bonnet A, Roperto F, Millanta F, Palmieri C, Ortiz AL, Barros CSL, Gava A, Söderström ME, O&#8217;Donnell M, Klopfleisch R, Manrique-Rincón A, Martincorena I, Ferreira I, Arends MJ, Wood GA, Adams DJ, van der Weyden L.<br />
<strong>Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer. </strong><br />
Genome Biol. 2023;24(1):191. doi: 10.1186/s13059-023-03026-4.</p>
<div class="hr-thin"></div>
<p>Leineweber C, Lücht M, Gohl C, Steinmetz HW, Marschang RE.<br />
<strong>Clinical Chemistry and Haematology Values of a Captive Population of Humboldt Penguins (<em>Spheniscus humboldti</em>). </strong><br />
Animals (Basel). 2023;13(22):3570. doi: 10.3390/ani13223570.</p>
<div class="hr-thin"></div>
<p>Brockmann M, Mensing N, von Luckner J, Müller E, Kehl A.<br />
<strong>Hemophilia A in a litter of Border Collies caused by a one base pair deletion in the F8 gene. </strong><br />
Vet Clin Pathol. 2023;52(4):607-12. doi: 10.1111/vcp.13312.</p>
<div class="hr-thin"></div>
<p>Schneider M, Heusinger A, Klein BU, Müller E.<br />
<strong>Retrospective Evaluation of Bacteriological Results of Canine Cerebrospinal Fluids from 2020 to 2022.</strong><br />
Poster presented at the SEVC (Southern European Veterinary Congress); 2023 Nov 09-11; Barcelona, Spain.</p>
<div class="hr-thin"></div>
<p>Gentil M, Matiasek K, Rubbenstroth D, Müller E.<br />
<strong>Detection of Rustrela virus, an emerging neuropathogen of mammals, in CSF of a cat.</strong><br />
Poster presented at the SEVC (Southern European Veterinary Congress); 2023 Nov 09-11; Barcelona, Spain.</p>
<div class="hr-thin"></div>
<p>Villanueva Saz S, Martínez M, Nijhof AM, <u>Gentil M</u>, <u>Müller E</u>, Fernández A, González A, Mohamud Yusuf MSh, Greco G, Verde M, Lacasta D, Trotta M, <u>Schäfer I.<br />
</u><strong>Molecular survey on vector-borne pathogens in clinically healthy feral cats in Zaragoza (Spain) including analysis of potential risk factors for infections: sex and coinfections.</strong><br />
Poster presented at the SEVC (Southern European Veterinary Congress); 2023 Nov 09-11; Barcelona, Spain.</p>
<div class="hr-thin"></div>
<p>Schäfer, I; Helm, CS; von Samson-Himmelstjerna, G; Krücken, J; Kottmann, T; Holtdirk, A; Kohn, B, Hendrickx, G; Marsboom, C; Müller, E.<br />
<strong>Molecular detection of <em>Babesia </em>spp. in dogs in Germany (2007–2020) and identification of potential risk factors for infection.</strong><br />
Parasit Vectors. 2023;16(1):396. doi: 10.1186/s13071-023-06005-7.</p>
<div class="hr-thin"></div>
<p>Kreilmeier-Berger T, Aupperle-Lellbach H, Reifinger M, Valentin Hörstke N, Holzmann K, Kleiter M.<br />
<strong>Alternative Lengthening of Telomeres Is Rare in Canine Histiocytic Sarcoma.</strong><br />
Cancers. 2023;15(17):4214. doi: 10.3390/ cancers15174214.</p>
<div class="hr-thin"></div>
<p>Pees M, Brockmann M, Steiner N, Marschang RE.<br />
<strong><em>Salmonella</em> in reptiles: a review of occurrence, interactions, shedding and risk factors for human infections.</strong><br />
Front Cell Dev Biol. 2023;11:1251036. doi: 10.3389/fcell.2023.1251036.</p>
<div class="hr-thin"></div>
<p>Kruppenbacher AS, Müller E, Ardema ML, Schäfer I, von Loewenich FD.<br />
<strong>Granulocytic anaplasmosis in cats from central Europe and molecular characterization of feline <em>Anaplasma phagocytophilum</em> strains by ankA gene, groEL gene and multilocus sequence typing.</strong><br />
Parasites &amp; Vectors. 2023;16:348. doi: 10.1186/s13071-023-05954-3.</p>
<div class="hr-thin"></div>
<p>Heusinger, A.<br />
<strong>Autogenous vaccines for dogs and cats.</strong><br />
Manual of autogenous vaccines. 2023; 219-224. https://www.emav.be/publications.</p>
<div class="hr-thin"></div>
<p>Lapsina S, Nagler N, Müller SF, Holtdirk A, Kottmann T, Müller E, Schäfer I.<br />
<strong>Fibroblast Growth Factor-23 (FGF-23) in dogs—Reference interval and correlation with hematological and biochemical parameters.</strong><br />
Animals. 2023;13(20):3202. doi: 10.3390/ani13203202.</p>
<div class="hr-thin"></div>
<p>Pénzes JJ, Tarján ZL, Kaján GL, Berta P, Szirovicza L, T´th A, Ball I, Doszoply A, <u>Marschang RE</u>, Benkö M, Harrach B, Papp T.<br />
<strong>Reptile adenoviruses, genes and genomes with bourgioning variability; an update.</strong><br />
Oral presentation at the 15<sup>th</sup> International Adenovirus Meeting; 2023 Sep 24-28; Brač Island, Croatia.</p>
<div class="hr-thin"></div>
<p>Breu D, Wenk C, Müller E.<br />
<strong>Seroprevalence of toxoplasma-specific antibodies in 6131 European cats (2021-2022).</strong><br />
Poster presented at the 33<sup>rd</sup> Annual congress of the European College of Veterinary Internal Medicine (ECVIM); 2023 Sep 21 – 23, Barcelona, Spain.</p>
<div class="hr-thin"></div>
<p>Turchetto S, Mikinac I, Aupperle-Lellbach H.<br />
<strong>FATAL RHABDOMYOSARCOMA IN A ONE-YEAR-OLD DOG.</strong><br />
Poster presented at ESVP/ECVP/ESVCP/ECVCP Joint Congress; 2023 Aug 30 &#8211; Sept 02; Lisbon, Portugal.</p>
<div class="hr-thin"></div>
<p>Cerezo-Echevarria A, Kehl A, Beitzinger C, Müller T, Klopfleisch R and Aupperle-Lellbach H.<br />
<strong>Correlation between malignant histological features of canine digital Squamous cell Carcinoma and genetic KIT Ligand copy number variation.</strong><br />
ESVP/ECVP/ESVCP/ECVCP Joint Congress; 2023 Aug 30 &#8211; Sept 02; Lisbon, Portugal.</p>
<div class="hr-thin"></div>
<p>Törner K, Beitzinger C, Van de Weyer A, Kempker K, Aupperle-Lellbach H.<br />
<strong>INCIDENCE OF GENETIC VARIANTS IN SELECTED CANINE CARDIOMYOPATHIES IN SEVERAL BREEDS.</strong><br />
Poster session presented at ESVP/ECVP/ESVCP/ECVCP Joint Congress; 2023 Aug 30 &#8211; Sept 02; Lisbon, Portugal.</p>
<div class="hr-thin"></div>
<p>Christian M, Wagner R, Kahnt E.<br />
<strong>Pilot study on the storage stability of allergen-specific IgE against house dust and storage mites in serum of dogs.</strong><br />
Poster session presented at 34th European Veterinary Dermatology Congress (ESVD-ECVD); 2023 Aug 31 – Sep 02; Gothenburg, Sweden.</p>
<div class="hr-thin"></div>
<p>Davoodi A, Christian M, Wagner R.<br />
<strong>The rate of negative perennial serum allergy tests in different dog breeds – a retrospective study.</strong><br />
Poster session presented at 34th European Veterinary Dermatology Congress (ESVD-ECVD); 2023 Aug 31 – Sep 02; Gothenburg, Sweden.</p>
<div class="hr-thin"></div>
<p>Kehl A, Almeida Fonseca J, Baneth G, Di Muccio T, Müller E, Schäfer I.<br />
<strong>Resistance of <em>Leishmania infantum</em> to allopurinol in dogs in Europe – a digital droplet PCR assay for quantifying S-adenosylmethionine synthetase (<em>METK</em>) gene copy number.</strong><br />
Poster presented at the 33<sup>rd</sup> Annual congress of the European College of Veterinary Internal Medicine (ECVIM); 2023 Sep 21 – 23, Barcelona, Spain.</p>
<div class="hr-thin"></div>
<p>Schäfer I, Nagler N, Müller SF, Holtdirk A, Kottmann T, Müller E.<br />
<strong>Association of Fibroblast Growth Factor-23 (FGF-23) with parameters of renal dysfunction in dogs and cats.</strong><br />
Poster presented at the 33<sup>rd</sup> Annual congress of the European College of Veterinary Internal Medicine (ECVIM); 2023 Sep 21 – 23, Barcelona, Spain.</p>
<div class="hr-thin"></div>
<p>Schneider AM, Heusinger A, Müller E, Marschang RE.<br />
<strong>BACTERIA AND ANTIMICROBIAL SUSCEPTIBILITY FROM CANINE LIQUOR SAMPLES OVER A 3 YEAR PERIOD.</strong><br />
Poster presented at the 5th ICECVM; 2023 Sep 21 – 23, Bled, Slovenia.</p>
<div class="hr-thin"></div>
<p>Marschang RE, Möller A, Schmidt V, Schroedl W, Pees M.<br />
<strong>Species specific reaction to infection with a highly virulent ferlavirus: Comparison in corn snakes (<em>Pantherophis guttatus</em>) and ball pythons (<em>Python regius</em>).</strong><br />
Oral presentation on the <em>5<sup>th</sup> ICECVM</em><em>;</em><em> 2023</em><em> Sep 21 – 23, </em><em>Bled, Slovenia</em></p>
<div class="hr-thin"></div>
<p>Klein B.<br />
<strong>How to save antibiotics – the benefit of cumulative antibiograms.</strong><br />
Oral presentation on the 48<sup>th</sup> World Small Animal Veterinary Association Congress and the 28<sup>th</sup> FECAVA Eurocongress (WSAVA 2023), 2023 Sep 27 – 29, Lisbon, Portugal.</p>
<div class="hr-thin"></div>
<p>Marschang RE.<br />
<strong>A short overview of paramyxovirus infections in reptiles.</strong><br />
Oral presentation on the <em>Yaboumba conference</em><em>;</em><em> 2023</em><em> Sep 29 – 30,</em><em> Paris, France</em><em>.</em></p>
<div class="hr-thin"></div>
<p>Marschang RE, Brockmann M, Leineweber C, Hellebuyck T, Martel A, Pasmans F, Gentil M, Müller E.<br />
<strong>A real-time PCR for the detection of </strong><em><strong>Devriesea agamarum.</strong><br />
</em>Oral presentation on the <em>Yaboumba conference</em><em>;</em><em> 2023</em><em> Sep 29 – 30,</em><em> Paris, France</em><em>.</em></p>
<div class="hr-thin"></div>
<p>Varga-Kugler R, Ihász K, Marton S, Kaszab E, Marschang RE, Farkas S, Bányai K.<br />
<strong>Genetic diversity among reptilian orthoreoviruses isolated from pet snakes and lizards.</strong><br />
Front Vet Sci. 2023;10:1058133. doi: 10.3389/fvets.2023.1058133.</p>
<div class="hr-thin"></div>
<p>Küchler L, Posthaus C, Jäger K, Guscetti F, van der Weyden L, von Bomhard W, Schmidt JM, Farra D, Aupperle-Lellbach H, Kehl A, Rottenberg S, de Brot S.<br />
<strong>Artificial Intelligence to Predict the BRAF V595E Mutation in Canine Urinary Bladder Urothelial Carcinomas.</strong><br />
Animals. 2023;13:2404. doi:10.3390/ani13152404.</p>
<div class="hr-thin"></div>
<p>Schäfer I, Peukert A, Kerner K, Müller E.<br />
<strong>Vector-Borne Pathogens in Stray Cats in Eastern Germany (Thuringia).</strong><br />
Animals. 2023;13(16): 2574. doi.org/10.3390/ani13162574.</p>
<div class="hr-thin"></div>
<p>Marschang RE, Schüler L.<br />
<strong>Adenoviruses and <em>Encephalitozoon pogonae</em> in samples from bearded dragons (<em>Pogona</em> spp.) in Europe.</strong><br />
Oral presentation at Exoticscon; 2023 Aug 20-24; Boston, USA.</p>
<div class="hr-thin"></div>
<p>Leineweber C, Müller E, Marschang RE.<br />
<strong>Co-infections with respiratory pathogens in snakes.</strong><br />
Oral presentation at Exoticscon; 2023 Aug 20-24; Boston, USA.</p>
<div class="hr-thin"></div>
<p>Pees M, Möller A, Schmidt V, Schroedl W, Marschang RE.<br />
<strong>The role of host species in experimental ferlavirus infection: Comparison of a single strain in ball pythons (<em>Python regius</em>) and corn snakes (<em>Pantherophis guttatus</em>).</strong><br />
<em>Animals. </em>2023;<em>13</em>(17):2714; doi: 10.3390/ani13172714.</p>
<div class="hr-thin"></div>
<p>Kempker L, Aupperle-Lellbach H, Pocknell A, Van de Weyer AL, Kempker K, Beitzinger C.<br />
<strong>The good, the bad and the breeder – Development of genetic HCM-variants in cat populations from routine testing in the last 10 years.<br />
</strong>Poster presented at the 33<sup>rd</sup> Annual congress of the European College of Veterinary Internal Medicine (ECVIM); 2023 Sep 21 – 23, Barcelona, Spain.</p>
<div class="hr-thin"></div>
<p>Schneider AM, Heusinger A, Müller E, Marschang RE.<br />
<strong>BACTERIA AND ANTIMICROBIAL SUSCEPTIBILITY FROM CANINE LIQUOR SAMPLES OVER A 3 YEAR PERIOD.</strong><br />
Poster presented at the 5th ICECVM; 2023 Sep 21 – 23, Bled, Slovenia.</p>
<div class="hr-thin"></div>
<p>Schäfer I, Nagler N, Müller SF, Holtdirk A, Kottmann T, Müller E, von Luckner J.<br />
<strong>COMPARISON OF THREE DIFFERENT DIAGNOSTIC ASSAYS FOR DETERMINATION OF THE FIBROBLAST GROWTH FACTOR-23 (FGF-23) IN CATS: A PILOT STUDY.</strong><br />
Poster session presented at 2023 ISFM Feline Congress. 2023 Jun 29 -Jul 02; Dublin, Ireland.</p>
<div class="hr-thin"></div>
<p>Schäfer I, Schmidt A, Gräßer F, Schieszler A, Aupperle-Lellbach H, Loesenbeck G, Gentil M, Müller E, Naucke TJ, von Luckner J.<br />
<strong>FELINE LEISHMANIOSIS WITH FOCUS ON OCULAR MANIFESTATION: A CASE REPORT.</strong><br />
Poster session presented at 2023 ISFM Feline Congress. 2023 Jun 29 -Jul 02; Dublin, Ireland.</p>
<div class="hr-thin"></div>
<p>Pawlus E, Kehl A, Kuehnlein P, Mueller E.<br />
<strong>FREQUENCY OF <em>MDR1 (ABCB1)</em> VARIANT IN CATS.</strong><br />
Poster session presented at 2023 ISFM Feline Congress. 2023 Jun 29 -Jul 02; Dublin, Ireland</p>
<div class="hr-thin"></div>
<p>Aupperle-Lellbach H, Heidrich D, Conrad D Beitzinger C, Masala N, Klopfleisch R, Müller T.<br />
<strong>Comparative Study of Digital Squamous Cell Carcinoma in Giant, Standard, and Miniature Schnauzers.</strong><br />
Animals 2023;13(12):1990. doi: 10.3390/ani13121990.</p>
<div class="hr-thin"></div>
<p>Bismarck D, Gärtner TE, Hoffknecht ML, Heusinger A, Müller E.<br />
<strong>Antimicrobial activity of eleven essential oils against otitis-associated staphylococci and streptococci isolated from canine ears.</strong><br />
Poster session presented at the 71st International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA); 2023 Jul 2-5; Dublin, Ireland.</p>
<div class="hr-thin"></div>
<p>Leineweber C, Marschang RE.<br />
<strong>Report on the first Global Amphibian and Reptile Disease (GARD) Conference 2022.</strong><br />
Journal of Herpetological Medicine and Surgery. 2023;33(2):121-9. doi: 10.5818/JHMS-D-23-00001.</p>
<div class="hr-thin"></div>
<p>Idalan N, Müller E, Giger U.<br />
<strong>The Indirect Antiglobulin (Coombs’) Test Is Specific but Less Sensitive Than the Direct Antiglobulin Test for Detecting Anti-Erythrocytic Autoantibodies and Thereby Immune-Mediated Hemolytic Anemia in Dogs.</strong><br />
<em>Vet Sci.</em> 2023<em>;10(7)</em>:415. doi: 10.3390/vetsci10070415.</p>
<div class="hr-thin"></div>
<p>Kalbhenn EM, Pez N, Beyer W, Müller E.<br />
<strong>Efficacy of bacteriophages in companion animals.</strong><br />
Poster session presented at Viruses of Microbes; 2023 Jul 03-07; Tiblisi, Georgia.</p>
<div class="hr-thin"></div>
<p>Schwensow N.<br />
<strong>Beyond SNPs – Calling Structural Variants in NGS Routine.</strong><br />
Oral presentation at 39th International Society for Animal Genetics Conference (ISAG); 2023 Jul 02-07; Cape Town, South Africa.</p>
<div class="hr-thin"></div>
<p>Attipa C, Gunn-Moore D, Mazeri S, Epaminondas D, Lyraki M, Hardas A, Loukaidou S, Gentil M.<br />
<strong>Concerning feline infectious peritonitis outbreak in Cyprus.</strong><br />
Vet Record. 2023;192(11): 449-50, doi: 10.1002/vetr.3143.</p>
<div class="hr-thin"></div>
<p>Lagrange J, Amat JP, Ballesteros C, Damborg P, Grönthal T, Haenni M, Jouy E, Kaspar H, Kenny K, Klein B, Lupo A, Madec JY, Salomonsen CM, Müller E, Madero CM, Nilsson O, Norström M, Nykäsenoja S, Overesch G, Pedersen K, Pohjanvirta T, Slowey R, Justo CT, Urdahl AM, Zafeiridis C, Zini E, Cazeau G, Jarrige N, Collineau L.<br />
<strong>Pilot testing the EARS-Vet surveillance network for antibiotic resistance in bacterial pathogens from animals in the EU/EEA.</strong><br />
Front Microbiol. 2023;14:1188423. doi: 10.3389/fmicb.2023.1188423.</p>
<div class="hr-thin"></div>
<p>Faulhaber M, Müller E, Marschang RE.<br />
<strong>Detection of mycoplasma in Viperidae, Elapidae, and Lamprophiidae.</strong><br />
Poster presented at the Zoo and Wildlife Health Conference (EAZWV); 2023 Jun 07-10; Valencia, Spain.</p>
<div class="hr-thin"></div>
<p>Conrad D, Kehl A, Müller T, Klopfleisch R, Aupperle-Lellbach H.<br />
<strong>Immunohistochemical and Molecular Genetic Analysis of Canine Digital Mast Cell Tumours.</strong><br />
Animals. 2023;13(10),1694. doi.org/10.3390/ani13101694.</p>
<div class="hr-thin"></div>
<p>Bauer H.<br />
<strong>Mendelian and modern genetics – risk markers, parentage and genetic diversity: HCM in cats, DNA Profile in dogs, SNP Markers for DNA Profiles, blood groups in cats.</strong><br />
Oral presentation at congress of Slovenian Association of Small Veterinarians SZVMŽ; 2023 June 3 – 4; Kope, Slovenia</p>
<div class="hr-thin"></div>
<p>Heinonen T, Flegel T, Müller H, Kehl A, Hundi S, Matiasek K, Fischer A, Donner J, Forman OP, Lohi H, Hytönen MK.<br />
<strong>A loss-of-function variant in canine <em>GLRA1</em> associates with a neurological disorder resembling human hyperekplexia.</strong><br />
Hum Genet. 2023; May 24. doi: 10.1007/s00439-023-02571-z. Epub ahead of print.</p>
<div class="hr-thin"></div>
<p>Schäfer I, Schmidt A, Gräßer F, Schieszler A, Aupperle‑Lellbach H, Loesenbeck G, Gentil M, Müller E, Naucke TJ.<br />
<strong>Feline leishmaniosis with focus on ocular manifestation: a case report.</strong><br />
Parasit Vectors. 2023;16(1):161. doi: 10.1186/s13071-023-05741-0.</p>
<div class="hr-thin"></div>
<p>Schäfer I, Rehbein S, Holtdirk A, Kottmann T, Klein R, Müller E, Thoren-Tolling K.<br />
<strong>Diagnostic cut-off values for the urinary corticoid:creatinine ratio for the diagnosis of canine Cushing&#8217;s syndrome using an automated chemiluminescent assay.</strong><br />
Vet Clin Pathol. 2023;00:1–9. doi 10.1111/vcp.13219. (online first).</p>
<div class="hr-thin"></div>
<p>Lapsina S, Nagler N, Müller SF, Holtdirk A, Kottmann T, Müller E, von Luckner J, Schäfer I.<br />
<strong>Comparison of Three Different Diagnostic Assays for Fibroblast Growth Factor-23 (FGF-23) Measurements in Cats: A Pilot Study.</strong><br />
Animals. 2023;13(11):1853. doi: 10.3390/ani13111853.</p>
<div class="hr-thin"></div>
<p>Zborilova H, Dietz J, Heckers KO, Dvorakova R, Knotek Z, Cermakova E.<br />
<strong>Malignant ovarian dysgerminoma in a 16-year-old leopard gecko (Eublepharis macularius).</strong><br />
Veterinarni Medicina. 2023;68(03):129–34. doi: 10.17221/107/2022-VETMED.</p>
<div class="hr-thin"></div>
<p>Leineweber C, Müller E, Cian F, Marschang RE.<br />
<strong>Detection of nidoviruses (subfamily <em>Serpentovirinae</em>) in swabs of captive snakes in the United Kingdom between 2018 and 2021.</strong><br />
Poster session presented at BSAVA Congress; 2023 Mar 23-25; Manchester, UK.</p>
<div class="hr-thin"></div>
<p>Leps A, Klein B, Meyer C, Simon, C, Goericke-Pesch S.<br />
<strong>Vaginal flora of the bitch: a retrospective data analysis.</strong><br />
Reprod Dom Anim. 2023;58(Suppl. 1):24. doi: 10.1111/rda.14313.</p>
<div class="hr-thin"></div>
<p>Leps A, Klein B, Meyer C, Simon, C, Goericke-Pesch S.<br />
<strong>Vaginal flora of the bitch: a retrospective data analysis.</strong><br />
J Reproduktionsmed Endokrinol. 2023;20(1):16.</p>
<div class="hr-thin"></div>
<p>Leps A, Klein B, Meyer C, Simon, C, Goericke-Pesch S.<br />
<strong>Vaginal flora of the bitch: a retrospective data analysis.</strong><br />
Poster session presented at 56th Annual Conference of Physiology and Pathology of Reproduction and 48th Joint Conference of Veterinary and Human Reproductive Medicine; 2023 Mar 01–03; Münster, Germany.</p>
<div class="hr-thin"></div>
<p>Burde S, Lotze R, Törner K.<br />
<strong>Immunophenotyping of two horses with lymphoproliferative neoplasia.</strong><br />
Poster session presented at ESVONC 2023; May 25, Alicante, Spain</p>
<div class="hr-thin"></div>
<p>Brockmann M, Leineweber C , Hellebuyck T, Martel A, Pasmans F, Gentil M, Müller EM, Marschang RE.<br />
<strong>Establishment of a Real-Time PCR Assay for the Detection of <em>Devriesea agamarum</em> in Lizards.</strong><br />
Animals. 2023;13(5):881. doi: 10.3390/ani13050881.</p>
<div class="hr-thin"></div>
<p>Schäfer I, Naucke TJ, Marsboom C, Hendrickx G, Müller E.<br />
<strong>Infections with<em> Hepatozoon canis </em>in dogs living in Germany (2007-2021).</strong><br />
Poster session presented at BSAVA Congress; 2023 Mar 23-25; Manchester, UK.</p>
<div class="hr-thin"></div>
<p>Schäfer I, Fischer S, Silaghi C, Kohn B, Marsboom C, Hendrickx G, Gehlen H, Müller E.<br />
<strong>Molecular detection of<em> Anaplasma phagocytophilum </em>in dogs and horses from Germany (2008-2021).</strong><br />
Poster session presented at 15<sup>th</sup> International Symposium on Ticks and Tick-borne Diseases; 2023 Mar 29-31. Weimar.</p>
<div class="hr-thin"></div>
<p>Kalbhenn EM, Klein KS, Beyer W, Müller E.<br />
<strong><em>In vitro</em> efficacy of bacteriophages in companion animals.</strong><br />
Oral presentation at BSAVA Congress; 2023 Mar 23-25; Manchester, UK.</p>
<div class="hr-thin"></div>
<p>Kerner, E.-M. Kaiser, C. Hetterich, E. Müller.<br />
<strong>Infectious agents found in in anaemic cats.</strong><br />
Poster session presented at BSAVA Congress 2023; Mar 23-25; Manchester, UK.</p>
<div class="hr-thin"></div>
<p>Weingart C, Helm CS, Müller E, Schäfer I, Skrodzki M, von Samson-Himmelstjerna G, Krücken J, Kohn B.<br />
<strong>Autochthonous Babesia canis infections in 49 dogs in Germany.</strong><br />
J Vet Intern Med. 2023;37(1):140-149. doi: 10.1111/jvim.16611.</p>
<div class="hr-thin"></div>
<p>Leineweber C, Stöhr AC, Öfner S, Mathes K, Marschang RE.<br />
<strong>Hematological values of red-eared sliders (<em>Trachemys scripa elegans</em>) in fall.</strong><br />
Journal of Herpetological Medicine and Surgery. 2023;33(1):35-39. doi: 10.5818/JHMS-D-22-00030.</p>
<div class="hr-thin"></div>
<p>Leineweber C, Marschang RE.<br />
<strong>Detection rates of nidoviruses in samples from captive snakes in Europe between 2016 and 2021.</strong><br />
Vet Rec. 2023;e2588. doi: 10.1002/vetr.2588</p>
<div class="hr-thin"></div>
<p>Schäfer I, Kohn B, Silaghi C, Fischer S, Marsboom C, Hendrickx G, Müller E.<br />
<strong>Molecular and serological detection of <em>Anaplasma phagocytophilum</em> in dogs from Germany (2008-2020).</strong><br />
Animals. 2023;13(4):720 (online first). doi: 10.3390/ani13040720.</p>
<div class="hr-thin"></div>
<p>Cerezo-Echevarria A, Kehl A, Beitzinger C, Müller T, Klopfleisch R, Aupperle-Lellbach H.<br />
<strong>Evaluating the Histologic Grade of Digital Squamous Cell Carcinomas in Dogs and Copy Number Variation of KIT Ligand—A Correlation Study.</strong><br />
Vet Sci. 2023;10(2):88. doi:10.3390/vetsci10020088.</p>
<div class="hr-thin"></div>
<p>Kehl A, Valkai M, Van de Weyer A-L, Brockmann M, Steiger K, Schusser B, Aupperle-Lellbach H.<br />
<strong>iRNA Profiles of Canine Intestinal Carcinomas, Lymphomas and Enteritis Analysed by Digital Droplet PCR from FFPE Material.</strong><br />
Vet Sci. 2023;10(2):125. doi:10.3390/vetsci10020125.</p>
<div class="hr-thin"></div>
<p>Aupperle-Lellbach H, Heidrich D, Kehl A, Conrad D, Brockmann M, Törner K, Beitzinger C, Müller T.<br />
<strong>KITLG Copy Number Germline Variations in Schnauzer Breeds and Their Relevance in Digital Squamous Cell Carcinoma in Black Giant Schnauzers.</strong><br />
Vet Sci. 2023;10(2):147. doi:10.3390/vetsci10020147.</p>
<div class="hr-thin"></div>
<p>Szatmári V, Dirven M, Aupperle-Lellbach H.<br />
<strong>Progressive Right Ventricular Obstruction Caused by a Double-Chambered Right Ventricle Resulting in Shunt-Reversal via a Concomitant Congenital Ventricular Septal Defect and Subsequent Erythrocytosis in a Dog.</strong><br />
Vet Sci. 2023;10(3):174. doi:10.3390/vetsci10030174.</p>
<div class="hr-thin"></div>
<p>Kablau A, Erler S, Eckert JH, Pistorius J, Sharbati S, Einspanier R.<br />
<strong>Effects of Flupyradifurone and Two Reference Insecticides Commonly Used in Toxicological Studies on the Larval Proteome of the Honey Bee Apis mellifera.</strong><br />
Insects. 2023;14(1):77. doi: 10.3390/insects14010077.</p>
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		<title>2022 &#124; Publications English</title>
		<link>https://laboklin.com/en/2022-publications-english/</link>
		
		<dc:creator><![CDATA[Laboklin &#124; Bad Kissingen]]></dc:creator>
		<pubDate>Thu, 22 Dec 2022 14:30:13 +0000</pubDate>
				<category><![CDATA[2022]]></category>
		<category><![CDATA[Publications English]]></category>
		<guid isPermaLink="false">https://staging-wp-int.laboklin.com/?p=1447559</guid>

					<description><![CDATA[- Tumour Incidence in Dogs in Germany...
- Molecular Genetic Investigation of Digital Melanoma in Dogs.
- Pathological Findings in Gastrointestinal Neoplasms and Polyps in 860 Cats and a Pilot Study on miRNA Analyses.
- First evidence of vertical Hepatozoon canis transmission in dogs in Europe.
- Metabolomic serum abnormalities in dogs with hepatopathies.
...]]></description>
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			<p>Aupperle-Lellbach H, Grassinger JM, Floren A, Törner K, Beitzinger C, Loesenbeck G, Müller T.<br />
<strong>Tumour Incidence in Dogs in Germany: a Retrospective Analysis of 109,616 Histopathological Diagnoses (2014-2019).</strong><br />
J Comp Pathol. 2022;198:33-55. doi: 10.1016/j.jcpa.2022.07.009.</p>
<div class="hr-thin"></div>
<p>Conrad D, Kehl A, Beitzinger C, Metzler T, Steiger K, Pfarr N, Fischer K, Klopfleisch R, Aupperle-Lellbach H.<br />
<strong>Molecular Genetic Investigation of Digital Melanoma in Dogs.</strong><br />
Vet Sci. 2022;9(2):56. doi: 10.3390/vetsci9020056.</p>
<div class="hr-thin"></div>
<p>Kehl A, Törner K, Jordan A, Lorenz M, Schwittlick U, Conrad D, Steiger K, Schusser B, Aupperle-Lellbach H.<br />
<strong>Pathological Findings in Gastrointestinal Neoplasms and Polyps in 860 Cats and a Pilot Study on miRNA Analyses.</strong><br />
Vet Sci. 2022;9(9):477. doi: 10.3390/vetsci9090477.</p>
<div class="hr-thin"></div>
<p>Schäfer I, Müller E, Nijhof AM, Aupperle-Lellbach H, Loesenbeck G, Cramer S, Naucke TJ.<br />
<strong>First evidence of vertical Hepatozoon canis transmission in dogs in Europe.</strong><br />
Parasit Vectors. 2022;15(1):296. doi: 10.1186/s13071-022-05392-7.</p>
<div class="hr-thin"></div>
<p>Oberkersch LE, Schuberth HJ, Weber C, Freise F, Venner M.<br />
<strong>Kinetik of the IgG concentration in the blood of neonatal foals – comparison of foals with focal infectious diseases with healthy foals.</strong><br />
Pferdeheilkunde. 2022;38(2):134–141. English. doi: 10.21836/PEM20220205.</p>
<div class="hr-thin"></div>
<p>Imbery CA, Dieterle F, Ottka C, Weber C, Schlotterbeck G, Müller E, Lohi H, Giger U.<br />
<strong>Metabolomic serum abnormalities in dogs with hepatopathies.</strong><br />
Sci Rep. 2022;2(1):5329. doi: 10.1038/s41598-022-09056-5.</p>
<div class="hr-thin"></div>
<p>Bismarck D, Becker J, Müller E, Becher V, Nau L, Mayer P.<br />
<strong>Screening of Antimicrobial Activity of Essential Oils against Bovine Respiratory Pathogens &#8211; Focusing on Pasteurella multocida.</strong><br />
Planta Med. 2022;88(3-04):274-81. doi: 10.1055/a-1726-9291.</p>
<div class="hr-thin"></div>
<p>Adler JM, Weber C, Wernike K, Michelitsch A, Friedrich K, Trimpert J, Beer M, Kohn B, Osterrieder K, Müller E.<br />
<strong>Prevalence of anti-severe acute respiratory syndrome coronavirus 2 antibodies in cats in Germany and other European countries in the early phase of the coronavirus disease-19 pandemic.</strong><br />
Zoonoses Public Health. 2022;69(5):439-50. doi: 10.1111/zph.12932.</p>
<div class="hr-thin"></div>
<p>Leineweber C, Lücht M, Reese L, Marschang RE, Gohl C.<br />
<strong>COMPARISON OF CLINICAL CHEMISTRY ANALYTES IN GREATER FLAMINGOS (<em>PHOENICOPTERUS ROSEUS</em>) AND AMERICAN FLAMINGOS (<em>PHOENICOPTERUS RUBER</em>) IN A ZOO IN EUROPE.</strong><br />
J Zoo Wildl Med. 2022;53(1):187-93. doi: 10.1638/2019-0196.</p>
<div class="hr-thin"></div>
<p>Leineweber C, Öfner S, Mathes K, Piepho HP, Marschang RE, Stöhr AC. Thyroid<br />
<strong>Hormone Concentrations in Testudo spp. by Season and Sex. Journal of Herpetological Medicine and Surgery.</strong><br />
2022;32(1):84-95. doi: 10.5818/JHMS-D-21-00025.</p>
<div class="hr-thin"></div>
<p>Imbery CA, Dieterle F, Ottka C, Weber C, Schlotterbeck G, Müller E, Lohi H, Giger U.<br />
<strong>Metabolomic Abnormalities in Serum from Untreated and Treated Dogs with Hyper- and Hypoadrenocorticism.</strong><br />
Metabolites. 2022;12(4):339. doi: 10.3390/metabo12040339.</p>
<div class="hr-thin"></div>
<p>Schäfer I, Weber C, Gehlen H, Müller E.<br />
<strong>Incidence of tick-borne encephalitis virus (TBEV) in horses from Germany (2010–2020).</strong><br />
Tierarztl Prax (Ausg K). 2022;50(2):149. English. doi: 10.1055/s-0042-1744097.</p>
<div class="hr-thin"></div>
<p>Kuder H, Dikeson SK, Gailani D, Kehl A, Brooks MB, Müller E, Giger U.<br />
<strong>A missense variant in F11 gene causes coagulation factor XI deficiency in Maine Coon cats with increased bleeding tendency.</strong><br />
Tierarztl Prax (Ausg K).2022;50(1):64-5. English. doi: 10.1055/s-0041-1741156.</p>
<div class="hr-thin"></div>
<p>Kuder H, Dickeson SK, Brooks MB, Kehl A, Müller E, Gailani D, Giger U. A Common<br />
<strong>Missense Variant Causing Factor XI Deficiency and Increased Bleeding Tendency in Maine Coon Cats.</strong><br />
Genes (Basel). 2022;13(5):792. doi: 10.3390/genes13050792.</p>
<div class="hr-thin"></div>
<p>Ottka C, Puurunen J, Müller E, Weber C, Klein R, Lohi H.<br />
<strong>Metabolic changes associated with two endocrine abnormalities in dogs: elevated fructosamine and low thyroxine.</strong><br />
Metabolomics. 2022;18(8):58. doi: 10.1007/s11306-022-01917-4.</p>
<div class="hr-thin"></div>
<p>Jäger K, Cerezo-Echevarria A, Pohl A, Straub J, Fischer D, Aupperle-Lellbach H.<br />
<strong>Histopathological Findings in the Cardiovascular System of Psittacidae in Routine Diagnostics.</strong><br />
Vet Clin North Am Exot Anim Pract. 2022;25(2):453-67. doi: 10.1016/j.cvex.2022.01.009.</p>
<div class="hr-thin"></div>
<p>Könenkamp L, Ziegler U, Naucke T, Groschup MH, Steffen I.<br />
<strong>Antibody ratios against NS1 antigens of tick-borne encephalitis and West Nile viruses support differential flavivirus serology in dogs.</strong><br />
Transbound Emerg Dis. 2022;69(5):e2789-e2799. doi: 10.1111/tbed.14630.</p>
<div class="hr-thin"></div>
<p>Maluta A, Zając M, Krajewska-Wędzina M, Wasyl D, Heckers K, Didkowska A, Anusz K.<br />
<strong>Mixed Infection of </strong><em>Mycobacterium szulgai</em><strong>, </strong><em>M. lentiflavum</em><strong>, and Gram-Negative Bacteria as a Cause of Death in a Brown Caiman </strong><em>Caiman crocodylus</em><strong>: A Case Report.</strong><br />
Vet Sci. 2022;9(3):133. doi: 10.3390/vetsci9030133.</p>
<div class="hr-thin"></div>
<p>Helm CS, Weingart C, Ramünke S, Schäfer I, Müller E, von Samson-Himmelstjerna G, Kohn B, Krücken J.<br />
<strong>High genetic diversity of Babesia canis (Piana &amp; Galli-Valerio, 1895) in a recent local outbreak in Berlin/ Brandenburg, Germany.</strong><br />
Transbound Emerg Dis. 2022;69(5):e3336-e3345. doi: 10.1111/tbed.14617.</p>
<div class="hr-thin"></div>
<p>Cerezo A, Grassinger JM, Beitzinger C, Klopfleisch R, Aupperle-Lellbach H.<br />
<strong>Evaluating the Histological Grade of Digital Squamous Cell Carcinomas in Dogs with Dark and Light Haircoat—A Comparative Study of the Invasive Front and TumoUr Cell Budding Systems.</strong><br />
J Comp Path. 2022;191:10. doi: 10.1016/j.jcpa.2021.11.021.</p>
<div class="hr-thin"></div>
<p>Turchetto S, Törner, Grassinger JM, Müller T, Floren A, Aupperle-Lellbach H.<br />
<strong>Evaluation of the Occurrence of Spontaneous Tumours in Young Dogs.</strong><br />
J Comp Path. 2022;191:21. doi: 10.1016/j.jcpa.2021.11.049.</p>
<div class="hr-thin"></div>
<p>Flock U, Reese S, Otzdorff C, Klein R, Walter B.<br />
<strong>Anti-Müllerian hormone concentrations in queens throughout the estrous cycle.</strong><br />
Domest Anim Endocrinol. 2022;81:106749. doi: 10.1016/j.domaniend.2022.106749.</p>
<div class="hr-thin"></div>
<p>de Vries C, Grinwis GC, Staszyk C, Hendricks A, Christen M, Leeb T, Kehl A, Müller E, Booij-Vrieling HE.<br />
<strong>Dental-Skeletal-Retinal Anomaly – A New Autosomal Recessive Inherited Syndrome in Cane Corso Dogs.</strong><br />
J Comp Path. 2022;191:26. doi: 10.1016/j.jcpa.2021.11.059.</p>
<div class="hr-thin"></div>
<p>Schäfer I, Silaghi C, Fischer S, Marsboom C, Hendrickx G, Gehlen H, Müller E.<br />
<strong>Detection of Anaplasma phagocytophilum in horses from Germany by molecular and serological testing (2008-2021).</strong><br />
Vet Parasitol. 2022;312:109840. doi: 10.1016/j.vetpar.2022.109840.</p>
<div class="hr-thin"></div>
<p>Imbery CA, Dieterle F , Ottka D, Weber D, Schlotterbeck G, Müller E, Lohi H, Giger U.<br />
<strong>Metabolomic serum abnormalities in dogs with hepatopathies: Congenital portosystemic shunts versus high liver enzyme activities.</strong><br />
Tierarztl Prax (Ausg K). 2022;50(1):70. English. doi: 10.1055/s-0041-1741173.</p>
<div class="hr-thin"></div>

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		<title>2021 &#124; Publications English</title>
		<link>https://laboklin.com/en/2021-publications-english/</link>
		
		<dc:creator><![CDATA[Laboklin &#124; Bad Kissingen]]></dc:creator>
		<pubDate>Fri, 17 Dec 2021 13:57:16 +0000</pubDate>
				<category><![CDATA[2021]]></category>
		<category><![CDATA[Publications English]]></category>
		<guid isPermaLink="false">https://staging.laboklin.com/int/en/?p=1314174</guid>

					<description><![CDATA[- Cheilitis associated with a novel herpesvirus in two panther chameleons
- Detection of Testadenoviruses and Atadenoviruses in Tortoises and Turtles in Europe
- Diagnotics of infectious respiratory pathogens in reptiles
- Detection of Infectious Agents in Samples from Reptiles Presented at Veterinary Clinics in Poland
- A SINE Insertion in F8 Gene Leads to Severe Form of Hemophilia A in a Family of Rhodesian Ridgebacks.
...]]></description>
										<content:encoded><![CDATA[<div class="wpb-content-wrapper"><div class="vc_row wpb_row vc_row-fluid dt-default" style="margin-top: 0px;margin-bottom: 0px"><div class="wpb_column vc_column_container vc_col-sm-12"><div class="vc_column-inner"><div class="wpb_wrapper">
	<div class="wpb_text_column wpb_content_element " >
		<div class="wpb_wrapper">
			<blockquote>
<h4>Cheilitis associated with a novel herpesvirus in two panther chameleons (Furcifer pardalis)</h4>
</blockquote>
<p>Hellebuyk T, Couck L, Ducatelle R, Van den Broeck W, Marschang RE<br />
J. Comp. Path. 2021, Vol. 182, 58e66</p>
<p><a href="https://www.sciencedirect.com/science/article/abs/pii/S0021997520301626?via%3Dihub" target="_blank" rel="noopener">https://www.sciencedirect.com/science/article/abs/pii/S0021997520301626?via%3Dihub</a></p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
<blockquote>
<h4>Detection of Testadenoviruses and Atadenoviruses in Tortoises and Turtles in Europe</h4>
</blockquote>
<p>Ekaterina Salzmann, Elisabeth Müller, Rachel E. Marschang<br />
Journal of Zoo and Wildlife Medicine, 52(1)</p>
<p><a href="https://bioone.org/journals/Journal-of-Zoo-and-Wildlife-Medicine" target="_blank" rel="noopener">https://bioone.org/journals/Journal-of-Zoo-and-Wildlife-Medicine</a></p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
<blockquote>
<h4>Mass mortality of unknown etiology in alpine newts (Ichtyosaura alperstris veluchiensis) in an alpine lake in Greece</h4>
</blockquote>
<p>P.N. Azmanis, V. Schmidt, I. Sainis, R.E. Marschang, H. Papaioannou<br />
Journal of the Hellenic Veterinary Medical Society Vol. 72, 2021</p>
<p><a href="https://ejournals.epublishing.ekt.gr/index.php/jhvms/article/viewFile/26784/21600#page=101" target="_blank" rel="noopener">https://ejournals.epublishing.ekt.gr/index.php/jhvms/article/viewFile/26784/21600#page=101</a></p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
<blockquote>
<h4>Diagnotics of infectious respiratory pathogens in reptiles.</h4>
</blockquote>
<p>Marschang RE, Salzmann E, Pees M.<br />
Vet Clin Exot Anim 24</p>
<p><a href="https://authors.elsevier.com/a/1cxd93uzBB9NcA" target="_blank" rel="noopener">https://authors.elsevier.com/a/1cxd93uzBB9NcA</a></p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
<blockquote>
<h4>Detection of Infectious Agents in Samples from Reptiles Presented at Veterinary Clinics in Poland</h4>
</blockquote>
<p>Pasterny J, Skomorucha L, Stanicki K, Marschang RE<br />
Journal of Herpetological Medicine and Surgery (2021) 31 (1</p>
<p><a href="https://bioone.org/journals/journal-of-herpetological-medicine-and-surgery/" target="_blank" rel="noopener">https://bioone.org/journals/journal-of-herpetological-medicine-and-surgery/</a></p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
<blockquote>
<h4>A SINE Insertion in F8 Gene Leads to Severe Form of Hemophilia A in a Family of Rhodesian Ridgebacks</h4>
</blockquote>
<p>Alexandra Kehl, Anita Haug Haaland, Ines Langbein-Detsch, Elisabeth Mueller<br />
Genes2021,12,134</p>
<p><a href="https://www.proquest.com/openview/e97f0493af64384fd6c1c64969de6c81/1?pq-origsite=gscholar&amp;cbl=2032392" target="_blank" rel="noopener">https://www.proquest.com/openview/e97f0493af64384fd6c1c64969de6c81/1?pq-origsite=gscholar&amp;cbl=2032392</a></p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
<blockquote>
<h4>Evaluating the Histologic Grade of Digital Squamous Cell Carcinomas in Dogs with Dark and Light Haircoat—A Comparative Study of the Invasive Front and Tumor Cell Budding Systems</h4>
</blockquote>
<p>Argiñe Cerezo-Echevarria, Julia M. Grassinger, Christoph Beitzinger, Robert Klopfleisch, Heike Aupperle-Lellbach<br />
Vet. Sci. 2021, 8, 3</p>
<p><a href="https://www.proquest.com/openview/126ccfba44a92310ad38f68ba3e83943/1?pq-origsite=gscholar&amp;cbl=2059540" target="_blank" rel="noopener">https://www.proquest.com/openview/126ccfba44a92310ad38f68ba3e83943/1?pq-origsite=gscholar&amp;cbl=2059540</a></p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
<h4>A novel iguanid herpesvirus detected in asymptomatic green iguanas (Iguana iguana) in Poland</h4>
<p>Rachel E.Marschang, PD Dr med vet,Dipl ECZM Herp, Joanna Pasterny,DVM,Jakub Seń,DVM, Łukasz Skomorucha, DVM, and Kacper Stanicki, DVM<br />
Journal of Zoo and Wildlife Medicine 52(2):</p>
<p><a href="https://bioone.org/journals/Journal-of-Zoo-and-Wildlife-Medicine" target="_blank" rel="noopener">https://bioone.org/journals/Journal-of-Zoo-and-Wildlife-Medicine</a> on 28 Jun 2021</p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
<blockquote>
<h4>Letter regarding &#8220;ACVIM consensus statement on pancreatitis in cats&#8221;</h4>
</blockquote>
<p>Katrin Törner, Heike Aupperle-Lellbach<br />
J Vet Intern Med. 2021 July-Aug; 35(4)</p>
<p><a href="https://onlinelibrary.wiley.com/doi/full/10.1111/jvim.16168" target="_blank" rel="noopener">https://onlinelibrary.wiley.com/doi/full/10.1111/jvim.16168</a></p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
<blockquote>
<h4>Effects of the antivirals lysine and lactoferrin on testudinid herpesviruses and a ranavirus in cell culture.</h4>
</blockquote>
<p>Marschang RE, Müller E.<br />
J Herpetol Med Surg. 31(2)</p>
<p><a href="https://meridian.allenpress.com/jhms/article-abstract/31/2/151/468471/Effects-of-the-Antivirals-Lysine-and-Lactoferrin" target="_blank" rel="noopener">https://meridian.allenpress.com/jhms/article-abstract/31/2/151/468471/Effects-of-the-Antivirals-Lysine-and-Lactoferrin</a></p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
<blockquote>
<h4>Digital Lesions in Dogs: A Statistical Breed Analysis of 2912 Cases</h4>
</blockquote>
<p>Julia Maria Grassinger, Andreas Floren, Tobias Müller, Argiñe Cerezo-Echevarria, Christoph Beitzinger, David Conrad, Katrin Törner, Marlies Staudacher, Heike Aupperle-Lellbach<br />
Vet. Sci. 2021, 8, 136.</p>
<p><a href="https://www.mdpi.com/2306-7381/8/7" target="_blank" rel="noopener">https://www.mdpi.com/2306-7381/8/7</a></p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
<blockquote>
<h4>Serum anti-Müllerian hormone concentration as a diagnostic tool to identify testicular tissue in canine disorders of sexual development</h4>
</blockquote>
<p>B. Walter, U. Flock, C. Leykam, C. Otzdorffa, K. Simmet, W. Hecht, L. Kempker, H. Aupperle-Lellbach, S. Reese<br />
Domestic Animal Endocrinology 78 (2022) 106654</p>
<p><a href="https://www.journals.elsevier.com/domestic-animal-endocrinology" target="_blank" rel="noopener">https://www.journals.elsevier.com/domestic-animal-endocrinology</a></p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
<blockquote>
<h4>First Description of Sarcoptic Mange in a Free-Ranging European Wildcat (Felis silvestris silvestris) from Spain</h4>
</blockquote>
<p>Fernando Nájera ,Elena Crespo, Amalia García-Talens, Rebeca Grande-Gómez, Francisco Javier Herrera-Sánchez ,Michaela Gentil ,Carmen Cortés-García ,Elisabeth Müller ,Rafael Calero-Bernal, andLuis Revuelta<br />
Animals 2021, 11(9), 2494</p>
<p><a href="https://www.mdpi.com/2076-2615/11/9/2494" target="_blank" rel="noopener">https://www.mdpi.com/2076-2615/11/9/2494</a></p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
<blockquote>
<h4>Two novel adenoviruses in free-living british lizards</h4>
</blockquote>
<p>Donald HCF, Foster J, Wilkinson JW, Hill P, Barber M, Mee g, Edgar P, Marschang RE, Sainsbury AW<br />
EcoHealth (2021)</p>
<p><a href="https://link.springer.com/article/10.1007/s10393-021-01560-w" target="_blank" rel="noopener">https://link.springer.com/article/10.1007/s10393-021-01560-w</a></p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
<blockquote>
<h4>Herpesviruses in captive chelonians in Europe between 2016 and 2020</h4>
</blockquote>
<p>Leineweber C, Müller E, Marschang RE<br />
Front.Vet.Sci.8:733299 (13 October 2021)</p>
<p><a href="https://www.frontiersin.org/articles/10.3389/fvets.2021.733299/full" target="_blank" rel="noopener">https://www.frontiersin.org/articles/10.3389/fvets.2021.733299/full</a></p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
<blockquote>
<h4>Anaplasma phagocytophilum in domestic cats from Germany, Austria and Switzerland and clinical/laboratory findings in 18 PCR-positive cats (2008–2020)</h4>
</blockquote>
<p>Ingo Schäfer, Barbara Kohn, Elisabeth Müller<br />
Journal of Feline Medicine and Surgery 1–8</p>
<p><a href="https://journals.sagepub.com/doi/abs/10.1177/1098612X211017459" target="_blank" rel="noopener">https://journals.sagepub.com/doi/abs/10.1177/1098612X211017459</a></p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
<blockquote>
<h4>Retrospective evaluation of vector-borne pathogens in cats living in Germany (2012–2020)</h4>
</blockquote>
<p>Ingo Schäfer, Barbara Kohn, Maria Volkmann, Elisabeth Müller<br />
Parasites Vectors 14, 123 (2021).</p>
<p><a href="https://link.springer.com/article/10.1186/s13071-021-04628-2" target="_blank" rel="noopener">https://link.springer.com/article/10.1186/s13071-021-04628-2</a></p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
<blockquote>
<h4>Comparative study of immunohematological tests with canine blood samples submitted for a direct antiglobulin (Coombs’) test</h4>
</blockquote>
<p>Nadine Idalan, Johanna O. Zeitz, Corinna N. Weber, Elisabeth Müller, Urs Giger<br />
Canine Medicine and Genetics volume 8, Article number: 10 (2021)</p>
<p><a href="https://cgejournal.biomedcentral.com/articles/10.1186/s40575-021-00107-0" target="_blank" rel="noopener">https://cgejournal.biomedcentral.com/articles/10.1186/s40575-021-00107-0</a></p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
<blockquote>
<h4>Age and hydration of competing horses influence the outcome of elite 160 km endurance rides</h4>
</blockquote>
<p>Lena Bollinger, Alexander Bartel, Alina Küper, Corinna Weber, Heidrun Gehlen<br />
Front. Vet. Sci., 14 May 2021</p>
<p><a href="https://internal-journal.frontiersin.org/articles/10.3389/fvets.2021.668650/full" target="_blank" rel="noopener">https://internal-journal.frontiersin.org/articles/10.3389/fvets.2021.668650/full</a></p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
<blockquote>
<h4>Efficacy of Nx4 to Reduce Plasma Cortisol and Gastrin Levels in Norwegian Sled Dogs During an Exercise Induced Stress Response: A Prospective, Randomized, Double Blinded, Placebo-Controlled Cohort Study</h4>
</blockquote>
<p>Alexandra Keller, Jana Conradi, Corinna Weber, Klaus Failing, Melanie Wergin<br />
Front. Vet. Sci., 26 October 2021</p>
<p><a href="https://www.frontiersin.org/articles/10.3389/fvets.2021.741459/full" target="_blank" rel="noopener">https://www.frontiersin.org/articles/10.3389/fvets.2021.741459/full</a></p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
<blockquote>
<h4>Evaluation of Different Blood Parameters From Endurance Horses Competing at 160 km</h4>
</blockquote>
<p>Antonia Ertelt, Roswitha Merle, Friederike Stumpff, Lena Bollinger, Sarah Liertz, Corinna Weber, Heidrun Gehlen<br />
Journal of Equine Veterinary Science 104 (2021)</p>
<p><a href="https://www.sciencedirect.com/science/article/abs/pii/S0737080621003178" target="_blank" rel="noopener">https://www.sciencedirect.com/science/article/abs/pii/S0737080621003178</a></p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
<blockquote>
<h4>Serum NMR metabolomics uncovers multiple metabolic changes in phenobarbital-treated dogs</h4>
</blockquote>
<p>Claudia Ottka, Corinna Weber,  Elisabeth Müller, Hannes Lohi<br />
Metabolomics volume 17, Article number: 54 (2021)</p>
<p><a href="https://link.springer.com/article/10.1007/s11306-021-01803-5" target="_blank" rel="noopener">https://link.springer.com/article/10.1007/s11306-021-01803-5</a></p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
<blockquote>
<h4>Kinetics of serum amyloid A during the treatment period of foals with pneumonia</h4>
</blockquote>
<p>Lankenfeld Anna; Weber Corina; Rohn Karl; Venner Monica<br />
Pferdeheilkunde, Bd. 37, H. 2 (2021)</p>
<p><a href="https://www.pferdeheilkunde.de/10.21836/PEM20210204" target="_blank" rel="noopener">https://www.pferdeheilkunde.de/10.21836/PEM20210204</a></p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
<blockquote>
<h4>Deletion of the SELENOP gene leads to CNS atrophy with cerebellar ataxia in dogs</h4>
</blockquote>
<p>Matthias Christen, Sandra Högler, Miriam Kleiter, Michael Leschnik, Corinna Weber, Denise Thaller, Vidhya Jagannathan, Tosso Leeb<br />
PLOS Genetics 17(8):e1009716.</p>
<p><a href="https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1009716" target="_blank" rel="noopener">https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1009716</a></p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
<blockquote>
<h4>Signalment and Clinical Data of Cats with Exocrine Pancreatic Insufficiency Diagnosed Using Feline Trypsin-like Immunoreactivity in Routine Diagnostics</h4>
</blockquote>
<p>Katrin Törner, Julia Maria Grassinger, Corinna N. Weber, Heike Aupperle-Lellbach, Argine Cerezo-Echevarria, Elisabeth Müller<br />
Vet. Sci. 2021, 8(8), 155</p>
<p><a href="https://www.mdpi.com/2306-7381/8/8/155" target="_blank" rel="noopener">https://www.mdpi.com/2306-7381/8/8/155</a></p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
<blockquote>
<h4>The use of filtered plasma to determine passive immunization by colostrum uptake in neonatal calves.</h4>
</blockquote>
<p>Franziska Sutter, Stefan Borchardt, Elke Rauch, Michael Erhard, Ron Sargent, Corinna Weber, Wolfgang Heuwieser<br />
Der Praktische Tierarzt 102(3)</p>
<p><a href="https://www.vetline.de/nutzung-von-gefiltertem-plasma-zur-bestimmung-der-passiven-immunisierung-durch-kolostrum-aufnahme" target="_blank" rel="noopener">https://www.vetline.de/nutzung-von-gefiltertem-plasma-zur-bestimmung-der-passiven-immunisierung-durch-kolostrum-aufnahme</a></p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
<blockquote>
<h4>Randomized clinical trial to evaluate the effects of a prepartum cholecalciferol injection on postpartum serum calcium dynamics and health and performance in early-lactation multiparous dairy cows</h4>
</blockquote>
<p>Peter Venjakob, Lars Bauerfeind, Rudolf Staufenbiel, Mirja Wilkens, Corinna Weber, Wolfgang Heuwieser, Stefan Borchardt<br />
J Dairy Sci. 2021 Nov 18</p>
<p><a href="https://www.sciencedirect.com/science/article/abs/pii/S0022030221010316" target="_blank" rel="noopener">https://www.sciencedirect.com/science/article/abs/pii/S0022030221010316</a></p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
<blockquote>
<h4>Progesterone concentrations during canine pregnancy</h4>
</blockquote>
<p>Janna Hinderer, Julia Luedeke, Lisa Riege, Peggy Haimerl, Alexander Bartel, Barbara Kohn, Corinna Weber, Elisabeth Müller, Sebastian Arlt<br />
Animals 2021, 11, 3369.</p>
<p><a href="https://www.mdpi.com/2076-2615/11/12/3369" target="_blank" rel="noopener">https://www.mdpi.com/2076-2615/11/12/3369</a></p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
<blockquote>
<h4>Bridging the Species Gap: Morphological and Molecular Comparison of Feline and Human Intestinal Carcinomas</h4>
</blockquote>
<p>Tanja Groll, Franziska Schopf, Daniela Denk, Carolin Mogler, Ulrike Schwittlick, Heike Aupperle-Lellbach, Sabrina Rim Jahan Sarker, Nicole Pfarr, Wilko Weichert, Kaspar Matiasek, Moritz Jesinghaus, Katja Steiger<br />
Cancers 2021, 13(23), 5941</p>
<p><a href="https://www.mdpi.com/2072-6694/13/23/5941" target="_blank" rel="noopener">https://www.mdpi.com/2072-6694/13/23/5941</a></p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
<blockquote>
<h4>Anti-Müllerian hormone, testosterone, and insulin-like peptide 3 as biomarkers of Sertoli and Leydig cell function during deslorelin-induced testicular downregulation in the dog</h4>
</blockquote>
<p>Orsolya Balogh, Bence Somoskői, Eszter Kollár, Mariusz P Kowalewski, Aykut Gram, Iris M Reichler, Ruth Klein, Noritoshi Kawate, László Mester, Beate Walter, Linda Müller<br />
Theriogenology, 2021 Nov;175:</p>
<p><a href="https://www.sciencedirect.com/science/article/pii/S0093691X21002831" target="_blank" rel="noopener">https://www.sciencedirect.com/science/article/pii/S0093691X21002831</a></p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
<blockquote>
<h4>Correlation of Histopathological Changes in the Left Atrium and Left Atrial Appendage with the Degree of Dilation in Cats</h4>
</blockquote>
<p>Julia M Grassinger, Manfred Henrich, Argine C Echevarría, Imke März, Estelle Henrich, Alexander Bartel, Matthias Schneider, Heike Aupperle-Lellbach<br />
Journal of Comparative Pathology, Volume 189, November 2021</p>
<p><a href="https://www.sciencedirect.com/science/article/abs/pii/S0021997521001158?via%3Dihub" target="_blank" rel="noopener">https://www.sciencedirect.com/science/article/abs/pii/S0021997521001158?via%3Dihub</a></p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
<blockquote>
<h4>Tumours in 177 pet hamsters</h4>
</blockquote>
<p>Nancy Rother, Christof A. Bertram, Robert Klopfleisch, Marco Fragoso-Garcia, Wolf V. Bomhard, Claudia Schandelmaier, Kerstin Müller<br />
Vet Rec. 2021;e14</p>
<p><a href="https://bvajournals.onlinelibrary.wiley.com/doi/full/10.1002/vetr.14" target="_blank" rel="noopener">https://bvajournals.onlinelibrary.wiley.com/doi/full/10.1002/vetr.14</a></p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
<blockquote>
<h4>MIA3 Splice Defect in Cane Corso Dogs with Dental-Skeletal-Retinal Anomaly (DSRA)</h4>
</blockquote>
<p>Matthias Christen, Henriëtte Booij-Vrieling, Jelena Oksa-Minalto, Cynthia de Vries, Alexandra Kehl, Vidhya Jagannathan, Tosso Leeb<br />
Genes 2021, 12, 1497</p>
<p><a href="https://www.mdpi.com/2073-4425/12/10/1497" target="_blank" rel="noopener">https://www.mdpi.com/2073-4425/12/10/1497</a></p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
<blockquote>
<h4>SARS-CoV-2–Specific Antibodies in Domestic Cats during First COVID-19 Wave, Europe</h4>
</blockquote>
<p>Schulz C., Martina B., Mirolo M., Müller E., Klein R., Volk H., Egberink H., Gonzalez-Hernandez M., Kaiser F., von Köckritz-Blickwede M., Osterhaus A.<br />
Volume 27, Number 12—December 2021</p>
<p><a href="https://wwwnc.cdc.gov/eid/article/27/12/21-1252_article" target="_blank" rel="noopener">https://wwwnc.cdc.gov/eid/article/27/12/21-1252_article</a></p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
<blockquote>
<h4>A Single Base Insertion in F9 Causing Hemophilia B in a Family of Newfoundland–Parti Standard Poodle Hybrid Dogs</h4>
</blockquote>
<p>Kuder H., Sandzhieva-Vuzzo L., Kehl A., Rappaport J. M., Mueller E., Giger U.<br />
Genes 2021, 12(10), 1491</p>
<p><a href="https://www.mdpi.com/2073-4425/12/10/1491" target="_blank" rel="noopener">https://www.mdpi.com/2073-4425/12/10/1491</a></p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
<blockquote>
<h4>NHLRC1 homozygous dodecamer expansion in a Newfoundland dog with Lafora disease</h4>
</blockquote>
<p>Mari L., Comero G., Müller E., Kuehnlein P., Kehl A.<br />
JSAP Volume62, Issue11, November 2021</p>
<p><a href="https://onlinelibrary.wiley.com/doi/abs/10.1111/jsap.13396" target="_blank" rel="noopener">https://onlinelibrary.wiley.com/doi/abs/10.1111/jsap.13396</a></p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
<blockquote>
<h4>A testudinid herpesvirus 1 (TeHV1)-associated disease outbreak in a group of Horsfield’s tortoises (Testudo horsfieldii)</h4>
</blockquote>
<p>Lisa Schüler, Pierre Picquet, Christoph Leineweber, Janosch Dietz, Elisabeth Müller, Rachel E. Marschang<br />
Tierarztl Prax Ausg K Kleintiere Heimtiere 2021; 49(06)</p>
<p><a href="https://www.thieme-connect.de/products/ejournals/abstract/10.1055/a-1666-8378" target="_blank" rel="noopener">https://www.thieme-connect.de/products/ejournals/abstract/10.1055/a-1666-8378</a></p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
<blockquote>
<h4>BRAF mutation status and its prognostic significance in 79 canine urothelial carcinomas: A retrospective study (2006–2019)</h4>
</blockquote>
<p>Julia Gedon, Alexandra Kehl, Heike Aupperle-Lellbach, Wolf von Bomhard,Jarno M. Schmidt<br />
Veterinary and Comparative Oncology, 08 Dec 2021,</p>
<p><a href="https://onlinelibrary.wiley.com/doi/abs/10.1111/vco.12790" target="_blank" rel="noopener">https://onlinelibrary.wiley.com/doi/abs/10.1111/vco.12790</a></p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
<blockquote>
<h4>Serum anti-Müllerian hormone concentration as a diagnostic tool to identify testicular tissue in canine disorders of sexual development</h4>
</blockquote>
<p>B.Walter, U.Flock, C.Leykam, C.Otzdorff, K.Simmet, W.Hecht, L.Kempker, H.Aupperle-Lellbach, S.Reesee<br />
Domestic Animal Endocrinology, Volume 78, January 2022, 106654</p>
<p><a href="https://www.sciencedirect.com/science/article/abs/pii/S0739724021000515?via%3Dihub" target="_blank" rel="noopener">https://www.sciencedirect.com/science/article/abs/pii/S0739724021000515?via%3Dihub</a></p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
<blockquote>
<h4>Molecular detection of Hepatozoon species infections in domestic cats living in Germany</h4>
</blockquote>
<p>Ingo Schäfer, Barbara Kohn, Ard M Nijhof, Elisabeth Müller<br />
Journal of Feline Medicine &amp; Surgery · November 2021</p>
<p><a href="https://journals.sagepub.com/doi/abs/10.1177/1098612X211055680" target="_blank" rel="noopener">https://journals.sagepub.com/doi/abs/10.1177/1098612X211055680</a></p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
<blockquote>
<h4>Humoral responses to SARS‑CoV‑2 by healthy and sick dogs during the COVID‑19 pandemic in Spain</h4>
</blockquote>
<p>Ana Judith Perisé‑Barrios, Beatriz Davinia Tomeo‑Martín, Pablo Gómez‑Ochoa, Pablo Delgado‑Bonet, Pedro Plaza, Paula Palau‑Concejo, Jorge González, Gustavo Ortiz‑Díez, Antonio Meléndez‑Lazo, Michaela Gentil, Javier García‑Castro, Alicia Barbero‑Fernández<br />
Veterinary Research volume 52, Article number: 22 (2021)</p>
<p><a href="https://veterinaryresearch.biomedcentral.com/articles/10.1186/s13567-021-00897-y" target="_blank" rel="noopener">https://veterinaryresearch.biomedcentral.com/articles/10.1186/s13567-021-00897-y</a></p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
<blockquote>
<h4>Plasma capillary zone electrophoresis and plasma chemistry analytes in tortoises (Testudo hermanni, Testudo graeca) and turtles (Trachemys scripta elegans, Graptemys spp.) in fall.</h4>
</blockquote>
<p>Leineweber C, Stöhr AC, Öfner S, Mathes K, Marschang RE.<br />
J Zoo Wildl Med. 2021 Jan;51(4)</p>
<p><a href="https://bioone.org/journals/journal-of-zoo-and-wildlife-medicine/volume-51/issue-4/2019-0091/PLASMA-CAPILLARY-ZONE-ELECTROPHORESIS-AND-PLASMA-CHEMISTRY-ANALYTES-IN-TORTOISES/10.1638/2019-0091.short" target="_blank" rel="noopener">https://bioone.org/journals/journal-of-zoo-and-wildlife-medicine/volume-51/issue-4/2019-0091/PLASMA-CAPILLARY-ZONE-ELECTROPHORESIS-AND-PLASMA-CHEMISTRY-ANALYTES-IN-TORTOISES/10.1638/2019-0091.short</a></p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
<blockquote>
<h4>Clinical chemistry, vitamin, electrophoresis, and hematologic analytes of black-headed ibis (threskiornis melanocephalus)</h4>
</blockquote>
<p>Leineweber C., Beckmann J., Westerhüs U., Müller E., Fischer D.<br />
J. of Zoo and Wildlife Medicine, 51(4)</p>
<p><a href="https://bioone.org/journals/journal-of-zoo-and-wildlife-medicine/volume-51/issue-4/2020-0030/CLINICAL-CHEMISTRY-VITAMIN-ELECTROPHORESIS-AND-HEMATOLOGIC-ANALYTES-OF-BLACK-HEADED/10.1638/2020-0030.short" target="_blank" rel="noopener">https://bioone.org/journals/journal-of-zoo-and-wildlife-medicine/volume-51/issue-4/2020-0030/CLINICAL-CHEMISTRY-VITAMIN-ELECTROPHORESIS-AND-HEMATOLOGIC-ANALYTES-OF-BLACK-HEADED/10.1638/2020-0030.short</a></p>

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		<title>2020 &#124; Publications English</title>
		<link>https://laboklin.com/en/publikationen-englisch-2020/</link>
		
		<dc:creator><![CDATA[Laboklin &#124; Bad Kissingen]]></dc:creator>
		<pubDate>Fri, 18 Dec 2020 09:58:36 +0000</pubDate>
				<category><![CDATA[2020]]></category>
		<category><![CDATA[Publications English]]></category>
		<guid isPermaLink="false">https://staging.laboklin.com/int/en/?p=1306386</guid>

					<description><![CDATA[- Veterinary Diagnostic Approach of Common Virus Diseases in Adult Honeybees
- Overt Infection with Chronic Bee Paralysis Virus (CBPV) in Two Honey Bee Colonies
- Histopathology and feline pancreatic lipase immunoreactivity in inflammatory...
- Histopathological findings and canine pancreatic lipase immunoreactivity in normal dogs...
- A comparison of thyroid hormone levels and plasma capillary zone electrophoresis in red‐eared sliders...
...]]></description>
										<content:encoded><![CDATA[<div class="wpb-content-wrapper"><div class="vc_row wpb_row vc_row-fluid dt-default" style="margin-top: 0px;margin-bottom: 0px"><div class="wpb_column vc_column_container vc_col-sm-12"><div class="vc_column-inner"><div class="wpb_wrapper">
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<blockquote>
<h4 class="csc-firstHeader">Veterinary Diagnostic Approach of Common Virus Diseases in Adult Honeybees</h4>
</blockquote>
<p class="bodytext">by Julia Dittes, Heike Aupperle-Lellbach, Marc O. Schäfer, Christoph K. W. Mülling and Ilka U. Emmerich</p>
<p><a href="https://www.mdpi.com/2306-7381/7/4/159" target="_blank" rel="noopener">https://www.mdpi.com/2306-7381/7/4/159</a></p>
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<p>&nbsp;</p>
</div>
<div id="c8026" class="csc-frame csc-frame-rulerAfter csc-space-after-25">
<blockquote>
<h4>Overt Infection with Chronic Bee Paralysis Virus (CBPV) in Two Honey Bee Colonies</h4>
</blockquote>
<p class="bodytext">by Julia Dittes, Marc O. Schäfer, Heike Aupperle-Lellbach, Christoph K. W. Mülling and Ilka U. Emmerich</p>
<p class="bodytext"><a href="https://www.mdpi.com/2306-7381/7/3/142" target="_blank" rel="noopener">https://www.mdpi.com/2306-7381/7/3/142</a></p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
</div>
<div id="c7603" class="csc-frame csc-frame-rulerAfter csc-space-after-25">
<blockquote>
<h4>Histopathology and feline pancreatic lipase immunoreactivity in inflammatory, hyperplastic and neoplastic pancreatic diseases in cats</h4>
</blockquote>
<p class="bodytext" align="justify">Autor: Törner K, Staudacher M, Tress U, Weber CN, Stadler C, Grassinger JM, Müller E, Aupperle-Lellbach H</p>
<p class="bodytext" align="justify">Quelle: <i>Journal of comparative pathology </i>2020. 174: 63–72.</p>
<p class="bodytext" align="justify"><a href="https://doi.org/10.1016/j.jcpa.2019.10.195" target="_blank" rel="noopener">doi.org/10.1016/j.jcpa.2019.10.195</a></p>
<p class="bodytext" align="justify"><b>Abstract:</b></p>
<p class="bodytext" align="justify">The most common pancreatic diseases in cats are pancreatitis and exocrine pancreatic insufficiency (EPI). Non-invasive methods, such as serological quantification of feline pancreatic lipase immunoreactivity (fPLI), are often used in the diagnosis of pancreatitis. Previous studies have compared fPLI concentrations with histopathology, considered to be the gold standard for diagnosis of feline pancreatitis. However, fPLI concentrations in cats suffering from pancreatic tumours were rarely described. The aim of the present study was to determine the sensitivity and specificity of an in-house enzyme-linked immunosorbent assay (ELISA) for the quantification of fPLI in serum samples based on histopathological findings in cats diagnosed with various pancreatic diseases.</p>
<p class="bodytext" align="justify">Pancreatic biopsy samples from 80 cats were included. Five groups were defined on the basis of pancreatic histopathology: group 1, normal pancreas; group 2, nodular hyperplasia; group 3, mild pancreatitis; group 4, marked (moderate/severe) pancreatitis; and group 5, pancreatic neoplasia. Serum samples from all cats were tested by fPLI ELISA (&lt;3.6 μg/l normal, 3.6-5.3 μg/l questionable, &gt;5.3 μg/l pancreatitis).</p>
<p class="bodytext" align="justify">In group 1 (n = 19), serum fPLI values were within the reference interval in 74% of cases and in group 2 (n = 9) in 78%. Cats with mild pancreatitis (n = 23), marked pancreatitis (n = 11) and pancreatic neoplasms (n = 18) had significantly increased fPLI concentrations compared with group 1 (P = 0.004/0.001/≤0.0001). Cats with nodular hyperplasia had significantly lower fPLI values than cats with marked pancreatitis (P = 0.048) or tumours (P = 0.002). Serum fPLI concentrations in group 3 were &lt;3.6 μg/l (n = 6), 3.6-5.3 μg/l (n = 4) and &gt;5.3 μg/l (n = 13). Calculated test sensitivity for mild pancreatitis was fPLI &gt;3.5 μg/l: 73.9% and fPLI &gt;5.3 μg/l: 56.5%. In group 4 (n = 11), seven of nine cats (77.8%) with marked purulent pancreatitis had elevated fPLI. In group 4, a sensitivity of 81.8% was detected for fPLI &gt;3.5 μg/l and 63.6% for fPLI &gt;5.3 μg/l. Two cats with marked non-purulent pancreatitis had elevated fPLI, while two cats with marked purulent pancreatitis had normal fPLI values (&lt;3.6 μg/l). In group 5, one cat with pancreatic adenoma and one with pancreatic acinar carcinoma had normal fPLI concentrations. The other cats with pancreatic adenoma (solid, n = 1; cystic, n = 4) or carcinoma (solid, n = 9; cystic, n = 2) had elevated or high fPLI values (4.1 to &gt;40 μg/l, median 21.2 μg/l), probably caused by additional inflammation.</p>
<p class="bodytext" align="justify">The results of the present study confirm the importance of detailed histopathological characterization for the interpretation of clinical signs and fPLI values in feline pancreatitis. Primary pancreatic neoplasms may also lead to elevated fPLI concentrations as there is concurrent pancreatitis in most cases. However, severe pancreatic diseases, such as chronic non-purulent pancreatitis or tumours without inflammation, may result in normal fPLI values.</p>
<p align="justify">
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<p align="justify">
</div>
<div id="c7604" class="csc-frame csc-frame-rulerAfter csc-space-after-25">
<blockquote>
<h4>Histopathological findings and canine pancreatic lipase immunoreactivity in normal dogs and dogs with inflammatory and neoplastic diseases of the pancreas</h4>
</blockquote>
<p class="bodytext" align="justify">Autor: Aupperle-Lellbach H, Törner K, Staudacher M, Stadler C, Tress U, Grassinger JM, Müller E, Weber CN</p>
<p class="bodytext" align="justify">Quelle: <i>Journal of Veterinary Internal Medicine </i>2020. 34<i>: </i>1127–1134.</p>
<p class="bodytext" align="justify">OPEN ACCESS: <a href="https://doi.org/10.1111/jvim.15779" target="_blank" rel="noopener">doi.org/10.1111/jvim.15779</a></p>
<p class="bodytext" align="justify"><b>Abstract:</b></p>
<p class="bodytext" align="justify">Background: Diagnosis of pancreatic diseases in dogs is still challenging because of variable clinical signs, which do not always correspond with clinical pathology and histopathological findings.</p>
<p class="bodytext" align="justify">Objectives: To characterize inflammatory and neoplastic pancreatic diseases of dogs and to correlate these findings with clinical findings and canine pancreatic lipase immunoreactivity (cPLI) results.</p>
<p class="bodytext" align="justify">Animals: Tissue specimens and corresponding blood samples from 72 dogs submitted for routine diagnostic testing.</p>
<p class="bodytext" align="justify">Methods: Four groups were defined histologically: (1) normal pancreas (n = 40), (2) mild pancreatitis (n = 8), (3) moderate or severe pancreatitis (acute, n = 11; chronic, n = 1), and (4) pancreatic neoplasms (n = 12). An in-house cPLI ELISA (&lt;180 μg/L, normal; &gt;310 μg/L, pancreatitis) was performed.</p>
<p class="bodytext" align="justify">Results: In dogs with normal pancreas, 92.5% of serum cPLI results were within the reference range and significantly lower than in dogs with mild acute pancreatitis, moderate or severe acute pancreatitis and pancreatic tumors. In dogs with moderate or severe acute pancreatitis, cPLI sensitivity was 90.9% (95% confidence interval [CI], 58.7%-99.8%). Most dogs (9/12) with pancreatic tumors (group 4) had additional pancreatic inflammation and cPLI results were increased in 10 dogs.</p>
<p class="bodytext" align="justify">Conclusions and clinical importance: High cPLI indicates serious acute pancreatitis but underlying pancreatic neoplasms should also be taken into consideration. This study confirms the relevance of histopathology in the diagnostic evaluation of pancreatic diseases.</p>
<p align="justify">
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<p align="justify">
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<div id="c7600" class="csc-frame csc-frame-rulerAfter csc-space-after-25">
<blockquote>
<h4>A comparison of thyroid hormone levels and plasma capillary zone electrophoresis in red‐eared sliders (Trachemys script a elegans ) and map turtles (Graptemys spp.) depending on season and sex</h4>
</blockquote>
<p class="bodytext">Autor: Christoph Leineweber, Sabine Öfner, Anke C. Stöhr, Rachel E. Marschang, Karina Mathes</p>
<p class="bodytext"><a href="https://onlinelibrary.wiley.com/doi/full/10.1111/vcp.12838" target="_blank" rel="noopener">https://onlinelibrary.wiley.com/doi/full/10.1111/vcp.12838</a></p>
<p class="bodytext">
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</div>
<div id="c7601" class="csc-frame csc-frame-rulerAfter csc-space-after-25">
<blockquote>
<h4>Clinical and pathological data of 17 non-epithelial pancreatic tumors in cats</h4>
</blockquote>
<p class="bodytext" align="justify">Autor: Törner K, Staudacher M, Steiger K, Aupperle-Lellbach H</p>
<p class="bodytext" align="justify">Quelle: <i>Veterinary Sciences</i> 2020. 7: 55</p>
<p class="bodytext" align="justify">OPEN ACCESS: <a href="https://doi.org/10.3390/vetsci7020055" target="_blank" rel="noopener">doi.org/10.3390/vetsci7020055</a></p>
<p class="bodytext" align="justify"><b>Abstract:</b></p>
<p class="bodytext" align="justify">Tumors of mesenchymal origin are rarely reported in the pancreas. Therefore, this study characterized 17 feline non-epithelial pancreatic tumors, including clinical data, histopathology, and immunohistochemistry.</p>
<p class="bodytext" align="justify">Seventeen feline pancreatic tissue samples were investigated histopathologically and immunohistochemically. Selected pancreatic and inflammatory serum parameters, e.g., feline pancreatic lipase immunoreactivity (fPLI), 1,2-o-dilauryl-rac-glycero-3-glutaric acid-(6&#8242;-methylresorufin) ester (DGGR) lipase and serum amyloid A (SAA), were recorded, when available.</p>
<p class="bodytext" align="justify">The neoplasms were characterized as round (n = 13) or spindle (n = 4) cell tumors. Round cell tumors included 12 lymphomas and one mast cell tumor in ectopic splenic tissue within the pancreas. Lymphomas were of T-cell (n = 9) or B-cell (n = 3) origin. These cats showed leukocytosis (3/3) and increased fPLI (5/5), DGGR lipase (3/5) and SAA (4/5) values. Spindle cell tumors included two hemangiosarcomas, one pleomorphic sarcoma and one fibrosarcoma. The cat with pleomorphic sarcoma showed increased SAA value. Overall survival time was two weeks to seven months.</p>
<p class="bodytext" align="justify">These are the first descriptions of a pancreatic pleomorphic sarcoma and a mast cell tumor in accessory spleens within feline pancreas. Although rare, pancreatic tumors should be considered in cats presenting with clinical signs and clinical pathology changes of pancreatitis. Only histopathology can certainly distinguish solitary pancreatitis from a neoplasm with inflammation.</p>
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		<title>2019 &#124; Publications English</title>
		<link>https://laboklin.com/en/2019-publications-english/</link>
		
		<dc:creator><![CDATA[Laboklin &#124; Bad Kissingen]]></dc:creator>
		<pubDate>Thu, 12 Dec 2019 07:24:59 +0000</pubDate>
				<category><![CDATA[2019]]></category>
		<category><![CDATA[Publications English]]></category>
		<guid isPermaLink="false">https://staging.laboklin.com/int/en/?p=4220</guid>

					<description><![CDATA[- Serum Vitamin A and E concentrations in dogs with pancreatitis
- Characterization of 22 canine pancreatic carcinomas and review of literature 
- Retrospective evaluation of vector-borne infections in dogs,,,
- Rabbit haemorrhagic disease virus type 2 in hares in England...
- Season and sex specific thyroid hormone levels in different European tortoise species 
...]]></description>
										<content:encoded><![CDATA[<div class="wpb-content-wrapper"><div class="vc_row wpb_row vc_row-fluid dt-default" style="margin-top: 0px;margin-bottom: 0px"><div class="wpb_column vc_column_container vc_col-sm-12"><div class="vc_column-inner"><div class="wpb_wrapper">
	<div class="wpb_text_column wpb_content_element " >
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			<blockquote>
<h4>Serum Vitamin A and E concentrations in dogs with pancreatitis</h4>
</blockquote>
<p>Autor: Weiß M, Törner K, Grassinger J, Müller E, Aupperle-Lellbach H</p>
<p>Quelle: ECVIM-CA, 19.–21.09.2019 in Mailand, Italien, Congress abstracts, 391.</p>
<p><strong>Abstract:</strong><br />
Acute and chronic pancreatitis in humans results in significantly lower levels of serum Vitamin A and Vitamin E due to antioxidative stress and as part of the inflammatory response. To our knowledge no studies about Vitamin A and E levels in serum of dogs with pancreatitis have been performed so far. The aim of this retrospective study was to evaluate the level of serum vitamin A and E from routine diagnostic left-over samples in dogs with pancreatitis compared to a control group of dogs with other diseases.<br />
40 dogs with pancreatitis were included in this study. These dogs all had serum pancreatic lipase concentrations &gt;600 μg/L and clinical symptoms of pancreatitis like vomiting, abdominal pain or inappetence and had received no medical treatment so far. Additionally, in 3 dogs pancreatitis was diagnosed by histology of pancreatic tissue biopsies. The 45 dogs of the control group had serum pancreatic lipase values &lt;40 μg/l and had clinical symptoms concurrent with other diseases than pancreatitis. Serum Vitamin A and E levels were measured by HPLC from cooled serum within 72 hours of sampling.<br />
Dogs with pancreatitis had significantly higher (P &lt; 0.001) levels of serum Vitamin A (average 1701 μg/L, range: 405-4448 μg/L) than dogs of the control group (average: 978 μg/L, range: 139 μg/L &#8211; 1904 μg/L). The study dogs also had significantly higher (P &lt; 0.001) serum Vitamin E levels (average: 36.0 μg/L, range: 15.3-83.7 μg/L) than the control group (average: 20.4 μg/L, range: 1,9-54.6 μg/L).<br />
This study suggests that dogs with pancreatitis have a different metabolism of Vitamin A and E compared to dogs with other diseases and humans with pancreatitis. In the course of pancreatitis, a release of Vitamin A and E into the blood stream due to necrotic processes of tissue may be discussed in this species</p>
<div class="hr-thin"></div>
<blockquote>
<h4>Characterization of 22 canine pancreatic carcinomas and review of literature</h4>
</blockquote>
<p>Autor: Aupperle-Lellbach H, Törner K, Staudacher E, Müller E, Steiger K, Klopfleisch R</p>
<p>Quelle: Journal of comparative pathology 2019. 173: 71–82.<br />
doi.org/10.1016/j.jcpa.2019.10.008</p>
<p><strong>Abstract:</strong><br />
Pancreatic carcinomas are rare in dogs and clinical signs are mostly non-specific. The literature on clinically and pathologically characterized canine exocrine pancreatic tumours is limited to 76 cases reported since 1963.<br />
This retrospective study analysed formalin-fixed samples of pancreatic carcinomas from 22 dogs, obtained during elective exploratory surgery (n = 16) or if the dog was humanely destroyed (n = 6). Tumours were diagnosed according to the World Health Organization classification of tumours of the pancreas of domestic animals. In seven cases, blood samples taken during or shortly before surgery were analysed for concentrations of alpha-amylase, 1,2-o-dilauryl-rac-glycero-3-glutaric acid-(6&#8242;-methylresorufin) ester lipase (DGGR lipase), C-reactive protein (CRP), alanine aminotransferase, glutamate dehydrogenase, alkaline phosphatase (ALP), canine trypsin-like immunoreactivity (cTLI) and canine pancreatic lipase immunoreactivity (cPLI). Neutrophil and lymphocyte numbers were determined as part of a complete blood count.<br />
Clinical signs were non-specific and included vomiting, inappetence and diarrhoea. Acinar carcinomas were most common (19/22) and observed growth patterns included: solid (n = 14), acinar (n = 5), clear cell (n = 3), mucinous (n = 2), trabecular (n = 1) or rosette-like (n = 1), occurring as a single pattern or in combination. Ductal carcinomas were identified in three cases. Pancreatitis was a common additional histological finding; five dogs had mild and nine dogs had severe pancreatitis. cPLI, DGGR lipase, cTLI and CRP were elevated in 5/5 acinar carcinomas. All liver enzymes were elevated in three of these five animals and ALP was increased in 4/5 dogs. Two dogs with ductal pancreatic carcinomas showed normal cPLI concentrations. One had increased CRP, liver enzymes and leucocytosis with neutrophilia, the other had elevated DGGR lipase and cTLI concentrations.<br />
Clinical findings in canine pancreatic carcinomas were non-specific and simultaneous inflammation can mask the detection of the underlying neoplasm in clinical examination and laboratory testing.</p>
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<div id="c6649" class="csc-frame csc-frame-rulerAfter csc-space-after-25">
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<h4 class="csc-firstHeader">Retrospective evaluation of vector-borne infections in dogs imported from the Mediterranean region and southeastern Europe(2007–2015)</h4>
</blockquote>
<p class="bodytext">Ingo Schäfer, Maria Volkmann, Pamela Beelitz, Roswitha Merle, Elisabeth Müller and Barbara Kohn</p>
<p>Parasit Vectors. 2019 Jan 11;12(1)</p>
<p><a href="https://parasitesandvectors.biomedcentral.com/articles/10.1186/s13071-018-3284-8" target="_blank" rel="noopener noreferrer">parasitesandvectors.biomedcentral.com/articles/10.1186/s13071-018-3284-8</a></p>
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<div id="c6637" class="csc-frame csc-frame-rulerAfter csc-space-after-25">
<h1></h1>
<blockquote>
<h4>Rabbit haemorrhagic disease virus type 2 in hares in England</h4>
</blockquote>
<p class="bodytext">Diana J. Bell, Jonathan P. Davis, Matthew Gardner, Alex M. Barlow, Mara Rocchi, Michaela Gentil, Rand J. Wilson</p>
<p>The Veterinary record 184(4)<br />
DOI: 10.1136/vr.l337</p>
<p><a href="https://search.proquest.com/openview/76c618af1915fc92a26def5ec7ad14f4/1?pq-origsite=gscholar&amp;amp;cbl=2041027" target="_blank" rel="noopener noreferrer">search.proquest.com/openview/76c618af1915fc92a26def5ec7ad14f4/1</a></p>
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<div id="c6636" class="csc-frame csc-frame-rulerAfter csc-space-after-25">
<h1></h1>
<blockquote>
<h4>Season and sex specific thyroid hormone levels in different European tortoise species (Testudo spp.)</h4>
</blockquote>
<p class="bodytext">Leineweber C, Öfner S, Mathes K, Marschang RE, Stöhr AC.</p>
<p>Proceedings Zoo Wildl Health Conf, Kolården, Sweden. 12.-15</p>
<p><a href="http://www.zoowildlifehealth.org/" target="_blank" rel="noopener noreferrer">www.zoowildlifehealth.org</a></p>
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<h1></h1>
<blockquote>
<h4>Reptile infectious diseases with a focus on Europe</h4>
</blockquote>
<p class="bodytext">Marschang RE.</p>
<p>Proceedings Zoo Wildl Health Conf, Kolården, Sweden. 12.-15</p>
<p><a href="http://www.zoowildlifehealth.org/" target="_blank" rel="noopener noreferrer">www.zoowildlifehealth.org</a></p>
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<h1></h1>
<blockquote>
<h4>Antiviral Therapy</h4>
</blockquote>
<p class="bodytext">Marschang RE.</p>
<p>Mader&#8217;s Reptile and Amphibian Medicine and Surgery</p>
<p><a href="https://www.elsevier.com/books/maders-reptile-and-amphibian-medicine-and-surgery/divers/978-0-323-48253-0" target="_blank" rel="noopener noreferrer">www.elsevier.com/books/maders-reptile-and-amphibian-medicine-and-surgery/divers/978-0-323-48253-0</a></p>
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<div id="c6632" class="csc-frame csc-frame-rulerAfter csc-space-after-25">
<h1></h1>
<blockquote>
<h4>Virology. In: Divers SJ, Stahl SJ (eds.)</h4>
</blockquote>
<p class="bodytext">Marschang RE.</p>
<p>Mader&#8217;s Reptile and Amphibian Medicine and Surgery</p>
<p><a href="https://www.elsevier.com/books/maders-reptile-and-amphibian-medicine-and-surgery/divers/978-0-323-48253-0" target="_blank" rel="noopener noreferrer">www.elsevier.com/books/maders-reptile-and-amphibian-medicine-and-surgery/divers/978-0-323-48253-0</a></p>
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<div id="c6631" class="csc-frame csc-frame-rulerAfter csc-space-after-25">
<h1></h1>
<blockquote>
<h4>Infectious diseases. In: Girling SJ, Raiti P (eds.)</h4>
</blockquote>
<p class="bodytext">Marschang RE, Chitty J.</p>
<p>BSAVA Manual of Reptiles, 3rd Edition. British Small Animal Veterinary Association, Gloucester, UK.</p>
<p><a href="https://www.bsavalibrary.com/content/book/10.22233/9781905319794" target="_blank" rel="noopener noreferrer">www.bsavalibrary.com/content/book/10.22233/9781905319794</a></p>
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<div id="c6625" class="csc-frame csc-frame-rulerAfter csc-space-after-25">
<h1></h1>
<blockquote>
<h4>Reptarenaviruses in apparently healthy snakes in an Australian zoological collection</h4>
</blockquote>
<p class="bodytext">Hyndman TH, Marschang RE, Bruce M, Clark P, Vitali SD.</p>
<p>Austr Vet J. 97(4): Wildlife &amp; Zoos p.93-102<br />
doi:10.1111/avj.12792</p>
<p><a href="https://onlinelibrary.wiley.com/doi/abs/10.1111/avj.12792" target="_blank" rel="noopener noreferrer">onlinelibrary.wiley.com/doi/abs/10.1111/avj.12792</a></p>
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<div id="c6624" class="csc-frame csc-frame-rulerAfter csc-space-after-25">
<h1></h1>
<blockquote>
<h4>Correlation of BRAF Variant V595E, Breed, Histological Grade and Cyclooxygenase-2 Expression in Canine Transitional Cell Carcinomas</h4>
</blockquote>
<p class="bodytext">Julia M. Grassinger, Sophie Merz, Heike Aupperle-Lellbach, Hanna Erhard and Robert Klopfleisch</p>
<p>Vet. Sci. 2019, 6(1),<br />
<a href="https://doi.org/10.3390/vetsci6010031" target="_blank" rel="noopener noreferrer">doi.org/10.3390/vetsci6010031</a></p>
<p><a href="https://www.mdpi.com/journal/vetsci/special_issues/comparative_oncology" target="_blank" rel="noopener noreferrer">www.mdpi.com/journal/vetsci/special_issues/comparative_oncology</a></p>
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<div id="c6610" class="csc-frame csc-frame-rulerAfter csc-space-after-25">
<h1></h1>
<blockquote>
<h4>CMAH genotyping survey for blood types A, B and C(AB) in purpose-bredcats</h4>
</blockquote>
<p class="bodytext">(A. Kehl, E. Mueller and U.Giger)</p>
<p>ANIMAL GENETICS, First published: 10 March 2019<br />
<a href="https://doi.org/10.1111/age.12778" target="_blank" rel="noopener noreferrer">doi.org/10.1111/age.12778</a></p>
<p><a href="https://onlinelibrary.wiley.com/doi/abs/10.1111/age.12778?af=R&amp;amp" target="_blank" rel="noopener noreferrer">onlinelibrary.wiley.com/doi/abs/10.1111/age.12778</a>;</p>
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<div id="c6609" class="csc-frame csc-frame-rulerAfter csc-space-after-25">
<h1></h1>
<blockquote>
<h4>MRI in a dog with confirmed pseudorabies infection</h4>
</blockquote>
<p class="bodytext">Engelhardt S, Schneider S, Buder A, Aupperle-Lellbach H, Pfeil I.</p>
<p>Tierarztl Prax Ausg K Kleintiere Heimtiere. 2019 Aug;47(4):272-281. p.272-281</p>
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</div>
<div id="c6557" class="csc-frame csc-frame-rulerAfter csc-space-after-25">
<h1></h1>
<blockquote>
<h4>AKNA Frameshift Variant in Three Dogs with Recurrent Inflammatory Pulmonary Disease</h4>
</blockquote>
<p class="bodytext">Genes (Basel). 2019 Jul 26;10(8). pii: E567<br />
doi: 10.3390/genes10080567</p>
<p><a href="https://www.mdpi.com/2073-4425/10/8/567" target="_blank" rel="noopener noreferrer">www.mdpi.com/2073-4425/10/8/567</a></p>
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</div>
<div id="c6556" class="csc-frame csc-frame-rulerAfter csc-space-after-25">
<h1></h1>
<blockquote>
<h4>Expression of Myoepithelial Markers in Mammary Carcinomas of 119 Pet Rabbits</h4>
</blockquote>
<p class="bodytext">Degner S, Schoon HA, Degner S, Baudis M, Schandelmaier C, Aupperle-Lellbach H, Schöniger S.</p>
<p>Animals (Basel). 2019 Sep 28;9(10). pii: E740.<br />
doi: 10.3390/ani9100740.</p>
<p><a href="https://www.thieme-connect.com/products/ejournals/html/10.1055/a-0987-8212" target="_blank" rel="noopener noreferrer">www.thieme-connect.com/products/ejournals/html/10.1055/a-0987-8212</a></p>
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</div>
<div id="c6553" class="csc-frame csc-frame-rulerAfter csc-space-after-25">
<h1></h1>
<blockquote>
<h4>Three genetically distinct ferlaviruses have varying effects on infected corn snakes (Pantherophis guttatus)</h4>
</blockquote>
<p class="bodytext">Pees M, Schmidt V, Papp T, Gellért Á, Abbas M, Starck JM, Neul A, Marschang RE.</p>
<p>PLoS One. 2019 Jun 4;14(6):e0217164.<br />
doi: 10.1371/journal.pone.0217164</p>
<p><a href="https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0217164" target="_blank" rel="noopener noreferrer">journals.plos.org/plosone/article</a></p>
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</div>
<div id="c6552" class="csc-frame csc-frame-rulerAfter csc-space-after-25">
<h1></h1>
<blockquote>
<h4>Primary Solid and Cystic Tumours of the Exocrine Pancreas in Cats</h4>
</blockquote>
<p class="bodytext">Törner K, Aupperle-Lellbach H, Staudacher A, Staudacher M, Steiger K.</p>
<p>J Comp Pathol. 2019 May;<br />
doi: 10.1016/j.jcpa.2019.04.002</p>
<p><a href="https://www.sciencedirect.com/science/article/pii/S0021997518305346" target="_blank" rel="noopener noreferrer">www.sciencedirect.com/science/article/pii/S0021997518305346</a></p>
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<p>&nbsp;</p>
</div>
<div id="c6506" class="csc-frame csc-frame-rulerAfter csc-space-after-25">
<blockquote>
<h4>IDENTIFICATION OF HELODERMATID ADENOVIRUS 2 IN A CAPTIVE CENTRAL BEARDED DRAGON (POGONA VITTICEPS), WILD GILA MONSTERS (HELODERMA SUSPECTUM), AND A DEATH ADDER (ACANTHOPHIS ANTARCTICUS)</h4>
</blockquote>
<p class="bodytext">Benge SL, Hyndman TH, Funk RS, Marschang RE, Schneider R, Childress AL, Wellehan JFX Jr.</p>
<p>J Zoo Wildl Med. 2019 Mar 1;50(1) p.238-242<br />
doi: 10.1638/2017-0016</p>
<p><a href="https://bioone.org/journals/journal-of-zoo-and-wildlife-medicine/volume-50/issue-1/2017-0016/IDENTIFICATION-OF-HELODERMATID-ADENOVIRUS-2-IN-A-CAPTIVE-CENTRAL-BEARDED/10.1638/2017-0016.short" target="_blank" rel="noopener noreferrer">bioone.org/journals/journal-of-zoo-and-wildlife-medicine/volume-50/issue-1/2017-0016/IDENTIFICATION-OF-HELODERMATID-ADENOVIRUS-2-IN-A-CAPTIVE-CENTRAL-BEARDED/10.1638/2017-0016.short</a></p>
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</div>
<div id="c6501" class="csc-frame csc-frame-rulerAfter csc-space-after-25">
<blockquote>
<h1></h1>
<h4>Reptarenaviruses in apparently healthy snakes in an Australian zoological collection</h4>
</blockquote>
<p class="bodytext">Aust Vet J. 2019 Apr;97(4):93-102<br />
doi: 10.1111/avj.12792</p>
<p><a href="https://onlinelibrary.wiley.com/doi/pdf/10.1111/avj.12792" target="_blank" rel="noopener noreferrer">onlinelibrary.wiley.com/doi/pdf/10.1111/avj.12792</a></p>
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</div>
<div id="c6499" class="csc-frame csc-frame-rulerAfter csc-space-after-25">
<h1></h1>
<blockquote>
<h4>Changes in anti-Müllerian hormone concentrations in bitches throughout the oestrous cycle</h4>
</blockquote>
<p class="bodytext">Walter B, Feulner H, Otzdorff C, Klein R, Reese S, Meyer-Lindenberg A.</p>
<p>Theriogenology. 2019 Mar 15;127<br />
<a href="https://doi.org/10.1016/j.theriogenology.2019.01.007" target="_blank" rel="noopener noreferrer">doi.org/10.1016/j.theriogenology.2019.01.007</a></p>
<p><a href="https://www.sciencedirect.com/science/article/abs/pii/S0093691X18308203" target="_blank" rel="noopener noreferrer">www.sciencedirect.com/science/article/abs/pii/S0093691X18308203</a></p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
</div>
<div id="c6498" class="csc-frame csc-frame-rulerAfter csc-space-after-25">
<blockquote>
<h4>Cytokeratin expression profiles of canine epithelial tissues</h4>
</blockquote>
<p class="bodytext">Rickmeyer T, Jäger K, Schöniger S, Schoon HA.</p>
<p class="bodytext">Histol Histopathol. 2019 Jun;34(6):<br />
doi: 10.14670/HH-18-070</p>
<p class="bodytext"><a href="https://europepmc.org/abstract/med/30499583" target="_blank" rel="noopener noreferrer">europepmc.org/abstract/med/30499583</a></p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
</div>
<div id="c6471" class="csc-frame csc-frame-rulerAfter csc-space-after-25">
<blockquote>
<h4>Canine tissue-associated CD4+CD8α+ double-positive T cells are an activated T cell subpopulation with heterogeneous functional potential</h4>
</blockquote>
<p class="bodytext">Friederike V. Rabiger, Doris Bismarck, Martina Protschka,Gabriele Köhler, Peter F. Moore, Mathias Büttner, Heiner von Buttlar, Gottfried Alber, Maria Eschke</p>
<p class="bodytext">PLoS ONE 14(3): e0213597</p>
<p class="bodytext"><a href="https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0213597" target="_blank" rel="noopener noreferrer">journals.plos.org/plosone/article</a></p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
</div>
<div id="c6470" class="csc-frame csc-frame-rulerAfter csc-space-after-25">
<blockquote>
<h4>Detection of nidoviruses, Mycoplasma, and Chlamydia in pythons</h4>
</blockquote>
<p class="bodytext">Marschang RE, Racz K, Müller E, Kolesnik E. 2019</p>
<p class="bodytext">Proceedings Exoticscon, St. Louis, Missouri. 29. September- 3. October. p. 664</p>
</div>
<div id="c6469" class="csc-frame csc-frame-rulerAfter csc-space-after-25">
<blockquote>
<h4>Prevalence of herpesviruses in chelonians in veterinary practice in Europe</h4>
</blockquote>
<p class="bodytext">Marschang RE, Kolesnik E, Müller E. 2019</p>
<p class="bodytext">Proceedings Exoticscon, St. Louis, Missouri. 29. September- 3. October. p. 556</p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
</div>
<div id="c6468" class="csc-frame csc-frame-rulerAfter csc-space-after-25">
<blockquote>
<h4>Composition of ferret uroliths in North America and Europe: 1055 cases (2010-2018)</h4>
</blockquote>
<p class="bodytext">Hanah E, Di Girolamo N, Marschang R, Brandão J, Moore A, Desprez I, Lulich J. 2019</p>
<p class="bodytext">Proceedings Exoticscon, St. Louis, Missouri. 29. September- 3. October. p. 403.</p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
</div>
<div id="c6401" class="csc-frame csc-frame-rulerAfter csc-space-after-15">
<blockquote>
<h4>Prevalence of Diarrheagenic Escherichia coli Bacteria in Fecal Samples from Dogs Showing Signs of Gastrointestinal Disorders and a Clinically Healthy Control Group</h4>
</blockquote>
<p class="bodytext">(Ronnie Gueta, Hader C, Mueller AS, Heusinger T, and Mueller E)<br />
JSMC Microbiology, Short Communication, p.5  <a href="https://www.jsmcentral.org/Microbiology/" target="_blank" rel="noopener noreferrer">https://www.jsmcentral.org/Microbiology/</a></p>
<p><a class="external-link-new-window" title="Öffnet einen externen Link in einem neuen Fenster" href="https://www.jsmcentral.org/Microbiology/jsmcm671888.pdf" target="_blank" rel="noopener noreferrer">Link to PDF</a></p>
<p><b>Abstract<br />
</b></p>
<div>
<p class="bodytext">Infections with enteropathogenic bacteria are a common cause for gastrointestinal symptoms in dogs. However, screening for Escherichia coli (E. coli) strains such as EHEC, EPEC and ETEC is seldom part of the veterinary approach to establishing differential diagnoses. Consequently, little is known, especially in Germany, about the prevalence of diarrheagenic E.coli strains and their role in gastrointestinal diseases in dogs. This paper will contrast the frequency of virulence markers from E.Coli pathotypes demonstrated in dogs with gastrointestinal symptoms as well as a control group without clinical findings. Fecal samples from 410 dogs in Germany were cultured, of which 368 were obtained from symptomatic dogs and 42 samples served as control. E.coli isolates were subsequently analyzed for the presence of virulence factor encoding genes specific to diarrheagenic E. coli pathotypes by PCR (stx1, stx2, sta and eae). Eae genes were detected in 17.1% of samples from symptomatic dogs and 26.2% of control group samples, respectively. Sta genes were detected in 2.4% of samples from symptomatic dogs and 9.2% of samples in the control group, respectively. The Shiga toxinen coding genes stx1 and stx2 could only be detected in E. coli cultures from dogs with gastrointestinal symptoms. These results suggest that while infections with diarrheagenic strains of E.coli can be associated with gastro intestinal illness, these strains may be present in absence of a clinical manifestation. Considering the possibility of a zoonotic potential of Diarrheagenic E. coli strains, a differentiation between non-pathogenic and virulent strains may yield valuable additional information for diagnostic and therapeutical purposes.</p>
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</div>
<div></div>
</div>
<div id="c6358" class="csc-frame csc-frame-rulerAfter csc-space-after-15">
<blockquote>
<h4>Rabbit haemorrhagic disease virus type 2 in hares in England</h4>
</blockquote>
<p class="bodytext">Diana J. Bell, Jonathan P. Davis, Matthew Gardner, Alex M. Barlow, Mara Rocchi, Michaela Gentil, Rand J. Wilson<br />
The Veterinary record 184(4):127.2-128<br />
DOI: 10.1136/vr.l337</p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
</div>
<div id="c6353" class="csc-frame csc-frame-rulerAfter csc-space-after-15">
<blockquote>
<h4>Comparison of three different PCR protocols for the detection of ferlaviruses</h4>
</blockquote>
<p class="bodytext"><b>BMC Veterinary Researchvolume 15, Article number: 281 (2019) p.1-8</b><br />
(Ekaterina Kolesnik, Timothy H. Hyndman, Elisabeth Müller, Michael Pees &amp; Rachel E. Marschang)<br />
<a href="https://doi.org/10.1186/s12917-019-2028-0" target="_blank" rel="noopener noreferrer">https://doi.org/10.1186/s12917-019-2028-0</a><br />
<a href="https://bmcvetres.biomedcentral.com/articles/10.1186/s12917-019-2028-0" target="_blank" rel="noopener noreferrer">https://bmcvetres.biomedcentral.com/articles/10.1186/s12917-019-2028-0</a></p>
<p class="bodytext"><b>Abstract</b></p>
<p class="bodytext"><b>Background</b><br />
Ferlaviruses are important pathogens in snakes often associated with respiratory and neurological disease. The detection of ferlaviral RNA by PCR is considered to be the most reliable method for the diagnosis of infection. The PCRs that have been used most commonly for this purpose have not been properly assessed to determine their sensitivity, specificity and ability to detect the known genetic diversity of this group of viruses. The aim of this study was to compare three published PCR protocols so that a single method could be recommended to laboratories that perform this testing.</p>
<p class="bodytext"><b>Results</b><br />
Comparisons were carried out using cell culture isolates and tissues from snakes infected with specific virus genotypes. A single round PCR targeting a short segment of the viral polymerase (L) gene provided the highest sensitivity and specificity, and detected isolated ferlaviruses from all four described genogroups, as well as from tissues of infected snakes.</p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
</div>
<div id="c6261" class="csc-frame csc-frame-rulerAfter csc-space-after-15">
<blockquote>
<h4>Three genetically distinct ferlaviruses have varying effects on infected corn snakes (Pantherophis guttatus)</h4>
</blockquote>
<p class="bodytext">Pees M, Schmidt V, Papp T, Gellért À, Starck JM, Neul A, Marschang RE. 2019.</p>
<p>1 Department for Birds and Reptiles, University Teaching Hospital, University of Leipzig, Leipzig, Germany,<br />
2 Institute for Veterinary Medical Research, Centre for Agricultural Research, the Hungarian Academy of<br />
Sciences, Budapest, Hungary,<br />
3 Institute for Environmental and Animal Hygiene, University of Hohenheim, Stuttgart, Germany<br />
4 Department of Biology II LMU München–Biocenter, Munich, Germany,<br />
5 Laboklin, Bad Kissingen, Germany</p>
<p><b>Abstract</b></p>
<p>Ferlaviruses are important pathogens in snakes and other reptiles. They cause respiratory and neurological disease in infected animals and can cause severe disease outbreaks. Isolates from this genus can be divided into four genogroups–A, B, and C, as well as a more distantly related sister group, “tortoise”. Sequences from large portions (5.3 kb) of the genomes of a variety of ferlavirus isolates from genogroups A, B, and C, including the genes coding the surface glycoproteins F and HN as well as the L protein were determined and compared. In silico analyses of the glycoproteins of genogroup A, B, and C isolates were carried out. Three isolates representing these three genogroups were used in transmission studies with corn snakes (Pantherophis guttatus), and clinical signs, gross and histopathology, electronmicroscopic changes in the lungs, and isolation of bacteria from the lungs were evaluated. Analysis of the sequences supported the previous categorization of ferlaviruses into four genogroups, and criteria for definition of ferlavirus genogroups and species were established based on sequence identities (80% resp. 90%). Analysis of the ferlavirus glycoprotein models showed parallels to corresponding regions of other paramyxoviruses. The transmission studies showed clear differences in the pathogenicities of the three virus isolates used. The genogroup B isolate was the most and the group A virus the least pathogenic. Reasons for these differences were not clear based on the differences in the putative structures of their respective glycoproteins, although e.g. residue and consequential structure variation of an extended cleavage site or changes in electrostatic charges at enzyme binding sites could play a role. The presence of bacteria in the lungs of the infected animals also clearly corresponded to increased pathogenicity. This study contributes to knowledge about the structure and phylogeny of ferlaviruses and lucidly demonstrates differences in pathogenicity between strains of different genogroups.</p>
<p><a class="download" title="Startet den Datei-Download" href="https://laboklin.com/fileadmin/FILES/Downloads/Publikationen/english/2019/Pees_et_al_Ferla_transmission_pathol_PLoSONE_2019.pdf">PDF Download</a></p>
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<p>&nbsp;</p>
</div>
<div id="c6260" class="csc-frame csc-frame-rulerAfter csc-space-after-15">
<blockquote>
<h4>Detection and Characterization of Invertebrate Iridoviruses Found in Reptiles and Prey Insects in Europe over the Past Two Decades</h4>
</blockquote>
<p class="bodytext">Papp T, Marschang RE. 2019.</p>
<p class="bodytext">1 Institute for Veterinary Medical Research, Centre for Agricultural Research, Hungarian Academy of Sciences, Hungaria krt 21, H-1143 Budapest, Hungary<br />
2 Cell Culture Lab, Microbiology Department, Laboklin GmbH &amp; Co. KG, 97688 Bad Kissingen, Germany<br />
* Correspondence: rachel.marschang@gmail.com</p>
<p class="bodytext"><b>Abstract</b></p>
<p class="bodytext">Invertebrate iridoviruses (IIVs), while mostly described in a wide range of invertebrate<br />
hosts, have also been repeatedly detected in diagnostic samples from poikilothermic vertebrates<br />
including reptiles and amphibians. Since iridoviruses from invertebrate and vertebrate hosts dier<br />
strongly from one another based not only on host range but also on molecular characteristics,<br />
a series of molecular studies and bioassays were performed to characterize and compare IIVs from<br />
various hosts and evaluate their ability to infect a vertebrate host. Eight IIV isolates from reptilian<br />
and orthopteran hosts collected over a period of six years were partially sequenced. Comparison of<br />
eight genome portions (total over 14 kbp) showed that these were all very similar to one another<br />
and to an earlier described cricket IIV isolate, thus they were given the collective name lizard–cricket<br />
IV (Liz–CrIV). One isolate from a chameleon was also subjected to Illumina sequencing and almost<br />
the entire genomic sequence was obtained. Comparison of this longer genome sequence showed<br />
several dierences to the most closely related IIV, Invertebrate iridovirus 6 (IIV6), the type species of<br />
the genus Iridovirus, including several deletions and possible recombination sites, as well as insertions<br />
of genes of non-iridoviral origin. Three isolates from vertebrate and invertebrate hosts were also<br />
used for comparative studies on pathogenicity in crickets (Gryllus bimaculatus) at 20 and 30 C.<br />
Finally, the chameleon isolate used for the genome sequencing studies was also used in a transmission<br />
study with bearded dragons. The transmission studies showed large variability in virus replication<br />
and pathogenicity of the three tested viruses in crickets at the two temperatures. In the infection<br />
study with bearded dragons, lizards inoculated with a Liz–CrIV did not become ill, but the virus<br />
was detected in numerous tissues by qPCR and was also isolated in cell culture from several tissues.<br />
Highest viral loads were measured in the gastro-intestinal organs and in the skin. These studies<br />
demonstrate that Liz–CrIV circulates in the pet trade in Europe. This virus is capable of infecting<br />
both invertebrates and poikilothermic vertebrates, although its involvement in disease in the latter<br />
has not been proven.</p>
<p><a class="download" title="Startet den Datei-Download" href="https://laboklin.com/fileadmin/FILES/Downloads/Publikationen/english/2019/Papp_and_Marschang_IIV_vertebrates_Viruses_2019.pdf">PDF download</a></p>
</div>
<div class="hr-thin"></div>
<p>&nbsp;</p>
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<blockquote>
<h4>IDENTIFICATION OF HELODERMATID ADENOVIRUS 2 IN A CAPTIVE CENTRAL BEARDED DRAGON (POGONA VITTICEPS), WILD GILA MONSTERS (HELODERMA SUSPECTUM), AND A DEATH ADDER (ACANTHOPHIS ANTARCTICUS)</h4>
</blockquote>
<p class="bodytext">Authors: Shemi L. Benge, Timothy H. Hyndman, Richard S. Funk, Rachel<br />
E. Marschang, Renata Schneider, et. al.<br />
Source: Journal of Zoo and Wildlife Medicine, 50(1) : 238-242<br />
Published By: American Association of Zoo Veterinarians<br />
URL: <a href="https://doi.org/10.1638/2017-0016" target="_blank" rel="noopener noreferrer">doi.org/10.1638/2017-0016</a></p>
<p class="bodytext"><b>Abstract</b></p>
<p class="bodytext">Adenoviruses are medium-sized DNA viruses with very high host fidelity. The phylogenetic relationships of the adenoviruses strongly resemble that of their hosts, consistent with evolutionary codivergence. The genus Atadenovirus appears to have evolved in squamate hosts. Perhaps the best known of the squamate adenoviruses is Agamid adenovirus 1 (AgAdV1), found most commonly in central bearded dragons (Pogona vitticeps), where it is a prevalent cause of hepatitis/enteritis, especially in young animals. All previous reports of adenoviruses in bearded dragons were AgAdV1. Helodermatid adenovirus 2 (HeAdV2) was first seen in Mexican beaded lizards (Heloderma horridus). Subsequently, partial adenoviral polymerase gene sequence from a western bearded dragon (Pogona minor) in Australia was found to share 99% nucleotide homology with HeAdV2. This article reports the discovery of a virus identical to HeAdV2 in a captive central bearded dragon in Florida and wild Gila monsters (Heloderma suspectum) in Arizona. Additionally, a partial adenoviral polymerase gene sharing 98% homology with this HeAdV2 was discovered in a death adder (Acanthophis antarcticus) in Australia. These findings call into question the provenance of HeAdV2. Further studies of atadenoviral host range, diversity of adenoviruses in captive animals, and characterization of adenoviruses from wild squamates are indicated.</p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
</div>
<div id="c6223" class="csc-frame csc-frame-rulerAfter csc-space-after-15">
<blockquote>
<h4>Retrospective evaluation of vector-borne infections in dogs imported from the Mediterranean region and southeastern Europe(2007–2015)</h4>
</blockquote>
<p class="bodytext">Ingo Schäfer, Maria Volkmann, Pamela Beelitz, Roswitha Merle, Elisabeth Müller and Barbara Kohn<br />
<a class="external-link-new-window" title="Öffnet einen externen Link in einem neuen Fenster" href="https://doi.org/10.1186/s13071-018-3284-8" target="_blank" rel="noopener noreferrer">https://doi.org/10.1186/s13071-018-3284-8</a><br />
Parasites &amp; Vectors 2019; 12:30</p>
<p><b>Abstract</b><br />
Canine vector-borne infections have gained importance in Germany due to growing tourist traffic and an increased import of dogs from abroad. Endemic regions for pathogens such as Leishmania infantum, Hepatozoon canis, Ehrlichia canis, Anaplasma platys and Dirofilaria spp. are the Mediterranean area and southeastern Europe. Babesia species and Anaplasma phagocytophilum are present all over Europe. The objective of this retrospective study was to evaluate the prevalence of vector-borne infections in dogs imported from defined endemic countries in the Mediterranean area and southeastern Europe.</p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
</div>
<div id="c6095" class="csc-frame csc-frame-rulerAfter">
<blockquote>
<h4>Correlation of BRAF Variant V595E, Breed, Histological Grade and Cyclooxygenase-2 Expression in Canine Transitional Cell Carcinomas</h4>
</blockquote>
<p class="bodytext">by Julia M. Grassinger,Sophie Merz,Heike Aupperle-Lellbach,Hanna Erhard and Robert Klopfleisch</p>
<p class="bodytext">Vet. Sci. 2019, 6(1), 31; Published: 19 March 2019</p>
<p class="bodytext"><a href="https://doi.org/10.3390/vetsci6010031" target="_blank" rel="noopener noreferrer">doi.org/10.3390/vetsci6010031</a></p>
<p class="bodytext"><a href="https://www.mdpi.com/journal/vetsci/special_issues/comparative_oncology" target="_blank" rel="noopener noreferrer">www.mdpi.com/journal/vetsci/special_issues/comparative_oncology</a></p>
<p class="bodytext">Abstract</p>
<p class="bodytext">The presence of BRAF variant V595E, as well as an increased cyclooxygenase-2 (COX-2) expression in canine transitional cell carcinoma (TCC) are well-described in the literature. The aim of the present study was to investigate the correlation between breed (terrier versus non-terrier dogs), histological grade, COX-2 expression, and BRAF mutation in canine TCC. Therefore, transmural TCC biopsies from 65 dogs (15 terriers, 50 non-terriers) were graded histologically into low- and high-grade. Immunohistochemical evaluation of the intensity of COX-2 expression was performed using an immunoreactive score (IRS). Exon 15 of chromosome 16 was examined for the BRAF variant c.1799T&gt;A by TaqMan® SNP assay. TCC was low-grade in 20 cases (one terrier, 19 non-terriers) and high-grade in 45 cases (14 terriers, 31 non-terriers). Contrary to humans, histological grade was not significantly correlated to the intensity of COX-2 expression. BRAF mutation was detected in 11/15 (73%) TCC of terriers and in 18/50 (36%) TCC of non-terriers. Histological grade and BRAF mutation were not correlated significantly (p = 0.2912). Terriers had a considerably higher prevalence of high-grade tumors (p &lt; 0.0001), as well as of BRAF mutation (p ≤ 0.05) compared to non-terriers. In non-terriers, neoplasms with BRAF mutation showed a significantly higher intensity of COX-2 expression than those without BRAF mutation (p ≤ 0.05). In conclusion, in contrast to humans, testing for BRAF mutation in canine TCC is a sensitive diagnostic method especially in terriers (73%) and may be recommended as a screening test. However, evidence of BRAF mutation in canine TCC is not a predictor for the histological grade. Moreover, a positive correlation between histological grade and the intensity of COX-2 expression was not found. Further studies are necessary to clarify the clinical and prognostic relevance of the elevated intensity of COX-2 expression of TCC with BRAF mutation detected in non-terriers.</p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
</div>
<div id="c6099" class="csc-frame csc-frame-rulerAfter">
<blockquote>
<h4>Antiviral therapy</h4>
</blockquote>
<p class="bodytext">Marschang RE. 2019</p>
<p class="bodytext">Elsevier, St. Louis, Missouri, USA. Pp. 1160-1161</p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
</div>
<div id="c6098" class="csc-frame csc-frame-rulerAfter">
<blockquote>
<h4>Virology</h4>
</blockquote>
<p class="bodytext">Marschang RE. 2019</p>
<p class="bodytext">In: Divers SJ, Stahl SJ (eds.). Mader’s Reptile and Amphibian Medicine and Surgery, Elsevier, St. Louis, Missouri, USA. Pp. 247-269</p>
<div class="hr-thin"></div>
<p class="bodytext">
</div>
<div id="c6097" class="csc-frame csc-frame-rulerAfter">
<blockquote>
<h4>Infectious diseases</h4>
</blockquote>
<p class="bodytext">Marschang RE, Chitty J. 2019</p>
<p class="bodytext">In: Girling SJ, Raiti P (eds.). BSAVA Manual of Reptiles, 3rd Edition. British Small Animal Veterinary Association, Gloucester, UK. Pp. 423-442</p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
</div>
<div id="c6096" class="csc-frame csc-frame-rulerAfter">
<blockquote>
<h4>Reptarenaviruses in apparently healthy snakes in an Australian zoological collection</h4>
</blockquote>
<p class="bodytext">Hyndman TH, Marschang RE, Bruce M, Clark P, Vitali SD. 2019</p>
<p class="bodytext">Austr Vet J. 97(4): 93-102.</p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
</div>
<div id="c5914" class="csc-default">
<blockquote>
<h4>CMAH genotyping survey for blood types A, B and C (AB) in purpose-bredcats</h4>
</blockquote>
<p class="bodytext">ANIMAL GENETICS, First published: 10 March 2019<br />
A. Kehl, E. Mueller and U.Giger<br />
doi:10.1111/age.12778</p>
<p><a href="https://onlinelibrary.wiley.com/doi/abs/10.1111/age.12778?af=R&amp;" target="_blank" rel="noopener noreferrer">https://onlinelibrary.wiley.com/doi/abs/10.1111/age.12778?af=R&amp;</a></p>
<p>Summary<br />
In domestic cats, the AB blood group system consists of the three types A, B and C (also called AB). Mismatches can cause acute hemolytic transfusion reactions and hemolysis of the newborn (neonatal isoerythrolysis, NI). As blood types B and C are inherited recessively to A, breeders need to know the genotype to predict blood types in offspring and avoid NI. Several CMAH variants have been described as being associated with the b and ac alleles, and different genotyping schemes exist. Here, we genotyped 2145 cats with the original SNV panel, including SNVs c.142G&gt;A and ∆‐53, and our new scheme, with SNVs c.179G&gt;T, c.268T&gt;A and c.1322delT, to differentiate types A and B and added the SNV for the common ac (c.364C&gt;T). Based upon the new scheme, all samples were assigned the correct genotype. No discordances appeared for the A allele, and new breed‐specific SNVs (c.179G&gt;T, c.1322delT) for the b allele were discovered. Furthermore, the genotypes A/ac (type A), ac/ac (C) and ac/b (C) could be detected. We found the variant c.179G&gt;T in additional breeds: Ragdoll, Siberian, Scottish Fold, Chartreux, Neva Masquerade, British Shorthair and Highlander. Also, the variant c.364C&gt;T was detected in additional breeds: Bengal, British Shorthair, Maine Coon, and Scottish Fold. We conclude that our new SNV panel is superior in genotyping cats than the original SNV panel and assures correct assignments of types A, B and C to assist veterinary clinicians and breeders to recognize, confirm and avoid blood incompatibilities such as acute hemolytic transfusion reactions and NI.</p>
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		<title>2018 &#124; Publications English</title>
		<link>https://laboklin.com/en/2018-publications-english/</link>
		
		<dc:creator><![CDATA[Laboklin &#124; Bad Kissingen]]></dc:creator>
		<pubDate>Tue, 18 Dec 2018 07:31:32 +0000</pubDate>
				<category><![CDATA[2018]]></category>
		<category><![CDATA[Publications English]]></category>
		<guid isPermaLink="false">https://staging.laboklin.com/int/en/?p=4225</guid>

					<description><![CDATA[- Respiratory infections in chelonia<br>
- Quarantine and disease prevention<br>
- Diagnosis of infectious disease in reptiles<br>
- How I treat…viral infections in reptiles<br>
- Detection of infectious agents in popularly kept reptile species in Poland<br>
...]]></description>
										<content:encoded><![CDATA[<div class="wpb-content-wrapper"><div class="vc_row wpb_row vc_row-fluid dt-default" style="margin-top: 0px;margin-bottom: 0px"><div class="wpb_column vc_column_container vc_col-sm-12"><div class="vc_column-inner"><div class="wpb_wrapper">
	<div class="wpb_text_column wpb_content_element " >
		<div class="wpb_wrapper">
			<div id="c6675" class="csc-frame csc-frame-rulerAfter csc-space-after-25">
<blockquote>
<h4>Respiratory infections in chelonia</h4>
</blockquote>
<p class="bodytext">Marschang RE.<br />
SEVC, Madrid, Spain, 18.-20. October:</p>
<div class="hr-thin"></div>
</div>
<div id="c6674" class="csc-frame csc-frame-rulerAfter csc-space-after-25">
<h1></h1>
<blockquote>
<h4>Quarantine and disease prevention</h4>
</blockquote>
<p class="bodytext">Marschang RE.<br />
SEVC, Madrid, Spain, 18.-20. October</p>
<div class="hr-thin"></div>
</div>
<div id="c6673" class="csc-frame csc-frame-rulerAfter csc-space-after-25">
<h1></h1>
<blockquote>
<h4>Diagnosis of infectious disease in reptiles</h4>
</blockquote>
<p class="bodytext">Marschang RE.<br />
SEVC, Madrid, Spain, 18.-20. October:</p>
<div class="hr-thin"></div>
</div>
<div id="c6672" class="csc-frame csc-frame-rulerAfter csc-space-after-25">
<h1></h1>
<blockquote>
<h4>How I treat…viral infections in reptiles</h4>
</blockquote>
<p class="bodytext">Marschang RE.<br />
SEVC, Madrid, Spain, 18.-20. October:</p>
<div class="hr-thin"></div>
</div>
<div id="c6671" class="csc-frame csc-frame-rulerAfter csc-space-after-25">
<h1></h1>
<blockquote>
<h4>Detection of infectious agents in popularly kept reptile species in Poland</h4>
</blockquote>
<p class="bodytext">Pasterny J, Seń J, Kamiński G, Marciniak M, Stanicki K, Skomorucha L, Marschang RE<br />
Proceedings 2018 Joint EAZWV/AAZV/Leibniz-IZW Conference, Prague, Czech Republic. October 6-12:</p>
<p><a href="http://www.zoowildlifehealth.org/" target="_blank" rel="noopener noreferrer">www.zoowildlifehealth.org</a></p>
<div class="hr-thin"></div>
</div>
<div id="c6670" class="csc-frame csc-frame-rulerAfter csc-space-after-25">
<h1></h1>
<blockquote>
<h4>Adenoviruses in tortoises and turtles in Europe</h4>
</blockquote>
<p class="bodytext">Marschang RE, Kolesnik E, Müller E.<br />
Proceedings 2018 Joint EAZWV/AAZV/Leibniz-IZW Conference, Prague, Czech Republic. October 6-12:</p>
<p><a href="http://www.zoowildlifehealth.org/" target="_blank" rel="noopener noreferrer">www.zoowildlifehealth.org</a></p>
<div class="hr-thin"></div>
</div>
<div id="c6669" class="csc-frame csc-frame-rulerAfter csc-space-after-25">
<h1></h1>
<blockquote>
<h4>Reference intervals for plasma capillary zone electrophoresis in Hermann’s tortoises (Testudo hermanni) depending on season and sex</h4>
</blockquote>
<p class="bodytext">Leineweber C, Stöhr AC, Öfner S, Mathes K, Marschang RE.<br />
Proceedings 2018 Joint EAZWV/AAZV/Leibniz-IZW Conference, Prague, Czech Republic. October 6-12:</p>
<p><a href="http://www.zoowildlifehealth.org/" target="_blank" rel="noopener noreferrer">www.zoowildlifehealth.org</a></p>
<div class="hr-thin"></div>
</div>
<div id="c6668" class="csc-frame csc-frame-rulerAfter csc-space-after-25">
<h1></h1>
<blockquote>
<h4>Optimizing the detection of ferlaviruses</h4>
</blockquote>
<p class="bodytext">Marschang RE, Kolesnik E, Pees M, Hyndman T.<br />
Proceedings 2018 Joint EAZWV/AAZV/Leibniz-IZW Conference, Prague, Czech Republic. October 6-12</p>
<div class="hr-thin"></div>
</div>
<div id="c6663" class="csc-frame csc-frame-rulerAfter csc-space-after-25">
<h1></h1>
<blockquote>
<h4>What laboratories do veterinarians use for infectious disease diagnostics in reptiles and amphibians?</h4>
</blockquote>
<p class="bodytext">Marschang RE, Varble D, Hyndman T, Members of the ARAV Infectious Diseases Committee. 2018.<br />
ExoticsCon 2018 Proceedings. Atlanta, Georgia. 22.-27. September 2018</p>
<p><a href="http://www.exoticscon.org/" target="_blank" rel="noopener noreferrer">www.exoticscon.org</a></p>
<div class="hr-thin"></div>
</div>
<div id="c6661" class="csc-frame csc-frame-rulerAfter csc-space-after-25">
<h1></h1>
<blockquote>
<h4>Blood reference intervals für rabbits (Oryctolagus cuniculus) from routine diangnostic samples</h4>
</blockquote>
<p class="bodytext">Leineweber C, Müller E, Marschang R<br />
Tieärztliche Praxis 6/2018 S.393-398<br />
<a href="http://dx.doi.org/10.15654/TPK-180705" target="_blank" rel="noopener noreferrer">dx.doi.org/10.15654/TPK-180705</a></p>
<p><a href="https://www.schattauer.de/" target="_blank" rel="noopener noreferrer">www.schattauer.de</a></p>
<div class="hr-thin"></div>
</div>
<div id="c6658" class="csc-frame csc-frame-rulerAfter csc-space-after-25">
<h1></h1>
<blockquote>
<h4>Infectious diseases and immunology. In: Doneley B, Monks D, Jehnson R, Carmel B (eds.)</h4>
</blockquote>
<p class="bodytext">Hyndman T, Marschang RE<br />
Reptile Medicine and Surgery in Clinical Practice. Wiley Glcakwell, Hoboken, New Jersey, USA</p>
<div class="hr-thin"></div>
</div>
<div id="c6657" class="csc-frame csc-frame-rulerAfter csc-space-after-25">
<h1></h1>
<blockquote>
<h4>Diagnostic testing. In: Doneley B, Monks D, Jehnson R, Carmel B (eds.)</h4>
</blockquote>
<p class="bodytext">Marschang RE, Pasmans F, Hyndman T, Mitchell M, Martel A.<br />
Reptile Medicine and Surgery in Clinical Practice. Wiley Glcakwell, Hoboken, New Jersey, USA.</p>
<div class="hr-thin"></div>
</div>
<div id="c6653" class="csc-frame csc-frame-rulerAfter csc-space-after-25">
<h1></h1>
<blockquote>
<h4>Estrogen Receptor-α and Progesterone Receptor Expression in Mammary Proliferative Lesions of Female Pet Rabbits</h4>
</blockquote>
<p class="bodytext">Degner S, Schoon HA, Laik-Schandelmaier C, Aupperle-Lellbach H, Schöniger S.<br />
Vet Pathol. 2018 Nov;55(6):<br />
doi: 10.1177/0300985818788611</p>
<p><a href="https://journals.sagepub.com/doi/abs/10.1177/0300985818788611" target="_blank" rel="noopener noreferrer">journals.sagepub.com/doi/abs/10.1177/0300985818788611</a></p>
<div class="hr-thin"></div>
</div>
<div id="c6652" class="csc-frame csc-frame-rulerAfter csc-space-after-25">
<h1></h1>
<blockquote>
<h4>Molecular characterization of blood type A, B, and C (AB) in domestic cats and a CMAH genotyping scheme</h4>
</blockquote>
<p class="bodytext">Kehl A, Heimberger K, Langbein-Detsch I, Boehmer S, Raj K, Mueller E, Giger U.<br />
PLoS One. 2018 Sep 20;13(9):e0204287.<br />
<a href="https://doi.org/10.1371/journal.pone.0204287" target="_blank" rel="noopener noreferrer">doi.org/10.1371/journal.pone.0204287</a></p>
<p><a href="https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0204287" target="_blank" rel="noopener noreferrer">journals.plos.org/plosone/article</a></p>
<div class="hr-thin"></div>
</div>
<div id="c6651" class="csc-frame csc-frame-rulerAfter csc-space-after-25">
<h1></h1>
<blockquote>
<h4>Loss of connexin 43 in Sertoli cells provokes postnatal spermatogonial arrest, reduced germ cell numbers and impaired spermatogenesis.</h4>
</blockquote>
<p class="bodytext">Rode K, Weider K, Damm OS, Wistuba J, Langeheine M, Brehm R.<br />
Reprod Biol. 2018 Dec;18(4):<br />
<a href="https://doi.org/10.1016/j.repbio.2018.08.001" target="_blank" rel="noopener noreferrer">doi.org/10.1016/j.repbio.2018.08.001</a></p>
<p><a href="https://www.sciencedirect.com/science/article/pii/S1642431X17302371?via%3Dihub" target="_blank" rel="noopener noreferrer">www.sciencedirect.com/science/article/pii/S1642431X17302371</a></p>
<div class="hr-thin"></div>
</div>
<div id="c5921" class="csc-frame csc-frame-rulerAfter">
<h1></h1>
<blockquote>
<h4>A case of ocular infection with Onchocerca lupi in a dog from Germany</h4>
</blockquote>
<p class="bodytext">Hodzic,A., Hinney,B., König,S., Naucke,T.J., Duscher,G. &amp; Joachim,A. (2018)<br />
Transbound. Emerg. Dis. 65(1): e214-216.<br />
<a class="external-link-new-window" title="Öffnet einen externen Link in einem neuen Fenster" href="https://doi.org/10.1111/tbed.12715" target="_blank" rel="noopener noreferrer">doi: 10.1111/tbed.12715.</a></p>
<p><strong>Abstract<br />
</strong>Onchocerca lupi is an emerging zoonotic parasite infecting the ocular connective tissue of dogs, cats and humans. The only known case of canine ocular onchocerciasis in Germany was documented in 2002 in a shelter dog. However, the species of Onchocerca causing the infection could not be identified. Here, we report a case of the ocular infection with O. lupi in a dog, confirmed by PCR and sequencing of the cox1 gene. Further investigations are required to assess the risk factors for transmission and spread of the parasite in Germany.</p>
<div class="hr-thin"></div>
</div>
<div id="c5782" class="csc-frame csc-frame-rulerAfter">
<h1></h1>
<blockquote>
<h4>Prevalence of BRAF Variant V450E in urine, smears, and biopsies of canine transitional cell carcinoma</h4>
</blockquote>
<p class="bodytext">D. Breu<sup>1</sup>, P. Pantke<sup>2</sup>, M. Weiss<sup>1</sup>, A. Heusinger<sup>1</sup>, A. Kehl<sup>1</sup>, H. Aupperle-Lellbach<sup>1</sup></p>
<p class="bodytext">Transitional cell carcinomas (TCC) are the most common malignant tumors of the canine urinary tract. Mochizuki et al. (PLoS ONE 2015a, 10(6):e0129534; PLoS ONE 2015b, 10(12):e0144170) identified the BRAF variant V595E in approximately 85% of canine TCC cases by DNA sequencing of TCC tumor cells, both in frozen and paraffin-embedded tissue sections, as well as in urine. The objective of this study was to additionally establish these methods in routinely submitted cytological smears and to investigate the incidence of BRAF variant V595E in canine TCC in our material.</p>
<p class="bodytext">Biopsy samples (n=42), urine (n=46) and/or cytological smears (n=31) of 57 dogs with cystitis (n=20), urinary bladder polyps (n=5), TCC (n=29) or other pathological changes (n=3), submitted for routine diagnostics, were selected. DNA-isolation from paraffin material was performed using a QIAamp DNA FFPE Tissue Kit (Qiagen). Epithelial cells were removed from the smears with a swab. DNA was isolated from the urine and cytological smears with the use of MagNA Pure 96 (Roche Diagnostics) und MagNA Pure 96 DNA and Viral NA Small Volume Kit (Roche Diagnostics). Exon 15 was examined for the presence of the mutation (BRAF variant c.1799T&gt;A) by Sanger Sequencing, according to Mochizuki et al. (2015a,b). The analysis was performed with the genetic analyser 3130 and a software SeqScanner.</p>
<p class="bodytext">In 37/42 paraffin-embedded biopsies and 25/46 urine samples, a sufficient amount of good quality DNA was isolated. In all 16 ‘cell-rich’ smears DNA isolation and sequencing were successful, but not in the 15 ‘cell-poor’ smears. In all cases for which different sample materials were available, the results of BRAF analysis were identical in paraffin-embedded tissue, cytological smears and/or urine. In all animals with cystitis or a polyp, a BRAF variant could not be detected. In 18/27 dogs (66.6%) with a TCC the presence of both nucleobases was confirmed.</p>
<p class="bodytext">In summary, BRAF variant V595E analysis could be a future non-invasive and simple diagnostic tool to confirm a diagnosis of TCC in routine diagnostic samples including cytological smears that contain sufficient numbers of epithelial cells. However, it is important to note that only a positive identification of the mutation is diagnostic, as the variant could not be demonstrated in animals without TCC. Further research is necessary to investigate prognostic and therapeutic relevance of the mutation and if this variant analysis can also be used as an early detection method for TCC.</p>
<p><a class="download" title="Startet den Datei-Download" href="https://laboklin.com/fileadmin/FILES/Downloads/Poster/ECVIM_2018_Breu_Poster_BRAF_2.pdf">ECVIM 2018 Poster</a></p>
<p class="bodytext"><sup>1</sup>Laboklin GmbH &amp; Co KG, Bad Kissingen</p>
<p class="bodytext"><sup>2 </sup>AniCura Bielefeld, Tierärztliche Klinik für Kleintiere</p>
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<h4>Diagnostics of canine Leishmania infection by ELISA and/or PCR-a comparative study</h4>
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<p class="bodytext">D. Breu, J. Guthardt, E. Müller</p>
<p>LABOKLIN GmbH &amp; Co.KG, Bad Kissingen, Germany</p>
<p><b>Abstract</b><br />
Leishmaniosis is one of prevalent parasitic canine diseases widely spread in temperate zones. Canine leishmaniosis may manifest as subclinical illness, a self-limiting disease or severe and chronic disease with multiple organ involvement. Infected dogs are considered the main reservoirs for human visceral Leishmaniasis.</p>
<p class="bodytext" align="justify">Our study was aimed to evaluate the relationship between the two current diagnostic methods of canine <i>Leishmania</i> infection, namely anti-Leishmania antibody (Ab) assay by ELISA (Enzyme-Linked Immunosorbent Assay) and Leishmania-DNA assay by PCR (Polymerase Chain Reaction). Blood samples and, when available, other materials (tissue, swabs) were obtained from the dogs with suspected <i>Leishmania</i> infections or history of importation/travels in Germany.</p>
<p class="bodytext" align="justify"><a name="_GoBack"></a>In 2016 and 2017, we analysed a total of 15449 and 17789 blood samples, respectively, for <i>Leishmania </i>Ab assays and a total of 712 and 786 samples, respectively, for<i> Leishmania </i>DNA assays. In 2016, overall 19.6% and 19.8% of the samples were Ab-positive and DNA-positive. In 2017, overall 21.9% and 18.6% of the samples were Ab-positive and DNA-positive, respectively. Specifically concerning the samples subjected to both PCR and Ab assays (129/712 in 2016; 145/786 in 2017), we observed the following Ab profiles. In 2016 and 2017, seropositivities (by <i>Leishmania</i> unit or LE &gt;1.1) were 97.0% and 93.5%, respectively, in PCR+ cohorts, versus 31.6% and 32.5%, respectively, in PCR- cohorts. Notably, the PCR+/Ab+ cohorts showed Ab titres (mean) ~2 times higher than those of the PCR–/Ab+ cohorts (3.1 LE versus 1.7 LE). In summary, (1) PCR-positive samples were almost 100% Ab-positive, (2) PCR-negative samples were ~32% Ab-positive, and (3) in Ab-positive cases, PCR-positive samples had approximately twice higher Ab titres than PCR-negative samples.</p>
<p class="bodytext" align="justify">Our data suggested that PCR-positivity may be considered as the diagnostics generally confirming active Leishmaniosis which represented, in our study, an overall 20% of the tested samples. Other ~32% of the PCR-negative/sero-positive samples might be the cases where persistent/residual antibodies were present due to exposition to the parasite or past <i>Leishmania </i>infection, regardless of the clinical status of dogs.</p>
<p class="bodytext"><a class="download" title="Startet den Datei-Download" href="https://laboklin.com/fileadmin/FILES/Downloads/Poster/ECVIM_2018_Breu_Poster_Leish_1.pdf">ECVIM 2018 Poster</a></p>
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<h4>&#8220;Rabbit hemorrhagic disease viruses detected in pet rabbits in a commercial laboratory in Europe&#8221;</h4>
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<p class="bodytext">Journal of Exotic Pet Medicine 27 (2018),pp 27-30<br />
DOI: <a href="https://doi.org/10.1053/j.jepm.2017.11.003" target="_blank" rel="noopener noreferrer">https://doi.org/10.1053/j.jepm.2017.11.003</a><br />
(Rachel E. Marschang, Karola Weider, Hanna Erhard, Eva-Maria Klas, Claudia Laik-Schandelmaier)</p>
<p><b>ABSTRACT<br />
</b>Rabbit hemorrhagic disease (RHD) is an important cause of disease and mortality in wild and domestic European rabbits (Oryctolagus cuniculus) throughout the world. Testing for two distinct RHD virus types (RHDV/RHDVa and RHDV2) was carried out on samples collected from 684 rabbits submitted from veterinary practices and private owners throughout Europe between January, 2015 and June, 2017. Four (0.6%) were positive for RHDV/RHDVa and 257 (37.4%) were positive for RHDV2. RHDV/RHDVa was detected in individual samples from Germany and the Netherlands, while RHDV2 was found in animals from Germany, Great Britain, Luxembourg, The Netherlands, Spain, Switzerland, Poland, Belgium, Austria, Sweden, and Finland.</p>
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<h4>&#8220;Diagnostics of Canine Leishmania Infection by ELISA and/or PCR-a Comparative Study&#8221;</h4>
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<p class="bodytext"><a href="https://www.ecvimcongress.org/" target="_blank" rel="noopener noreferrer">ECVIM-CA 28th Annual Congress</a> September 6-8, 2018 Rotterdam, The Netherlands<br />
(D. Breu; J. Guthardt; E. Müller)</p>
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<h4>&#8220;A Novel CMAH Gene Variant Leading to Blood Type B in Ragdolls&#8221;</h4>
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<p class="bodytext"><a href="https://www.ecvimcongress.org/" target="_blank" rel="noopener noreferrer">ECVIM-CA 28th Annual Congress</a> September 6-8, 2018 Rotterdam, The Netherlands<br />
(A. Kehl; K. Heimberger; I. Langbein-Detsch; S. Boehmer; E. Mueller; U. Giger)</p>
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<h4>&#8220;Prevalence of BRAF Variant V450E in Urine, Smears, and Biopsies of Canine Transitional Cell Carcinoma&#8221;</h4>
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<p class="bodytext"><a href="https://www.ecvimcongress.org/" target="_blank" rel="noopener noreferrer">ECVIM-CA 28th Annual Congress</a> September 6-8, 2018 Rotterdam, The Netherlands<br />
(D. Breu; A. Heusinger; M. Weiss; A. Kehl; P. Pantke)</p>
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<h4>Miller-Fowler&#8217;s Zoo and Wild Animal Medicine Current Therapy, Volume 9, 1st Edition</h4>
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<p class="bodytext"><b>Editors</b>: R. Eric Miller &amp; Nadine Lamberski &amp; Paul Calle; <a class="external-link-new-window" title="Öffnet einen externen Link in einem neuen Fenster" href="https://www.elsevier.com/books/miller-fowlers-zoo-and-wild-animal-medicine-current-therapy-volume-9/miller/978-0-323-55228-8" target="_blank" rel="noopener noreferrer">ISBN: 9780323552288</a><br />
<b>Section 8: Emerging and Changing Infectious Diseases</b><br />
39. Emerging Reptile Viruses, Pp. 267-273 (Rachel Marschang)</p>
<p><b>Book description</b></p>
<p>Bringing together a globally diverse range of timely topics related to zoo and wild animals, Fowler s Zoo and Wild Animal Medicine, Volume 9 is an invaluable tool for any professional working directly with wildlife and zoo animals. The text s user-friendly format guides readers through biology, anatomy, and special physiology; reproduction; restraint and handling; housing requirements; nutrition and feeding; surgery and anesthesia; diagnostics, and therapeutics for each animal. Two new co-editors and a globally diverse group of expert contributors each lend their expertise on a wide range of new topics &#8211; including a new section on emerging wildlife diseases covering topics like MERS, Equine Herpesvirus, and Ebola in great apes. Other new topics integrated into this ninth volume include: stem cell therapy in zoo medicine, cardiac disease in great apes, disease risk assessment in field studies, Tasmanian devil tumors, and the latest information on the elephant herpes virus. With all its synthesized coverage of emerging trends, treatment protocols, and diagnostic updates new to the field, Fowler s is a reference you don t want to be without. Current therapy format ensures that each CT volume in the series covers all new topics that are relevant at the time of publication. Synthesized topics offer the right amount of depth &#8211; often fewer than 10 pages &#8211; to maintain an accessible format. General taxon-based format covers all terrestrial vertebrate taxa plus selected topics on aquatic and invertebrate taxa. Updated information from the Zoological Information Management System (ZIMS) has been incorporated to keep readers up to date on this worldwide system. Globally diverse panel of expert contributors each incorporate the latest research and clinical management of captive and free-ranging wild animals throughout the world. NEW! Two new co-editors (for a total of three editors) each lend their expertise on a wide range of new wild and zoo animal topics. NEW! Section on emerging wildlife diseases includes chapters on MERS, SARS, Ebola in great apes, and a variety of other emerging wildlife diseases.</p>
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<h1></h1>
<blockquote>
<h4>A novel MLPH variant in dogs with coat colour dilution</h4>
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<p class="bodytext">Anim Genet. 2018 Jan 19. doi: 10.1111/age.12632<br />
<a href="https://www.ncbi.nlm.nih.gov/pubmed/29349785" target="_blank" rel="noopener noreferrer">https://www.ncbi.nlm.nih.gov/pubmed/29349785</a><br />
(A. Bauer, A. Kehl, V. Jagannathan and T. Leeb)</p>
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<h4>Gastrointestinal B-lymphoblastic lymphoma in a dog: a case report</h4>
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<p class="bodytext">Veterinarni Medicina, 63, 2018 (01): 40–49<br />
<a href="http://www.agriculturejournals.cz/web/vetmed.htm?type=article&amp;id=114_2017-VETMED" target="_blank" rel="noopener noreferrer">http://www.agriculturejournals.cz/web/vetmed.htm?type=article&amp;id=114_2017-VETMED</a><br />
(Borska P, Husnik R, Fictum P, Kehl A, Leva L, Faldyna M)</p>
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<h4>Accuracy of a diagnostic model based on serum biochemical parameters in detecting cows at an increased risk of chronic fascioliasis</h4>
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<p class="bodytext">Veterinary Parasitology 2018, 254 , p.15-20</p>
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<p class="bodytext"><a class="external-link-new-window" title="Öffnet einen externen Link in einem neuen Fenster" href="https://doi.org/10.1016/j.vetpar.2018.02.038" target="_blank" rel="noopener noreferrer">https://doi.org/10.1016/j.vetpar.2018.02.038</a></p>
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<p class="bodytext">(Sławomir J. Kowalczyk, Michał Czopowicz, Corinna N. Weber, Elisabeth Müller, Jarosław Kaba)</p>
<p><b>Abstract</b></p>
<p>In adult cattle Fasciola hepatica infection usually follows a chronic subclinical course, and reduces both the milk yield and milk quality, resulting in considerable financial losses. Effective control of the disease is based on reliable identification of asymptomatically infected individuals, which now requires special parasitological or serological diagnostic tests. It is also known that F. hepatica infection induces alterations in some serum biochemical parameters. Therefore, the study was conducted to develop a model based on serum biochemical parameters allowing to identify cows at higher risk of chronic fascioliasis. Six hundred sixty eight adult dairy cows from 97 herds located in central and northeastern Poland were clinically examined, and blood and fecal samples from them were collected for a routine monitoring of fascioliasis and metabolic profile. Using the combination of fecal sedimentation test and indirect ELISA based on excretory/secretory products 203 cows, apparently healthy in clinical examination, were definitively classed as affected by (47 cows, 23.2%) or free from (156 cows, 76.8%) chronic fascioliasis. Their serum was screened for the activity of 4 enzymes (γ-glutamyl transpeptidase, glutamate dehydrogenase, aspartate aminotransferase, creatine kinase) and concentration of 18 other components (total bilirubin, total protein, albumin, globulin, urea, glucose, non-esterified fatty acids, β-hydroxybutyrate, sodium, potassium, chloride, calcium, magnesium, copper, zinc, iron, selenium, and haptoglobin). Logistic regression analysis was used to build 4 multivariable models allowing for identification of cows at risk of chronic fascioliasis. Then, the accuracy was compared between the models using the area under the receiver operating characteristic curve (AUROC), and an optimal cut-off value was determined for the most accurate model using Youden J index. The most accurate proved to be the model based on glutamate dehydrogenase activity and globulin, urea (all three positively linked with risk of chronic fascioliasis), and selenium concentration (negatively linked) adjusted by the access to pasture and cow&#8217;s age. At the optimal cut-off of 0.37 this model had sensitivity of 85.1% (CI 95%:72.3%, 92.6%), specificity of 90.4% (CI 95%:84.7%, 94.1%), positive likelihood ratio of 8.8 (CI 95%:5.4, 14.5), and negative likelihood ratio of 0.16 (CI 95%:0.08, 0.33). This model performed significantly better than model including only γ-glutamyl transpeptidase or model including both γ-glutamyl transpeptidase and aspartate aminotransferase (both also adjusted by the access to pasture and cow&#8217;s age), and was the only model which performed significantly better than the basic model based solely on the access to pasture and cow&#8217;s age.</p>
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<h4>Herd-level seroprevalence of Fasciola hepatica and Ostertagia ostertagi infection in dairy cattle population in the central and northeastern Poland</h4>
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<div>
<p class="bodytext"><a class="external-link-new-window" title="Öffnet einen externen Link in einem neuen Fenster" href="https://bmcvetres.biomedcentral.com/" target="_blank" rel="noopener noreferrer">BMC Veterinary Research 14</a>;p.131-138</p>
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<p class="bodytext"><a class="external-link-new-window" title="Öffnet einen externen Link in einem neuen Fenster" href="https://doi.org/10.1186/s12917-018-1455-7" target="_blank" rel="noopener noreferrer">https://doi.org/10.1186/s12917-018-1455-7</a></p>
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<p class="bodytext">(Sławomir J. Kowalczyk, Michał Czopowicz, Corinna N. Weber, Elisabeth Müller, Tomasz Nalbert, Andrzej Bereznowski, Jarosław Kaba)</p>
<div>
<p class="bodytext"><b>BACKGROUND:</b></p>
</div>
<div>
<p class="bodytext">Fasciola hepatica and Ostertagia ostertagi infections are widespread in cattle population of Europe, however data on their prevalence in Poland are only fragmentary. Therefore, the cross-sectional study was carried out to determine the herd-level seroprevalence of F. hepatica and O. ostertagi infection in dairy cattle population in the central and north-eastern provinces Poland, and to identify basic local risk factors for these infections. In total, 598 herds were enrolled, 394 (65.9%) in the north-eastern province and 204 (34.1%) in the central province. In each herd the questionnaire survey was conducted and bulk-tank milk (BTM) sample was collected and screened using two indirect immunoenzymatic tests. Optical density ratio (ODR) was regarded as the quantitative proxy of exposure to either of the two parasites.</p>
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<p class="bodytext"><b>RESULTS:</b></p>
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<p class="bodytext">Both Fasciola and Ostertagia ELISA ODR in the north-eastern province was significantly higher than ODR in the central province. At the cut-off value of ODR = 0.27 the true herd-level seroprevalence of F. hepatica was 79.6%(95% CI: 74.0%, 84.3%) in the north-eastern province and 13.0% (95% CI: 5.3%, 21.7%) in the central province. At the cut-off of ODR = 0.50151 of 188 herds (80.3%, 95% CI: 74.1%, 85.4%) were seropositive for O. ostertagi in the north-eastern province and only 70 of 136 herds (51.5%, 95% CI: 43.1%, 59.7%) were seropositive in the central province. Location of a herd in the north-eastern province, longer grazing period practiced in a herd and &gt; 50%-share of grazing grass in roughage were all positively related to the increase in exposure to both parasites. Moreover, the use of hay or haylage as main roughage proved to be positively related to the increase in exposure to F. hepatica.</p>
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<p class="bodytext"><b>CONCLUSIONS:</b></p>
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<p class="bodytext">F. hepatica and O. ostertagi are widespread in cattle population in Poland, however their occurrence at a herd-level varies between different regions of Poland. This diversity can only partly be explained by different herd management, and appears linked to environmental and climate conditions typical for these regions.</p>
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<h4>Serum amyloid A concentration in foals – Can it help when making a treatment decision in foals with pneumonia?</h4>
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<p class="bodytext">Pferdeheilkunde &#8211; Equine Medicine 34, p.61-67</p>
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<p class="bodytext"><a class="external-link-new-window" title="Öffnet einen externen Link in einem neuen Fenster" href="http://dx.doi.org/10.21836/PEM20180111" target="_blank" rel="noopener noreferrer">http://dx.doi.org/10.21836/PEM20180111</a></p>
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<p class="bodytext">(Thomé R, Weber C, Rohn K, Venner M)</p>
<p><b>Abstract</b></p>
<p>Bronchopneumonia is a frequent and serious pulmonary disorder in foals on equine breeding farms and the most common pathogens responsible for this condition are Streptococcus equi ssp. zooepidemicus (Strep. eq. ssp. zoo.) and Rhodococcus equi (R. equi). As foal pneumonia occurs endemically on many studs worldwide, practitioners are asked to evaluate regularly all foals in order to detect early affected foals and reduce the losses. Some of those will show neither clinical symptoms nor hematological changes but obvious pulmonary lesions at sonography. Consequently the question of treating these foals will rise. The aim of the study was to evaluate the serum amyloid A (SAA) concentration in clinically healthy or mildly sick foals showing either no findings, moderate or severe findings at lung sonography. The investigation was a prospective study. A total of 33 foals were examined once weekly starting at the age of two weeks over a period of four months. Clinical signs, body temperature, ultrasonographical pulmonary findings and haematological findings including WBC count and SAA serum concentrations were monitored. After each sonographical examination of the lung, the diameters of pulmonary consolidations were added to obtain an abscess score that represents the severity of pulmonary disease of these foals. The frozen serum samples of the 33 foals were analysed at different stages of pneumonia. Altogether, 49 samples of healthy state (abscess score=0cm), 31 of moderately sick state (abscess score=1–9cm, no indication for treatment) and 22 of severe pulmonary damage (abscess score &gt;10cm, indication for treatment) were analysed by enzyme-linked immunosorbent assay to determine the SAA concentration. The median SAA was 18µg/ml (25th percentile: 1.5µ/ml; 75th percentile: 52.7µg/ml) in the healthy foals, 5.6µg/ml (25th: 2.4µg/ml; 75th: 82.3µg/ml) in the moderately sick foals and 80.2µg/ml (25th: 79.3µg/ml; 75th: 160µg/ml) in the foals requiring treatment. These results show that the SAA concentration might be considered as an efficient parameter for making a treatment decision in foals in the early course of pneumonia.</p>
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<h4>Microbiota of the conjunctival sac of 120 healthy cats in Germany (2017)</h4>
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<p class="bodytext">Veterinary Ophthalmology; ISSN: 1463-5216</p>
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<p class="bodytext"><a class="external-link-new-window" title="Öffnet einen externen Link in einem neuen Fenster" href="http://www.ovid.com/site/catalog/journals/9910.jsp" target="_blank" rel="noopener noreferrer">http://www.ovid.com/site/catalog/journals/9910.jsp</a></p>
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<p class="bodytext">(Büttner, Jessica; Schneider, Marianne; Csokai, Jaqueline; Müller, Elisabeth; Eule, Johanna)</p>
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<h4>Report on the 4th International Symposium on Ranavirsues 2017</h4>
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<p class="bodytext">Journal of Herpetological Medicine and Surgery 28(1): 13-18</p>
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<p class="bodytext"><a class="external-link-new-window" title="Öffnet einen externen Link in einem neuen Fenster" href="https://www.researchgate.net/publication/322749286_REPORT_ON_THE_4TH_INTERNATIONAL_SYMPOSIUM_ON_RANAVIRUSES_2017" target="_blank" rel="noopener noreferrer">DOI:10.5818/17-10-131.1</a></p>
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<p class="bodytext">(Rijks JM, Saucedo B, Brunner JL, Hick P, Lesbarrères D, Duffus A, Ash LV, Marschang RE.)</p>
<p><b>Abstract</b></p>
<p>Ranaviruses are large, double-stranded DNA viruses in the family Iridoviridae. They are important pathogens in ﬁsh, amphibians, and reptiles and have caused severe disease outbreaks in captive and wild animals. Ranaviruses have been associated with population declines in amphibians in various parts of the world.</p>
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<h4>DETECTION OF OPHIDIOMYCES OPHIODIICOLA IN TWO CAPTIVE BOCOURT WATER SNAKES</h4>
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<p class="bodytext">Journal of Zoo and Wildlife Medicine 49(1):p219–222,2018</p>
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<p class="bodytext"><a class="external-link-new-window" title="Öffnet einen externen Link in einem neuen Fenster" href="http://zoowildlifejournal.com/doi/pdf/10.1638/2017-0112R.1" target="_blank" rel="noopener noreferrer">http://zoowildlifejournal.com/doi/pdf/10.1638/2017-0112R.1</a></p>
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<p class="bodytext">(Pierre Picquet, D.V.M., Kim O. Heckers, Dr. med. vet., Ekaterina Kolesnik, med. vet., Anton Heusinger, Dr. med. vet., and Rachel E. Marschang, Ph.D., Dr. med. vet., Dip. E.C.Z.M. (Herpetology)Pierre Picquet, D.V.M., Kim O. Heckers, Dr. med. vet., Ekaterina Kolesnik, med. vet., Anton Heusinger, Dr. med. vet., and Rachel E. Marschang, Ph.D., Dr. med. vet., Dip. E.C.Z.M. (Herpetology))</p>
<p><b>Abstract</b></p>
<p>Two captive Bocourt water snakes (Subsessor bocourti) presented with chronic white skin lesions on their heads; Ophidiomyces ophiodiicola was identified by culture and polymerase chain reaction (PCR) in skin scrapings from both snakes. Histopathology performed in one Bocourt water snake revealed fungal hyphae in epidermal structures of lesions. One Pueblan milk snake (Lampropeltis triangulum campbelli) from the same zoologic institution presented with yellow crusts and white blisters on its body, from which O. ophiodiicola was identified by culture and PCR. Two of the three snakes apparently recovered from lesions after multiple natural sheds, whereas the third snake died. This is the first report of O. ophiodiicola infection in Bocourt water snakes and in a Pueblan milk snake, as well as the first report of O. ophiodiicola in France.</p>
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<div id="c4615" class="csc-frame csc-frame-rulerAfter">
<h1></h1>
<blockquote>
<h4>A novel MLPH variant in dogs with coat colour dilution</h4>
</blockquote>
<div>
<p class="bodytext">Animal Genetics, Volume 49, Issue 1,p.1-4  DOI: 10.1111/age.12632</p>
</div>
<div>
<p class="bodytext"><a class="external-link-new-window" title="Öffnet einen externen Link in einem neuen Fenster" href="http://europepmc.org/abstract/med/29349785" target="_blank" rel="noopener noreferrer">http://europepmc.org/abstract/med/29349785</a></p>
</div>
<div>
<p class="bodytext">(A. Bauer, A. Kehl, V. Jagannathan, T. Leeb)</p>
<p><b>Summary</b></p>
<p>Coat colour dilution may be the result of altered melanosome transport in melanocytes. Loss-of-function variants in the melanophilin gene (MLPH) cause a recessively inherited form of coat colour dilution in many mammalian and avian species including the dog. MLPH corresponds to the D locus in many domestic animals, and recessive alleles at this locus are frequently denoted with d. In this study, we investigated dilute coloured Chow Chows whose coat colour could not be explained by their genotype at the previously known MLPH:c.–22G&gt;A variant. Whole genome sequencing of such a dilute Chow Chow revealed another variant in the MLPH gene: MLPH:c.705G&gt;C. We propose to designate the corresponding mutant alleles at these two variants d1 and d2. We performed an association study in a cohort of 15 dilute and 28 non-dilute Chow Chows. The dilute dogs were all either compound heterozygous d1/d2 or homozygous d2/d2, whereas the non-dilute dogs carried at least one wildtype allele D. The d2 allele did not occur in 417 dogs from diverse other breeds. However, when we genotyped a Sloughi family, in which a dilute coloured puppy had been born out of non-dilute parents, we again observed perfect co-segregation of the newly discovered d2 allele with coat colour dilution. Finally, we identified a blue Thai Ridgeback with the d1/d2 genotype. Thus, our data identify the MLPH:c.705G&gt;C as a variant explaining a second canine dilution allele. Although relatively rare overall, this d2 allele is segregating in at least three dog breeds, Chow Chows, Sloughis and Thai Ridgebacks.</p>
<div class="hr-thin"></div>
</div>
</div>
<div id="c4614" class="csc-default">
<h1></h1>
<blockquote>
<h1>Gastrointestinal B-lymphoblastic lymphoma in a dog:a case report</h1>
</blockquote>
<div>
<p class="bodytext">Veterinarni Medicina, 63, 2018 (01): 40–49</p>
</div>
<div>
<p class="bodytext">doi: 10.17221/114/2017-VETMED</p>
</div>
<div>
<p class="bodytext">(P. Borska, R. Husnik, P. Fictum, A. Kehl, L. Leva, M. Faldyna)</p>
<p><b>Abstract</b></p>
<p>A four-year-old Bullmastiff weighing 44 kg was presented with a 14-day history of weight loss, vomiting and diarrhoea. Abdominal ultrasonography showed the presence of abdominal lymphadenopathy and thickening of the wall of the descending colon. Esophagogastroduodenoscopy and colonoscopy with biopsy were performed. Histological examination revealed a high-grade lymphoblastic lymphoma, flow cytometric analysis detected malignant cells of the immature B phenotype. PCR for antigen receptor rearrangement confirmed IgH monoclonality pointing together with immunophenotyping to B-cell lymphoma. The dog was treated using a multi-agent chemotherapy protocol. The overall survival time was 487 days. This was an unusual case of primary gastrointestinal B-lymphoblastic lymphoma in a dog with survival equivalent to that of the multicentric form.</p>
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		<title>2017 &#124; Publications English</title>
		<link>https://laboklin.com/en/2017-publications-english/</link>
		
		<dc:creator><![CDATA[Laboklin &#124; Bad Kissingen]]></dc:creator>
		<pubDate>Wed, 20 Dec 2017 08:27:29 +0000</pubDate>
				<category><![CDATA[2017 ENG]]></category>
		<category><![CDATA[Publications English]]></category>
		<guid isPermaLink="false">https://staging.laboklin.com/int/en/?p=4266</guid>

					<description><![CDATA[- Repeatability and variability of total T4 measurements at three German veterinary laboratories
- Canine haemophilia A caused by a thymine to cytosine nucleotide exchange at nucleotide ...
- Detection of Mycoplasma spp., herpesviruses, topiviruses, and ferlaviruses...
- Detection of intranuclear coccidiosis in tortoises in Europe and China
- Immunologic responses in corn snakes
...]]></description>
										<content:encoded><![CDATA[<div class="wpb-content-wrapper"><div class="vc_row wpb_row vc_row-fluid dt-default" style="margin-top: 0px;margin-bottom: 0px"><div class="wpb_column vc_column_container vc_col-sm-12"><div class="vc_column-inner"><div class="wpb_wrapper">
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			<div id="c6686" class="csc-frame csc-frame-rulerAfter csc-space-after-25">
<blockquote>
<h4 class="csc-firstHeader">Repeatability and variability of total T4 measurements at three German veterinary laboratories</h4>
</blockquote>
<p class="bodytext">Teresa Böhm; Christoph Klinger; Janine Classen1; Laura Udraite; Monika Linek; Ralf S. Mueller<br />
Tierärztliche Praxis Kleintiere: Heft 6 2017 p. 2-7<br />
<a href="http://dx.doi.org/10.15654/TPK-161137" target="_blank" rel="noopener noreferrer">dx.doi.org/10.15654/TPK-161137</a><br />
<a href="https://tpk.schattauer.de/inhalt/archiv/issue/2555/manuscript/28107.html" target="_blank" rel="noopener noreferrer">tpk.schattauer.de/inhalt/archiv/issue/2555/manuscript/28107.html</a></p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
</div>
<div id="c4613" class="csc-frame csc-frame-rulerAfter">
<blockquote>
<h4>Canine haemophilia A caused by a thymine to cytosine nucleotide exchange at nucleotide position 6217 in a Great Dane</h4>
</blockquote>
<div>
<p class="bodytext">Berliner und Münchener Tierärztliche Wochenschrift  2017</p>
</div>
<div>
<p class="bodytext"><a class="external-link-new-window" title="Öffnet einen externen Link in einem neuen Fenster" href="https://www.researchgate.net/publication/314081923" target="_blank" rel="noopener noreferrer">https://www.researchgate.net/publication/314081923</a></p>
</div>
<div>
<p class="bodytext">DOI 10.2376/0005-9366-15121</p>
</div>
<div>
<p class="bodytext">(P. Alcaraz, A. Kehl, A. Cecil, S. Shityakov, T. Dandekar, E. Mueller, R. Mischke)</p>
<p><b>Abstract</b></p>
<p>A male Great Dane was referred to the Small Animal Clinic, University of Veteri-nary Medicine Hannover at seven months of age with a known bleeding history. The dog was diagnosed with haemophilia A (factor VIII activity: 4%). To identify the underlying genetic defect responsible for haemophilia in the patient, the coding region and exon-intron boundaries of the canine factor VIII gene were analysed by polymerase chain reaction and electrophoresis. 25 Great Danes and 25 individuals of three different breeds each served as controls. Sequence analysis of exon 21 of the canine FVIII gene of the patient showed a thymine to cytosine nucleotide exchange at nucleotide position 6217, which results in a tryptophan to arginine exchange. None of the remaining dogs studied showed the mutation. Analysis using several protein models demonstrated that the altered amino acid is located in the C1 domain of the canine FVIII protein and results in a change of the protein structure. To the knowledge of the authors, this is the first known mutation of the factor VIII gene in a Great Dane associated with haemophilia A.</p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
</div>
</div>
<div id="c4612" class="csc-frame csc-frame-rulerAfter">
<blockquote>
<h4>Detection of Mycoplasma spp., herpesviruses, topiviruses, and ferlaviruses in samples from chelonians in Europe</h4>
</blockquote>
<div>
<p class="bodytext"><a class="external-link-new-window" title="Öffnet einen externen Link in einem neuen Fenster" href="http://journals.sagepub.com/doi/pdf/10.1177/1040638717722387" target="_blank" rel="noopener noreferrer">Journal of Veterinary Diagnostic Investigation</a>, p. 1-13; 2017</p>
</div>
<div>
<p class="bodytext">doi: 10.1177/1040638717722387</p>
</div>
<div>
<p class="bodytext">(Patricia Alcaraz Rodríguez, Alexandra Kehl, Alexander Cecil, Sergey Shityakov, Thomas Dandekar, Elisabeth Mueller, Reinhard Mischke)</p>
<p><b>Abstract</b></p>
<p>We tested samples from 1,015 chelonians in Europe for Mycoplasma spp., herpesviruses, ranaviruses, picornaviruses, and ferlaviruses by PCR. Mycoplasma spp. were detected in 42.1% and herpesviruses were detected in 8.0% of tested chelonians. Differentiation of the herpesviruses revealed that 46.9% of the detected chelonian viruses were testudinid herpesvirus 1 (TeHV-1) and 54.3% were TeHV-3, including co-detections of TeHV-1 and -3 in 3 tortoises. TeHV-4 was detected in a leopard tortoise (Stigmochelys pardalis), and a herpesvirus that could not be further characterized was found in a pond slider (Trachemys scripta). Picornaviruses (topiviruses) were detected in 2.2% of the tested animals; ferlaviruses were found in 0.6%; no ranaviruses were detected in any of the animals tested. Mycoplasma spp. were detected significantly more often in Horsfield’s tortoises (Testudo horsfieldii), leopard tortoises, and Indian star tortoises (Geochelone elegans) than in other species. Horsfield’s tortoises were also significantly more often positive for TeHV-1. Mycoplasma and TeHV-1 were co-detected in 3.0%, and mycoplasma and TeHV-3 in 2.3%. The TeHV-4–positive tortoise was also positive for mycoplasma. Mycoplasma and picornaviruses were co-detected in 1.2% of the tortoises. A spur-thighed tortoise (Testudo graeca) was positive for mycoplasma and a ferlavirus. In some cases, &gt;2 pathogens were detected. A significant correlation between mycoplasma and herpesvirus detection was found. Of all tested animals, 47.6% were positive for at least one pathogen, demonstrating the importance of pathogen detection in captive chelonians.</p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
</div>
</div>
<div id="c4611" class="csc-frame csc-frame-rulerAfter">
<blockquote>
<h4>Detection of intranuclear coccidiosis in tortoises in Europe and China</h4>
</blockquote>
<div>
<p class="bodytext"><a class="external-link-new-window" title="Öffnet einen externen Link in einem neuen Fenster" href="http://zoowildlifejournal.com/loi/zamd?code=zvet-site" target="_blank" rel="noopener noreferrer">Journal of Zoo and Wildlife Medicine</a> 48(2) 2017, p.328–334</p>
</div>
<div>
<p class="bodytext">(Ekaterina Kolesnik, med.vet.,Janosch Dietz, med.vet.,Kim O. Heckers, Dr.med.vet.,and Rachel E. Marschang,P.D.Dr.med.vet.,Dipl.E.C.Z.M.(herpetology), F.T.Ä. Mikrobiologie,Z.B.Reptilien)</p>
<p><b>Abstract</b></p>
<p>Intranuclear coccidiosis of tortoises (TINC) has been described in association with systemic disease in various species of tortoises. TINC has been detected in numerous tortoises from the United States, but there are only a few reports from tropical tortoises in Germany and no reports from Asia. Using a real-time polymerase chain reaction assay, samples from 1,011 tortoises were screened for the presence of TINC. Samples originated from animals kept in captivity in Europe and in China. Coccidia were detected in a total of 27 chelonians (2.7%), including the first description of TINC in a marginated tortoise (Testudo marginata), Hermann’s tortoise (Testudo hermanni), African spurred tortoise (Centrochelys sulcata), and yellow-footed tortoise (Chelonoidis denticulatus). The highest percentage of positive animals was found in radiated tortoises (Astrochelys radiata). Although the percentage of positive animals was relatively low, this study demonstrates the global distribution of TINC in captive chelonians as well as expanding the known host range for these pathogens.</p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
</div>
</div>
<div id="c4610" class="csc-frame csc-frame-rulerAfter">
<blockquote>
<h4>Spontaneously Arising Tumours and Tumour-like Lesions of the Cervix and Uterus in 83 Pet Guinea Pigs (Cavia porcellus)</h4>
</blockquote>
<div>
<p class="bodytext"><a class="external-link-new-window" title="Öffnet einen externen Link in einem neuen Fenster" href="http://www.sciencedirect.com/science/article/pii/S0021997517300555" target="_blank" rel="noopener noreferrer">Journal of Comparative Pathology</a>, Volume 156, Issue 4, May 2017, Pages 339–351</p>
</div>
<div>
<p class="bodytext"><a class="external-link-new-window" title="Öffnet einen externen Link in einem neuen Fenster" href="https://doi.org/10.1016/j.jcpa.2017.03.002" target="_blank" rel="noopener noreferrer">https://doi.org/10.1016/j.jcpa.2017.03.002</a></p>
</div>
<div>
<p class="bodytext">(C.Laik-Schandelmaier, R.Klopfleisch, S.Schöniger, G. Weiffenbach, M. Staudacher, H.Aupperle)</p>
<p><b>Abstract</b></p>
<p>Tumours and tumour-like lesions are rare findings in the genital system of guinea pigs. The aim of the present study was to characterize nodular lesions in the cervix and uterus of guinea pigs submitted for histopathological diagnosis. Samples from 83 pet animals were investigated. Cases included 64 surgically excised masses including complete uteri (n = 37), parts from uteri containing masses (n = 8), complete masses (n = 12) or samples from masses (n = 7) and 19 complete necropsy examinations. In 55 of the cases, only solitary changes were observed; in 28 cases two or more lesions were diagnosed. Histopathological diagnoses included polyps in the vagina, cervix or uterus (n = 8), hyperplastic lesions of the endocervix (n = 10) and seven adenomas and two adenocarcinomas of the endocervix. Endometrial alterations included single small glandular cysts (n = 3), nodular glandular–cystic hyperplasia (n = 8), adenoma (n = 20) and adenocarcinoma (n = 3). Four placentas, 10 focal decidualizations and six deciduomas were found. Furthermore, 18 leiomyomas and nine leiomyosarcomas were diagnosed. Uterine malignant mixed Müllerian tumours were observed in seven cases. Overall, benign lesions outnumbered malignant tumours in the female genital tract of pet guinea pigs. Therefore, surgical excision or ovariohysterectomy should be recommended as therapy.</p>
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<p>&nbsp;</p>
</div>
</div>
<div id="c4609" class="csc-frame csc-frame-rulerAfter">
<blockquote>
<h4>Immunologic responses in corn snakes (Pantherophis guttatus) after experimentally induced infection with ferlaviruses</h4>
</blockquote>
<div>
<p class="bodytext">American Journal of Veterinary Research, 2017 Apr;78(4): p. 482-494</p>
</div>
<div>
<p class="bodytext"><a class="external-link-new-window" title="Öffnet einen externen Link in einem neuen Fenster" href="http://avmajournals.avma.org/doi/10.2460/ajvr.78.4.482" target="_blank" rel="noopener noreferrer">http://avmajournals.avma.org/doi/10.2460/ajvr.78.4.482</a></p>
</div>
<div>
<p class="bodytext">(Neul A, Schrödl W, Marschang RE, Bjick T, Truyen U, von Buttlar H, Pees M.)</p>
<div>
<p class="bodytext"><b>OBJECTIVE</b></p>
</div>
<div>
<p class="bodytext">To measure immunologic responses of snakes after experimentally induced infection with ferlaviruses.</p>
</div>
<div>
<p class="bodytext"><b>ANIMALS </b></p>
</div>
<div>
<p class="bodytext">42 adult corn snakes (Pantherophis guttatus) of both sexes.</p>
</div>
<div>
<p class="bodytext"><b>PROCEDURES </b></p>
</div>
<div>
<p class="bodytext">Snakes were inoculated intratracheally with genogroup A (n = 12), B (12), or C (12) ferlavirus (infected groups) or cell-culture supernatant (6; control group) on day 0. Three snakes from each infected group were euthanized on days 4, 16, 28, and 49, and 3 snakes from the control group were euthanized on day 49. Blood samples were collected from live snakes on days -6 (baseline), 4, 16, 28, and 49. Hematologic tests were performed and humoral responses assessed via hemagglutination-inhibition assays and ELISAs. Following euthanasia, gross pathological and histologic evaluations and virus detection were performed.</p>
</div>
<div>
<p class="bodytext"><b>RESULTS </b></p>
</div>
<div>
<p class="bodytext">Severity of clinical signs of and immunologic responses to ferlavirus infection differed among snake groups. Hematologic values, particularly WBC and monocyte counts, increased between days 4 and 16 after infection. A humoral response was identified between days 16 and 28. Serum IgM concentrations increased from baseline earlier than IgY concentrations, but the IgY relative increase was higher at the end of the study. The hemagglutination-inhibition assay revealed that the strongest reactions in all infected groups were against the strain with which they had been infected. Snakes infected with genogroup A ferlavirus had the strongest immune response, whereas those infected with genogroup B had the weakest responses.</p>
</div>
<div>
<p class="bodytext"><b>CONCLUSIONS AND CLINICAL RELEVANCE </b></p>
</div>
<div>
<p class="bodytext">Results of this experimental study suggested that the ferlavirus strain with the highest virulence induced the weakest immune response in snakes.</p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
</div>
</div>
</div>
<div id="c4608" class="csc-frame csc-frame-rulerAfter">
<blockquote>
<h4>Anti-Muellerian Hormone, inhibin A, gonadotropins and gonadotropin receptors in bull calves after partial scrotal resection, orchidectomy and Burdizzo castration</h4>
</blockquote>
<div>
<p class="bodytext">Theriogenology;january 2017,Vol. 87  <a class="external-link-new-window" title="Öffnet einen externen Link in einem neuen Fenster" href="http://dx.doi.org/10.1016/j.theriogenology.2016.08.030" target="_blank" rel="noopener noreferrer">http://dx.doi.org/10.1016/j.theriogenology.2016.08.030</a></p>
</div>
<div>
<p class="bodytext">(Dragos Scarlet, Christine Aurich, Natascha Ille, Ingrid Walter, Corinna Weber, Dagmar Pieler, Walter Peinhopf, Peter Wohlsein, Jörg Aurich)</p>
<p><b>Abstract</b></p>
<p>Eight-week-old calves were either castrated by partial scrotal resection without removing the testes (SR; n=10), Burdizzo clamp (BZ; n=10), orchidectomy (OR; n=10), or were left gonad-intact as controls (CO; n=10). Concentrations of Anti-Muellerian hormone (AMH), inhibin A, luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in plasma were determined from 16 to 48 weeks of age. At 18 months, testes of SR, BZ and CO bulls were obtained and the immunolocalization of LH and FSH receptors and AMH analysed. Concentration of AMH in plasma of CO and SR bulls decreased with increasing age (p&lt;0.001). A similar AMH profile in CO and SR indicates that SR did not induce a true cryptorchid state. In groups OR and BZ, AMH was undetectable. Plasma inhibin concentration was higher in groups CO and SR than BZ and OR (p&lt;0.001). Plasma LH and FSH concentrations decreased over time (p&lt;0.001) and were higher in groups BZ and OR than SR and CO (p&lt;0.001). In the testes, immunolabelling for AMH existed in Sertoli cells of CO and SR, but not BZ bulls. FSH receptors were localized in Sertoli cells, Leydig cells, spermatocytes and the epididymis of CO and SR animals, whereas LH receptors were restricted to Leydig cells. In BZ animals, FSH and LH receptors and AMH were absent, indicating complete testicular degeneration. In conclusion, AMH is a more reliable marker for the presence of testicular tissue in bulls than inhibin. Scrotal resection did not induce a true inguinal cryptorchid state but affected testicular responsiveness to gonadotropic stimulation.</p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
</div>
</div>
<div id="c4607" class="csc-frame csc-frame-rulerAfter">
<blockquote>
<h4>Detection of nidoviruses in live pythons and Boas</h4>
</blockquote>
<div>
<p class="bodytext">Tierärztliche Praxis Kleintiere/Heimtiere 1/2017;45 S.22-26</p>
</div>
<div>
<p class="bodytext">(Rachel E.Marschang; Ekaterina Kolesnik)</p>
</div>
<div>
<p class="bodytext"><a class="external-link-new-window" title="Öffnet einen externen Link in einem neuen Fenster" href="http://tpk.schattauer.de/fileadmin/assets/zeitschriften/tieraerztliche_praxis_k/english_version/TPK_01_2017_Marschang.pdf" target="_blank" rel="noopener noreferrer">English PDF version of the article</a></p>
<p><b>Objectives</b></p>
<p>Nidoviruses have recently been described as a putative cause of severe respiratory disease in pythons in the USA and Europe. The objective of this study was to establish the use of a conventional PCR for the detection of nidoviruses in samples from live animals and to extend the list of susceptible species. Materials and methods: A PCR targeting a portion of ORF1a of python nidoviruses was used to detect nidoviruses in diagnostic samples from live boas and pythons. A total of 95 pythons, 84 boas and 22 snakes of unknown species were included in the study. Samples tested included oral swabs and whole blood. Results: Nidoviruses were detected in 27.4% of the pythons and 2.4% of the boas tested. They were most commonly detected in ball pythons (Python [P.] regius) and Indian rock pythons (P. molurus), but were also detected for the first time in other python species, including Morelia spp. and Boa constrictor. Oral swabs were most commonly tested positive.</p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
</div>
</div>
<div id="c4606" class="csc-default">
<blockquote>
<h4>TGF-β1 serum concentrations and receptor expressions in the lens capsular of dogs with diabetes mellitus</h4>
</blockquote>
<div>
<p class="bodytext"><a class="external-link-new-window" title="Öffnet einen externen Link in einem neuen Fenster" href="http://www.openveterinaryjournal.com/" target="_blank" rel="noopener noreferrer">Open Veterinary Journal</a>, (2017), Vol. 7(1): 12-15,  <a class="external-link-new-window" title="Startet den Datei-Download" href="http://www.openveterinaryjournal.com/2017/Volume 7 No 1/OVJ-121-05-16 S. Neumann et al.pdf" target="_blank" rel="noopener noreferrer">PDF</a></p>
</div>
<div>
<p class="bodytext">(Stephan Neumann, Jens Linek, Gerhard Loesenbeck, Julia Schüttler and Sonja Gaedke)</p>
<p><b>Abstract</b></p>
<p>Tissue fibrosis as complication of diabetes mellitus is known in humans. Because TGF-β1induces fibrosis and is elevated in humans suffering from diabetes mellitus we measured this growth factor in serum of dogs with diabetes mellitus and compared it with healthy dogs and those with fibrotic diseases. Further we measured the expression of TGF-β1receptor on lens capsule to investigate possible association between diabetes mellitus and cataract associated alterations. TGF-β1 was measured in serum of 12 dogs with diabetes mellitus, 20 healthy controls and 12 dogs with fibrotic diseases. Dogs with diabetes mellitus and fibrotic diseases have significantly increased TGF-β1 serum concentrations compared to healthy controls. Some dogs with diabetes mellitus showed increased expression of TGF-β1 receptor in lens capsule. Based on our observations we can conclude that TGF-β1 elevation in dogs with diabetes mellitus may induces complications of the disease and may participates on lens alteration.</p>
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		<title>2016 &#124; Publications English</title>
		<link>https://laboklin.com/en/2016-publications-english/</link>
		
		<dc:creator><![CDATA[Laboklin &#124; Bad Kissingen]]></dc:creator>
		<pubDate>Wed, 21 Dec 2016 10:29:38 +0000</pubDate>
				<category><![CDATA[2016 ENG]]></category>
		<category><![CDATA[Publications English]]></category>
		<guid isPermaLink="false">https://staging.laboklin.com/int/en/?p=1306413</guid>

					<description><![CDATA[- Cutaneous and Subcutaneous Soft Tissue Tumours in Snakes: A Retrospective Study of 33 Cases
- Virus distribution and detection in corn snakes ...
- Detection of nidoviruses in live pythons and boas
- Repeated detection of an invertebrate iridovirus (IIV) in amphibians
- High prevalence of intestinal adenocarcinoma in a captive population of Amazon milk frog
...]]></description>
										<content:encoded><![CDATA[<div class="wpb-content-wrapper"><div class="vc_row wpb_row vc_row-fluid dt-default" style="margin-top: 0px;margin-bottom: 0px"><div class="wpb_column vc_column_container vc_col-sm-12"><div class="vc_column-inner"><div class="wpb_wrapper">
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			<div id="c6701" class="csc-frame csc-frame-rulerAfter csc-space-after-25">
<blockquote>
<h4 class="csc-firstHeader">Cutaneous and Subcutaneous Soft Tissue Tumours in Snakes: A Retrospective Study of 33 Cases</h4>
</blockquote>
<p class="bodytext">J. Dietz, K. O. Heckers, H. Aupperle and M. Pees<br />
Journal of Comparative Pathology, 155 (2016) p.76-87</p>
<p><a href="http://www.sciencedirect.com/science/journal/00219975" target="_blank" rel="noopener">www.sciencedirect.com/science/journal/00219975</a></p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
</div>
<div id="c6689" class="csc-frame csc-frame-rulerAfter csc-space-after-25">
<blockquote>
<h4>Virus distribution and detection in corn snakes (Pantherophis guttatus) after experimental infection with three different ferlavirus strains</h4>
</blockquote>
<p class="bodytext">Pees M, Neul A, Müller K, Schmidt V, Truyen U, Leineceker N, Marschang RE.<br />
Vet Mircrobiol 182 p. 213-322<br />
doi:10.1016/j.vetmic.2015.11.024.</p>
<p><a href="http://www.elsevier.com/" target="_blank" rel="noopener">www.elsevier.com</a></p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
</div>
<div id="c4605" class="csc-frame csc-frame-rulerAfter">
<blockquote>
<h4>Detection of nidoviruses in live pythons and boas</h4>
</blockquote>
<div>
<p class="bodytext"><a class="external-link-new-window" title="Öffnet einen externen Link in einem neuen Fenster" href="https://tpk.schattauer.de/inhalt/archiv/issue/2453/manuscript/26682.html" target="_blank" rel="noopener">Tierarztl Prax, Kleintiere Heimtiere.</a> 44(6): <a class="download" title="Startet den Datei-Download" href="https://laboklin.com/fileadmin/FILES/Downloads/Publikationen/english/2016/TPK_01_2017_Marschang.pdf">PDF</a>   doi: 10.15654/TPK-151067</p>
</div>
<div>
<p class="bodytext">(Marschang RE, Kolesnik E.)</p>
<div>
<p class="bodytext"><b>OBJECTIVES:</b></p>
</div>
<div>
<p class="bodytext">Nidoviruses have recently been described as a putative cause of severe respiratory disease in pythons in the USA and Europe. The objective of this study was to establish the use of a conventional PCR for the detection of nidoviruses in samples from live animals and to extend the list of susceptible species.</p>
</div>
<div>
<p class="bodytext"><b>MATERIALS AND METHODS:</b></p>
</div>
<div>
<p class="bodytext">A PCR targeting a portion of ORF1a of python nidoviruses was used to detect nidoviruses in diagnostic samples from live boas and pythons. A total of 95 pythons, 84 boas and 22 snakes of unknown species were included in the study. Samples tested included oral swabs and whole blood.</p>
</div>
<div>
<p class="bodytext"><b>RESULTS:</b></p>
</div>
<div>
<p class="bodytext">Nidoviruses were detected in 27.4% of the pythons and 2.4% of the boas tested. They were most commonly detected in ball pythons (Python [P.] regius) and Indian rock pythons (P. molurus), but were also detected for the first time in other python species, including Morelia spp. and Boa constrictor. Oral swabs were most commonly tested positive.</p>
</div>
<div>
<p class="bodytext"><b>CONCLUSION:</b></p>
</div>
<div>
<p class="bodytext">The PCR described here can be used for the detection of nidoviruses in oral swabs from live snakes. These viruses appear to be relatively common among snakes in captivity in Europe and screening for these viruses should be considered in the clinical work-up.</p>
</div>
<div>
<p class="bodytext"><b>CLINICAL RELEVANCE:</b></p>
</div>
<div>
<p class="bodytext">Nidoviruses are believed to be an important cause of respiratory disease in pythons, but can also infect boas. Detection of these viruses in live animals is now possible and can be of interest both in diseased animals as well as in quarantine situations.</p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
</div>
</div>
</div>
<div id="c4604" class="csc-frame csc-frame-rulerAfter">
<blockquote>
<h4>Repeated detection of an invertebrate iridovirus (IIV) in amphibians</h4>
</blockquote>
<div>
<p class="bodytext">Journal of Herpetological Medicine and Surgery 26:P.54-58.</p>
</div>
<div>
<p class="bodytext">doi: <a class="external-link-new-window" title="Öffnet einen externen Link in einem neuen Fenster" href="http://dx.doi.org/10.5818/15-03-041.1" target="_blank" rel="noopener">http://dx.doi.org/10.5818/15-03-041.1</a></p>
</div>
<div>
<p class="bodytext">(Stöhr AC, Papp T, Marschang RE)</p>
<p><b>Abstract</b></p>
<div>
<p class="bodytext">Invertebrate iridoviruses (IIVs) (family: Iridoviridae) are known pathogens for invertebrates causing high mortality and reduced fertility in affected insects. During the last years, IIVs have also been increasingly found in lizards in association with nonspecific clinical signs. It has been hypothesized that IIVs from insects are able to infect reptiles.</p>
</div>
<div></div>
<div>
<p class="bodytext">In the years 2010-2011, IIVs were repeatedly detected via PCR and virus isolation methods in routine diagnostic samples from different amphibians: three blue poison dart frogs (Dendrobates tinctorius azureus), four edible frogs (Pelophylax kl. esculentus), a giant ditch frog (Leptodactylus fallax), an Amazon milk frog (Trachycephalus resinifictrix), mixed organs from agile frogs (Rana dalmatina), a black-spined toad (Bufo melanostictus), and one Lake Urmia newt (Neurergus crocatus). IIVs were found in skin swabs from apparently healthy animals, as well as in multiple organs of frogs that died of unknown causes. Prey insects (crickets) from one owner also tested positive for the presence of IIV. The obtained partial sequences from the major capsid protein (MCP) gene (222nt) from each of these were 100% identical to each other and 98% identical to IIV-6, the type species of the genus Iridovirus. Although the pathogenicity of IIV in amphibians remains unclear, these findings provide further evidence that IIVs may be able to infect vertebrates under some conditions and underline the importance of the genus Iridovirus in vertebrates.</p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
</div>
</div>
</div>
<div id="c4603" class="csc-frame csc-frame-rulerAfter">
<blockquote>
<h4>High prevalence of intestinal adenocarcinoma in a captive population of Amazon milk frog (Trachycephalus resinifictrix)</h4>
</blockquote>
<div>
<p class="bodytext">Journal of Zoo and Wildlife Medicine 2016 Dec;47(4):1061-1068.  <a class="external-link-new-window" title="Öffnet einen externen Link in einem neuen Fenster" href="http://www.bioone.org/doi/pdf/10.1638/2016-0037.1" target="_blank" rel="noopener">doi: 10.1638/2016-0037.1</a></p>
</div>
<div>
<p class="bodytext">(López J, Barbón AR, Smithyman J, Goetz M, Marschang RE, Dastjerdi A, Stidworthy MF)</p>
<p><b>Abstract</b></p>
<p>A series of eight cases of intestinal adenocarcinoma in Amazon milk frog (Trachycephalus resinifictrix) is described. All cases presented with signs of inappetence and weight loss, and evidence of large intestinal distention on gross postmortem, with six of the eight cases showing a grossly visible large intestinal mass. Histologic examination identified the mass as an intestinal adenocarcinoma in all cases. No specific etiologic agent could be identified. This is the first report of neoplasia in the Amazon milk frog, and the first reported series of amphibian gastrointestinal neoplasia.</p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
</div>
</div>
<div id="c4602" class="csc-frame csc-frame-rulerAfter">
<blockquote>
<h4>Detection of testudinid herpesvirus type 4 in a leopard tortoise (Stigmochelys pardalis)</h4>
</blockquote>
<div>
<p class="bodytext">Tierarztl Prax, Kleintiere Heimtiere. 2016 Aug 17;44(4):p. 283-6. <a class="external-link-new-window" title="Öffnet einen externen Link in einem neuen Fenster" href="https://tpk.schattauer.de/inhalt/archiv/issue/2389/manuscript/25965.html" target="_blank" rel="noopener">doi: 10.15654/TPK-150843</a></p>
</div>
<div>
<p class="bodytext">(Kolesnik E, Mittenzwei F, Marschang RE)</p>
<p><b>Abstract</b></p>
<p>Several animals from a mixed species collection of tortoises in Germany died unexpectedly. Some of the affected leopard tortoises (Stigmochelys pardalis) from this group showed respiratory signs. Samples were collected from one of the ill tortoises, and a Mycoplasma spp. and a herpesvirus were detected by PCR. Sequencing of a portion of the DNA polymerase gene of the herpesvirus showed 99% identity with testudinid herpesvirus 4, previously described only once in a bowsprit tortoise (Chersina angulata) in the United States.</p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
</div>
</div>
<div id="c4601" class="csc-frame csc-frame-rulerAfter">
<blockquote>
<h4>Viral diseases of reptiles</h4>
</blockquote>
<div>
<p class="bodytext">In Practice. 38(6):p. 275–385, JUN 2016   <a class="external-link-new-window" title="Öffnet einen externen Link in einem neuen Fenster" href="http://journals.sagepub.com/doi/pdf/10.1177/1040638716628584" target="_blank" rel="noopener">DOI: 10.1177/1040638716628584</a></p>
</div>
<div>
<p class="bodytext">(Rachel E. Marschang)</p>
<p><b>Abstract</b></p>
<p>As reptile medicine has grown and more is known about various diseases in these animals, the importance of some viruses in clinical reptile practice has become more widely understood. More and more studies have become available on the prevalence of infections with specific viruses in different reptiles, as well as clinical signs associated with these infections. An increasing body of knowledge on the genomes of specific viruses is available, which has also led to the development of more sensitive and more specific testing methods. The availability of new, high-throughput sequencing methods has allowed the detection of previously unknown viruses that are associated with specific disease syndromes in the tissues of reptiles. All of this has led to a much expanded pallet of diagnostic tests available to practitioners, while knowledge of the interpretation of results may, in many cases, have lagged behind. This article describes some important viruses in reptiles that may be commonly seen in private practice, and how to diagnose them.</p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
</div>
</div>
<div id="c4600" class="csc-frame csc-frame-rulerAfter">
<blockquote>
<h4>Development of a consensus reverse transcription polymerase chain reaction assay for the specific detection of tortoise picornaviruses</h4>
</blockquote>
<p class="bodytext">J Vet Diagn Invest. 28: P.309-314.  <a class="external-link-new-window" title="Öffnet einen externen Link in einem neuen Fenster" href="http://dx.doi.org/10.1136/inp.i2719" target="_blank" rel="noopener">http://dx.doi.org/10.1136/inp.i2719</a></p>
<p>(Marschang RE)</p>
<p><b>Abstract</b></p>
<p>Picornaviruses (PVs) of different terrestrial tortoise species, previously designated as Virus &#8220;X,&#8221; have been frequently detected from various tissues by virus isolation in Terrapene heart cell culture as the preferred laboratory method for diagnosis. Here, we describe the development of 2 diagnostic reverse transcription (RT)-PCR-based assays for the identification and characterization of tortoise PVs belonging to the tentative genus Topivirus To test the novel diagnostic systems, PVs were isolated from swab and tissue samples collected in Germany, Italy, and Hungary between 2000 and 2013. All 25 tested isolates gave positive results with both novel consensus primer sets. Sequencing of the amplified products confirmed that all studied viruses were members of the new proposed genus Topivirus Phylogenetic analyses clearly distinguished 2 lineages within the genus. Based on sequence analysis, no association was observed between the geographic distribution and genetic relatedness. Furthermore, no strict host specificity was indicated. The PCR-based diagnosis may provide a time-saving and sensitive method to detect tortoise PVs, and evaluation of PV presence in these animals may help control virus spread.</p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
</div>
<div id="c4599" class="csc-frame csc-frame-rulerAfter">
<blockquote>
<h4>Usefulness of serum cardiac troponin I concentration as a marker of survival of harbor seal (Phoca vitulina) pups during rehabilitation</h4>
</blockquote>
<div>
<p class="bodytext"><a class="external-link-new-window" title="Öffnet einen externen Link in einem neuen Fenster" href="http://avmajournals.avma.org/doi/10.2460/javma.249.12.1428" target="_blank" rel="noopener">Journal of the American Veterinary Medical Association</a> ;Volume 249; Band 12,p.1428 &#8211; 1435</p>
</div>
<div>
<p class="bodytext">(Sonja Fonfara, Janne Sundermeyer, Domingo Casamian Sorrosal, Corinna Weber, Tanja Rosenberger)</p>
</div>
<div>
<div>
<p class="bodytext"><b>OBJECTIVE</b></p>
</div>
<div>
<p class="bodytext">To measure serum cardiac troponin I (cTnI) concentrations in orphaned harbor seal (Phoca vitulina) pups at various points during rehabilitation in a seal rescue center and determine whether cTnI concentration was associated with survival during rehabilitation and duration of rehabilitation.</p>
</div>
<div>
<p class="bodytext"><b>DESIGN </b></p>
</div>
<div>
<p class="bodytext">Serial cross-sectional study.</p>
</div>
<div>
<p class="bodytext"><b>ANIMALS </b></p>
</div>
<div>
<p class="bodytext">Fifty-five 2- to 9-day-old harbor seal pups.</p>
</div>
<div>
<p class="bodytext"><b>PROCEDURES </b></p>
</div>
<div>
<p class="bodytext">Blood samples for serum cTnI concentration measurement, CBC, and serum biochemical analysis were obtained from seal pups at admission into a seal rescue center, after 2 weeks of rehabilitation at the center, and prior to release. Serum cTnI concentrations were compared between seals that did or did not survive rehabilitation.</p>
</div>
<div>
<p class="bodytext"><b>RESULTS </b></p>
</div>
<div>
<p class="bodytext">Median serum cTnI concentration was highest at admission (0.03 ng/mL). After 2 weeks, the median value was 0.01 ng/mL; prior to release, it was 0.01 ng/mL. Seal pups that were found to have died during or after rehabilitation (n = 7) had a significantly higher median serum cTnI concentration at admission (0.06 ng/mL) than did seal pups that survived rehabilitation (and for which the postrelease fate was unknown; 48; 0.03 ng/mL). No correlation was identified between serum cTnI concentration and duration of rehabilitation.</p>
</div>
<div>
<p class="bodytext"><b>CONCLUSIONS AND CLINICAL RELEVANCE </b></p>
</div>
<div>
<p class="bodytext">The results of this study suggested some degree of myocardial injury was present in most of the orphaned seal pups admitted for rehabilitation. Measurement of serum cTnI concentration in seal pups at admission might provide prognostic information about their likelihood of survival during or after rehabilitation.</p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
</div>
</div>
</div>
<div id="c4598" class="csc-frame csc-frame-rulerAfter">
<blockquote>
<h4>Herd-level seroprevalence of Neospora caninum infection in dairy cattle in central and northeastern Poland</h4>
</blockquote>
<div>
<p class="bodytext">Acta Parasitol. 2016 Jan;61(1):p. 63-65   <a class="external-link-new-window" title="Öffnet einen externen Link in einem neuen Fenster" href="https://doi.org/10.1515/ap-2016-0006" target="_blank" rel="noopener">https://doi.org/10.1515/ap-2016-0006</a></p>
</div>
<div>
<p class="bodytext">J. Kowalczyk, Michał Czopowicz, Corinna N. Weber, Elisabeth Müller, Lucjan Witkowski and Jarosław Kaba(Sławomir)</p>
<p><b>Abstract</b></p>
<p>A serosurvey was carried out to estimate the herd-level seroprevalence of Neospora caninum infection in cattle in central and northeastern Poland. Ninety seven dairy cattle herds from 2 provinces of Poland (Podlaskie, 47 herds and Łodzkie, 50 herds) were randomly enrolled in the study using two-stage cluster method. A simple random selection was applied within each herd to select a sample of adult cows (≥18 month-old). A total number of 734 cows were enrolled in the study. The animals were screened with a commercial competitive ELISA (Bio-X Diagnostics, Belgium). To calculate true herd-level seroprevalence test sensitivity and specificity were adjusted from an individual- to a herd-level using FreeCalc method. The true overall herd-level seroprevalence of N. caninum infection was 56.7% (95% CI: 47.5%, 65.9%). The true herd-level seroprevalence in Podlaskie was 63.3% (95% CI: 43.0%, 83.6%) and 50.5% (95% CI: 32.8%, 68.2%) in Łodzkie province and these figures did not differ significantly between the two provinces (chi2 test p = 0.238). One hundred forty three of 734 cows (19.5%) were seropositive which gave the true overall individual-level seroprevalence of 20.1% (95% CI: 17.4%, 23.2%). Percentage of seropositive cows in each herd varied from 6% to 80%. This study is the first epidemiological investigation of herd-level seroprevalence of N. caninum infection in Polish dairy cattle population. In conclusion, the result of the study confirmed previous data that N. caninum infection is widespread in the Polish cattle population and thus should be considered as a potential cause of spontaneous abortions.</p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
</div>
</div>
<div id="c4597" class="csc-frame csc-frame-rulerAfter">
<blockquote>
<h4>Polypoid hypertrophic gastropathia similar to human Morbus Ménétrier-Disease in the pars pylorica of a warmblood-mixgelding</h4>
</blockquote>
<div>
<p class="bodytext"><a class="external-link-new-window" title="Öffnet einen externen Link in einem neuen Fenster" href="http://www.pferdeheilkunde.de/" target="_blank" rel="noopener">Pferdeheilkunde</a> 32 (2016) p. 606-610</p>
</div>
<div>
<p class="bodytext">(Rapp S.; Aupperle H.)</p>
<p><b>Language</b>: German</p>
<p><b>Summary</b></p>
<p>A 12-year-old warmblood-mix gelding showed clinical signs of poor feed intake and decreased performance. Additionally cough was des-cribed. Therefore the gelding was first treated against chronic bronchitis. The cough disappeared but clinical signs of weight loss and poorfeed intake prolonged. That was the reason why an endoscopic examination of the stomach was performed. First endoscopy showed a largeconcretion of feed material. A visualization of the pars glandularis and the pars non-glandularis as well as the pylorus was not possible. Therefore a laxative therapy with paraffin and Glauber solution over a nasogastric tube was initiated. The endoscopic examination of thestomach could be done on the third day. Abnormal radially arranged mucosal growths on the pars pylorica ensured that polyps were seen.The margo plicatus also showed ulcera (ESGD 3/4). The horse was treated with omeprazole and metoclopramide for six weeks. After that,a second endoscopic examination of the stomach was performed. As well as the ulcera on the margo plicatus as the gastric polyps of thepars pylorica showed no improvement. Another period of treatment should start for about two months of duration. In that time, the geldingshould be kept on pasture during the day and get on shavings over the night. Next to gras, soaked cobs of hay should be offered for feed.Ten days later, the gelding showed acute signs of colic at home. The condition of the horse was getting bad so the decision for surgery wasmade. During the laparotomy under general anesthesia some incarcerated small intestine due to a hernia foraminis omentalis was detected.The owner did not give the permission for resection (3m), so the gelding was euthanized during surgery. After that a transmural biopsy wastaken from the region of the pars pylorica due to scientific interests. A post-mortem examination was not desired by the owner. The tissuesample was fixed in 4% formalin and sent for histological examination. Here a diffuse polypoid hypertrophic gastropathy (Morbus Ménétrier)was diagnosed. Main characteristics were the markedly elongated foveolae gastricae of the hyperplastic gastric mucosa without any signs ofmalignancy. Helicobacter sp. was not found in the pathological examination. So far the Morbus Ménétrier was not described in a horse yet.</p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
</div>
</div>
<div id="c4596" class="csc-frame csc-frame-rulerAfter">
<blockquote>
<h4>Triple infection with agamid adenovirus 1, Encephaliton cuniculi-like microsporidium and enteric coccidia in a bearded dragon (Pogona vitticeps)</h4>
</blockquote>
<div>
<p class="bodytext"><a class="external-link-new-window" title="Öffnet einen externen Link in einem neuen Fenster" href="http://tpk.schattauer.de/inhalt/archiv/issue/2411/manuscript/26046.html" target="_blank" rel="noopener">Tierärztliche Praxis Kleintiere</a> 2016: Heft 5, S.355-358</p>
</div>
<div>
<p class="bodytext"><a class="external-link-new-window" title="Öffnet einen externen Link in einem neuen Fenster" href="http://dx.doi.org/10.15654/TPK-150790" target="_blank" rel="noopener">http://dx.doi.org/10.15654/TPK-150790 </a></p>
</div>
<div></div>
<div>
<p class="bodytext">(Lionel Schilliger; Véronique Mentré; Rachel E. Marschang; Alexandra Nicolier; Barbara Richter)</p>
<p><b>Summary</b></p>
<div>
<p class="bodytext">A 2-month-old juvenile central bearded dragon was presented for anorexia and cachexia. Another specimen from the same cage had died suddenly 2 weeks prior. Fecal analysis revealed a high quantity of Isospora amphiboluri and a few pinworm eggs. Other examinations were not performed and the animal died a few days later despite supportive care. A third individual from the same cage presented with anorexia and a distended coelom and was euthanized. In this third dragon, histological examination revealed intestinal coccidiosis, basophilic intranuclear inclusions compatible with adenovirus infection, acute hepatic necrosis with intrahepatocytic and intraenteritic organisms typical of microsporidia and renal gout.</p>
</div>
<div>
<p class="bodytext">A PCR confirmed the diagnosis of adenovirosis. Sequencing showed that the PCR product was 100% identical to the corresponding portion of the agamid adenovirus 1 genome. A PCR for the detection of Encephalitozoon (E.) cuniculi was positive. Partial sequencing revealed 100% identity to an E. cuniculi-like organism previously found in bearded dragons. In cases where environmental factors such as poor hygiene or stress can be excluded, the presence of opportunistic pathogens in high numbers can be due to a systemic (viral) infection with temporary immunosuppression.</p>
<p><a class="download" title="Startet den Datei-Download" href="https://laboklin.com/fileadmin/FILES/Downloads/Publikationen/english/2016/TPK_5_2016_Schilliger.pdf" target="_blank" rel="noopener">PDF Download &gt;&gt;</a></p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
</div>
</div>
</div>
<div id="c4595" class="csc-frame csc-frame-rulerAfter">
<blockquote>
<h4>What do the values really mean? &#8211; A comparison of an enzyme-linked fluorescent assay vs chemiluminescent immunoassay for measuring serum progesterone in bitches</h4>
</blockquote>
<div>
<p class="bodytext">Proceedings of the 8th International Symposium on Canine and Feline Reproduction ISCFR 2016, Paris, P.223 <a class="external-link-new-window" title="Öffnet einen externen Link in einem neuen Fenster" href="http://www.ivis.org/" target="_blank" rel="noopener">www.ivis.org</a></p>
</div>
<div>
<p class="bodytext">(Jenny Uhlmann, Corinna Weber, Uwe Kuechenmeister, Andrea Muennich)</p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
</div>
</div>
<div id="c4594" class="csc-frame csc-frame-rulerAfter">
<blockquote>
<h4>Cutaneous and Subcutaneous Soft Tissue Tumours in Snakes: A Retrospective Study of 33 Cases</h4>
</blockquote>
<div>
<p class="bodytext">Journal of Comparative Pathology, 155 (2016) 76-87.  <a class="external-link-new-window" title="Öffnet einen externen Link in einem neuen Fenster" href="http://www.sciencedirect.com/science/journal/00219975" target="_blank" rel="noopener">doi:10.1016/j.jcpa.2016.05.009</a></p>
</div>
<div>
<p class="bodytext">(J. Dietz, K. O. Heckers, H. Aupperle and M. Pees)</p>
<p><b>Summary</b></p>
<p>Cutaneous and subcutaneous soft tissue tumours have been rarely described in detail in snakes. Several malignant entities show strikingly similar histological patterns and therefore the term soft tissue sarcoma (STS) has become a standard histopathological diagnosis. The present study characterizes soft tissue tumours in 33 snakes. Samples included 29 surgically excised masses and four carcasses. Additionally, six animals were humanely destroyed and submitted for necropsy examination following tumour recurrence. Benign neoplasms (n = 8) were described as lipomas of varying differentiation. Recurrence was observed in two of five snakes in which the clinical course was recorded. Malignant neoplasms (n = 25) were diagnosed as STS and graded according to a three-point system previously applied to canine STS. Five (20%) of the primary tumours were classified as grade 1, eleven (44%) as grade 2 and nine (36%) as grade 3 sarcomas. Clinically, recurrence of STS was observed in 11 of 17 cases with available follow-up information. Pathologically, multiple cutaneous metastases were found in one grass snake (Natrix natrix), while visceral metastases were observed in one carpet python (Morelia spilota) and two corn snakes (Pantherophis guttatus). Metastatic risk appears to increase with histological grade. Surgical excision generally represents the current therapy of choice for STS. This study includes the first reports of conventional lipomas in a ribbon snake (Thamnophis radix), angiolipomas in a black-headed python (Aspidites melanocephalus) and a corn snake as well as of STS in a Jamaican boa (Epicrates subflavus), emerald tree boa (Corallus caninus), grass snake (N. natrix), African house snake (Lamprophis fuliginosus), California kingsnake (Lampropeltis getula californiae) and common garter snake (Thamnophis sirtalis).</p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
</div>
</div>
<div id="c4593" class="csc-frame csc-frame-rulerAfter">
<blockquote>
<h4>Whole genome characterization of a chelonian orthoreovirus strain identifies significant genetic diversity and may classify reptile orthoreoviruses into distinct species</h4>
</blockquote>
<div>
<p class="bodytext">Virus Research, Volume 215, 2 April 2016, Pages 94–98. <a class="external-link-new-window" title="Öffnet einen externen Link in einem neuen Fenster" href="http://www.sciencedirect.com/science/article/pii/S0168170216301149" target="_blank" rel="noopener">ELSEVIER</a></p>
</div>
<div>
<p class="bodytext">(Kugler R, Marschang RE, Ihász K, Lengyel G, Jakab F, Bányai K, Farkas S.)</p>
<p><b>Abstract</b></p>
<p>In this study we report the sequence and phylogenetic characterization of an orthoreovirus strain, CH1197/96, isolated from a spur-thighed tortoise (Testudo graeca) on chicken embryo fibroblast cells. The 23,957bp long genome sequence was obtained by combined use of semiconductor and capillary sequencing. Although the genomic characterization showed that the virus was most similar to the bush viper reovirus strain, 47/02, and in phylogenies performed with all segments the two strains formed a monophyletic group, the nucleotide (48.4-70.3%) and amino acid (39.2-80.7%) sequence identity values were moderate between the two reptile origin reoviruses. Based on our results and existing classification criteria for the genus Orthoreovirus, the tortoise reovirus strain CH1197/96 might be the first representative of a novel reptilian origin Orthoreovirus species.</p>
<div class="hr-thin"></div>
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<div id="c4592" class="csc-default">
<blockquote>
<h4>Virus distribution and detection in corn snakes (Pantherophis guttatus) after experimental infection with three different ferlavirus strains</h4>
</blockquote>
<div>
<p class="bodytext">Vet Mircrobiol 182, 2016: p.213-222.   <a class="external-link-new-window" title="Öffnet einen externen Link in einem neuen Fenster" href="http://www.ncbi.nlm.nih.gov/pubmed/26711050" target="_blank" rel="noopener">doi:10.1016/j.vetmic.2015.11.024</a>.</p>
</div>
<div>
<p class="bodytext">(Pees M, Neul A, Müller K, Schmidt V, Truyen U, Leineceker N, Marschang RE)</p>
<p><b>Abstract</b></p>
<p>Ferlaviruses are important pathogens of snakes. However, factors influencing the pathogenicity of individual isolates as well as optimal protocols for virus detection in tissues of infected snakes have been insufficiently studied. The objectives of this study were to compare virus detection using previously described PCR and cell culture protocols following infection with three genetically distinct ferlaviruses in corn snakes (Pantherophis guttatus) as a model species. Groups of 12 corn snakes were each inoculated intratracheally with a genogroup A, B, or C ferlavirus. Tracheal washes and cloacal swabs were tested for virus shedding on days 16 and 28. Three animals were each euthanized on days 4, 16, 28, and 49. Beside immunohistochemistry of lung tissue, several organs (lung, intestine, pancreas, kidney, brain) were tested for the presence of ferlavirus. Distinct differences were noted in the pathogenicity of the three viruses, with a genotype B isolate causing the greatest pathology. PCR was more sensitive in comparison to cell culture, but results varied depending on the tissues. Ferlaviruses spread rapidly into the tissues, including the brain. Overall average detection rate was 72%, and was highest on day 16. There were differences between the groups, with the most virulent strain causing 100% positive samples at the end of the study. Some snakes were able to clear the infection. Shedding via cloaca was seen only on day 28. For ante-mortem sampling, a tracheal wash sample is recommended, for post mortem diagnosis, a pooled organ sample should be tested.</p>
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		<title>2015 &#124; Publications English</title>
		<link>https://laboklin.com/en/2015-publications-english/</link>
		
		<dc:creator><![CDATA[Laboklin &#124; Bad Kissingen]]></dc:creator>
		<pubDate>Tue, 22 Dec 2015 10:30:06 +0000</pubDate>
				<category><![CDATA[2015]]></category>
		<category><![CDATA[Publications English]]></category>
		<guid isPermaLink="false">https://staging-wp-int.laboklin.com/?p=1440869</guid>

					<description><![CDATA[- The role of cortisol in chronic binge alcohol-induced cerebellar injury
- Phylogeny and Differentiation of Reptilian and Amphibian Ranaviruses Detected in Europe
- Kinetics of local and systemic leucocyte and cytokine reaction of calves to intrabronchial infection with Chlamydia psittaci
- Development of a multiplex fluorescence immunological assay for the simultaneous detection of ...
- Detection of feline coronavirus spike gene mutations as a tool to diagnose feline infectious peritonitis
...]]></description>
										<content:encoded><![CDATA[<div class="wpb-content-wrapper"><div class="vc_row wpb_row vc_row-fluid dt-default" style="margin-top: 0px;margin-bottom: 0px"><div class="wpb_column vc_column_container vc_col-sm-12"><div class="vc_column-inner"><div class="wpb_wrapper">
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<blockquote>
<h4 class="csc-firstHeader">The role of cortisol in chronic binge alcohol-induced cerebellar injury: Ovine model</h4>
</blockquote>
<p class="bodytext">Washburn SE, Tress U, Lunde ER, Chen WJ, Cudd TA<br />
Alcohol. 2013 February;47(1)</p>
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<p>&nbsp;</p>
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<div id="c6711" class="csc-frame csc-frame-rulerAfter csc-space-after-25">
<blockquote>
<h4>Phylogeny and Differentiation of Reptilian and Amphibian Ranaviruses Detected in Europe</h4>
</blockquote>
<p class="bodytext">Anke C. Stöhr,Alberto López-Bueno,Silvia Blahak,Maria F. Caeiro,Gonçalo M. Rosa,António Pedro Alves de Matos,An Martel,Alí Alejo,Rachel E. Marschang<br />
PLOS ONE,  February 23, 2015 p. 1-24<br />
<a href="https://doi.org/10.1371/journal.pone.0118633" target="_blank" rel="noopener">doi.org/10.1371/journal.pone.0118633</a></p>
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<div id="c4591" class="csc-frame csc-frame-rulerAfter">
<blockquote>
<h4>Kinetics of local and systemic leucocyte and cytokine reaction of calves to intrabronchial infection with Chlamydia psittaci</h4>
</blockquote>
<div>
<p class="bodytext">PLOS One; Volume 10, Band 8, p.1-21   <a class="external-link-new-window" title="Öffnet einen externen Link in einem neuen Fenster" href="https://doi.org/10.1371/journal.pone.0135161" target="_blank" rel="noopener">https://doi.org/10.1371/journal.pone.0135161</a></p>
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<p class="bodytext">(Annette Prohl, Katharina Wolf, Corinna Weber, Elisabeth Müller, Christian Menge, Konrad Sachse, Juergen Roedel, Petra Reinhold, Angela Berndt)</p>
<p><b>Abstract<br />
</b><br />
Infection of cattle with chlamydiae is ubiquitous and, even in the absence of clinical sequeleae, has a quantifiable negative impact on livestock productivity. Despite recent progress, our knowledge about immune response mechanisms capable of counteracting the infection and preventing its detrimental effects is still limited. A well-established model of bovine acute respiratory Chlamydia (C.) psittaci infection was used here to characterize the kinetics of the local and systemic immune reactions in calves. In the course of two weeks following inoculation, leukocyte surface marker expression was monitored by flow cytometry in blood and bronchoalveolar lavage fluid (BALF). Immune-related protein and receptor transcription were determined by quantitative real-time reverse transcription PCR in blood, BALF and lung tissue. An early increase of IL2RA, IL10 and HSPA1A mRNA expressions was followed by a rise of lymphocytes, monocytes, and granulocytes exhibiting activated phenotypes in blood. Monocytes showed elevated expression rates of CD11b, CD14 and MHC class II. The rates of CD62L expression on CD8hi T cells in blood and on CD4+ T cells in BALF were also augmented and peaked between 2 and 4 dpi. Notably, CD25 antigen expression was significantly elevated, not only on CD8dim/CD62L+ and CD8-/CD62L+ cells in blood, but also on granulocytes in blood and BALF between 2–3 dpi. From 4 dpi onwards, changes declined and the calves recovered from the infection until 10 dpi. The findings highlight the effectiveness of rapid local and systemic immune reaction and indicate activated T cells, monocytes and granulocytes being essential for rapid eradication of the C. psittaci infection.</p>
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<div id="c4590" class="csc-frame csc-frame-rulerAfter">
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<h4>Development of a multiplex fluorescence immunological assay for the simultaneous detection of antibodies against Cooperia oncophora, Dictyocaulus viviparus and Fasciola hepatica in cattle</h4>
</blockquote>
<div>
<p class="bodytext">Karanikola et al. <a class="external-link-new-window" title="Öffnet einen externen Link in einem neuen Fenster" href="https://parasitesandvectors.biomedcentral.com/" target="_blank" rel="noopener">Parasites &amp; Vectors</a> (2015) 8:335</p>
</div>
<div>
<p class="bodytext"><a class="external-link-new-window" title="Öffnet einen externen Link in einem neuen Fenster" href="https://www.researchgate.net/publication/278791778_Development_of_a_multiplex_fluorescence_immunological_assay_for_the_simultaneous_detection_of_antibodies_against_Cooperia_oncophora_Dictyocaulus_viviparus_and_Fasciola_hepatica_in_cattle" target="_blank" rel="noopener">DOI10.1186/s13071-015-0924-0</a></p>
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<p class="bodytext">(Sofia N. Karanikola, Jürgen Krücken, Sabrina Ramünke, Theo de Waal, Johan Höglund, Johannes Charlier, Corinna Weber, Elisabeth Müller, Slawomir J.Kowalczyk, Jaroslaw Kaba, Georg von Samson-Himmelstjerna and Janina Demeler)</p>
<p><b>Abstract</b></p>
<p>A major constraint for the effective control and management of helminth parasites is the lack of rapid, high-throughput, routine diagnostic tests to assess the health status of individual animals and herds and to identify the parasite species responsible for these helminthoses. The capability of a multiplex platform for the simultaneous detection of three pasture associated parasite species was evaluated and compared to existing ELISAs. The recombinant antigens 14.2 kDa ES protein for Cooperia oncophora, major sperm protein for Dictyocaulus viviparus and Cathepsin L1 for Fasciola hepatica were recombinantly expressed either in Escherichia coli or Pichia pastoris. Antigens were covalently coupled onto magnetic beads. Optimal concentrations for coupling were determined following the examination of serum samples collected from experimentally mono-infected animals, before and after their infection with the target species. Absence of cross-reactivity was further determined with sera from calves mono-infected with Haemonchus contortus, Ostertagia ostertagi and Trichostrongylus colubriformis. Examination of negative serum samples was characterised by low median fluorescence intensity (MFI). Establishment of the optimal serum dilution of 1:200 was achieved for all three bead sets. Receiver Operating Characteristic analyses were performed to obtain cut-off MFI values for each parasite separately. Sensitivity and specificity at the chosen cut-off values were close to, or 100 % for all bead sets. Examination of serum samples collected on different days post infection from different animals showed a high reproducibility of the assays. Serum samples were additionally examined with two already established ELISAs, an in-house ELISA using the recombinant MSP as an antigen and a DRG ELISA using Cathepsin L1 for liver fluke. The results between the assays were compared and kappa tests revealed an overall good agreement. A versatile bead-based assay using fluorescence detection (xMAP® technology) was developed to simultaneously detect antibodies against C. oncophora, D. viviparus and F. hepatica in cattle serum samples. This platform provides rapid, high-throughput results and is highly sensitive and specific in comparison to existing serological as well as coproscopical diagnostic techniques.</p>
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<div id="c4589" class="csc-frame csc-frame-rulerAfter">
<blockquote>
<h4>Detection of feline coronavirus spike gene mutations as a tool to diagnose feline infectious peritonitis</h4>
</blockquote>
<div>
<p class="bodytext"><a class="external-link-new-window" title="Öffnet einen externen Link in einem neuen Fenster" href="http://jfm.sagepub.com/content/early/2015/12/23/1098612X15623824" target="_blank" rel="noopener">Journal of Feline Medicine and Surgery</a> 2015 Dec 23   <a class="external-link-new-window" title="Öffnet einen externen Link in einem neuen Fenster" href="http://jfm.sagepub.com/content/early/2015/12/23/1098612X15623824" target="_blank" rel="noopener">DOI: 10.1177/1098612X15623824</a></p>
</div>
<div>
<p class="bodytext">(Felten S, Weider K, Doenges S, Gruendl S, Matiasek K, Hermanns W, Mueller E, Matiasek L, Fischer A, Weber K, Hirschberger J, Wess G, Hartmann K.)</p>
<p><b>Abstract</b></p>
<div>
<p class="bodytext"><b>OBJECTIVES</b>: Feline infectious peritonitis (FIP) is an important cause of death in the cat population worldwide. The ante-mortem diagnosis of FIP in clinical cases is still challenging. In cats without effusion, a definitive diagnosis can only be achieved post mortem or with invasive methods. The aim of this study was to evaluate the use of a combined reverse transcriptase nested polymerase chain reaction (RT-nPCR) and sequencing approach in the diagnosis of FIP, detecting mutations at two different nucleotide positions within the spike (S) gene.</p>
</div>
<div><b>METHODS</b>: The study population consisted of 64 cats with confirmed FIP and 63 cats in which FIP was initially suspected due to similar clinical or laboratory signs, but that were definitively diagnosed with another disease. Serum/plasma and/or effusion samples of these cats were examined for feline coronavirus (FCoV) RNA by RT-nPCR and, if positive, PCR products were sequenced for nucleotide transitions within the S gene.</div>
<div><b>RESULTS</b>: Specificity of RT-nPCR was 100% in all materials (95% confidence interval [CI] in serum/plasma 83.9-100.0; 95% CI in effusion 93.0-100.0). The specificity of the sequencing step could not be determined as none of the cats of the control group tested positive for FCoV RNA. Sensitivity of the &#8216;combined RT-nPCR and sequencing approach&#8217; was 6.5% (95% CI 0.8-21.4) in serum/plasma and 65.3% (95% CI 50.4-78.3) in effusion.</div>
<div><b>CONCLUSIONS AND RELEVANCE</b>: A positive result is highly indicative of the presence of FIP, but as none of the control cats tested positive by RT-nPCR, it was not possible to confirm that the FCoV mutant described can only be found in cats with FIP. Further studies are necessary to evaluate the usefulness of the sequencing step including FCoV-RNA-positive cats with and without FIP. A negative result cannot be used to exclude the disease, especially not when only serum/plasma samples are available.</div>
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<blockquote>
<h4>Herd-level seroprevalence of Neospora caninuminfectionin dairy cattle in central and northeastern Poland</h4>
</blockquote>
<div>
<p class="bodytext">W. Stefański Institute of Parasitology, PAS   <a class="external-link-new-window" title="Öffnet einen externen Link in einem neuen Fenster" href="https://www.degruyter.com/view/j/ap.2016.61.issue-1/ap-2016-0006/ap-2016-0006.xml" target="_blank" rel="noopener">DOI: 10.1515/ap-2016-0006</a></p>
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<div>
<p class="bodytext">Acta Parasitologica, 2016, 61(1), 63–65; ISSN 1230-2821</p>
</div>
<div></div>
<div>
<p class="bodytext">(Sławomir J. Kowalczyk, Michał Czopowicz, Corinna N. Weber, Elisabeth Müller, Lucjan Witkowski and Jarosław Kaba)</p>
<p><b>Abstract</b><br />
A serosurvey was carried out to estimate the herd-level seroprevalence of Neospora caninuminfection in cattle in central andnortheasternPoland. Ninety seven dairy cattle herds from 2 provinces of Poland (Podlaskie, 47 herds and Łódzkie, 50 herds)were randomly enrolled in the study using two-stage cluster method. A simple random selection was applied within each herdto select a sample of adult cows (≥18 month-old). A total number of 734 cows were enrolled in the study. The animals werescreened with a commercial competitive ELISA (Bio-X Diagnostics, Belgium). To calculate true herd-level seroprevalence testsensitivity and specificity were adjusted from an individual- to a herd-level using FreeCalc method. The true overall herd-levelseroprevalence of N. caninuminfection was 56.7% (95% CI: 47.5%, 65.9%). The true herd-level seroprevalence in Podlaskiewas 63.3% (95% CI: 43.0%, 83.6%) and 50.5% (95% CI: 32.8%, 68.2%) in Łódzkie province and these figures did not differsignificantly between the two provinces (chi2test p = 0.238). One hundred forty three of 734 cows (19.5%) were seropositivewhich gave the true overall individual-level seroprevalence of 20.1% (95% CI: 17.4%, 23.2%). Percentage of seropositivecows in each herd varied from 6% to 80%. This study is the first epidemiological investigation of herd-level seroprevalence ofN. caninuminfection in Polish dairy cattle population. In conclusion, the result of the study confirmed previous data that N. can-inuminfection is widespread in the Polish cattle population and thus should be considered as a potential cause of spontaneousabortions.</p>
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<p>&nbsp;</p>
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<div id="c4587" class="csc-frame csc-frame-rulerAfter">
<blockquote>
<h4>Encephalitozoon cuniculi causes focal anterior cataract and uveitis in dogs</h4>
</blockquote>
<div>
<p class="bodytext">Journal: Tierärztliche Praxis Kleintiere, Heft 5 2015 ; p.337-344</p>
</div>
<div>
<p class="bodytext">dx.doi.org/10.15654/TPK-141053</p>
</div>
<div>
<p class="bodytext"><a class="external-link-new-window" title="Öffnet einen externen Link in einem neuen Fenster" href="http://tpk.schattauer.de/en/contents/archive/issue/2272/manuscript/24848.html" target="_blank" rel="noopener">http://tpk.schattauer.de/en/contents/archive/issue/2272/manuscript/24848.html</a></p>
</div>
<div>
<p class="bodytext">(B. Nell, J. Csokai, A. Fuchs-Baumgartinger, G. Maaß)</p>
<p><b>Abstract</b><br />
Three mongrel dogs, aged 10 months (case 1), 14 months (case 2) and 7.5 years (case 3), were presented because of ophthalmologic disorders of 4 months, 6 months and 7 years duration, respectively. All three dogs were offspring of stray dogs from Hungary and Serbia and had positive serum antibody titres against Encephalitozoon (E.) cuniculi. The two young dogs showed unilateral, the older dog bilateral chronic anterior uveitis with posterior synechia and focal anterior cortical cataract. The fundi that could be evaluated developed focal tapetal hyporeflective lesions in the course of the disease. Dogs 1 and 2 underwent removal of the lens via phacoemulsification. PCR of the lens material was positive for E. cuniculi strains IV and II, respectively. In dog 2 findings suggestive of microsporidia were detected underneath the anterior lens capsule by immunohistochemical staining. In all cases medical treatment consisted of systemic fenbendazole, prednisolone, and topical anti-inflammatory drugs, and additional brinzolamid/timolol for dog 3. For the time being all cases (follow up 23 months, 6 months and 3 months, respectively) are still on topical anti-inflammatory therapy. It is concluded that E. cuniculi infections can cause cataract and chorioretinal lesions in dogs.</p>
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<blockquote>
<h4>Identification of snake arenaviruses in live boas and pythons in a zoo in Germany</h4>
</blockquote>
<div>
<p class="bodytext">(T. Aqrawi; A. C. Stöhr; T. Knauf-Witzens; A. Krengel; K. O. Heckers; R. E. Marschang)</p>
</div>
<div>
<p class="bodytext">Tierärztliche Praxis Kleintiere, (4-2015) Volume 43</p>
</div>
<div>
<p class="bodytext"><a href="http://dx.doi.org/10.15654/TPK-140743" target="_blank" rel="noopener">dx.doi.org/10.15654/TPK-140743</a></p>
<p><b>Summary</b><br />
Objective: Recent studies have described the detection and characterisation of new, snake specific arenaviruses in boas and pythons with inclusion body disease (IBD). The objective of this study was to detect arenaviral RNA in live snakes and to determine if these were associated with IBD in all cases. Samples for arenavirus detection in live aniated with IBD in all cases. Samples for arenavirus detection in live animals were compared. Detected viruses were compared in order to understand their genetic variability.</p>
<p><a class="download" title="Startet den Datei-Download" href="https://laboklin.com/fileadmin/FILES/Downloads/Publikationen/english/2015/TPK140074_Aqrawi.pdf" target="_blank" rel="noopener">PDF Download &gt;&gt;</a></p>
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<p>&nbsp;</p>
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<div id="c4585" class="csc-frame csc-frame-rulerAfter">
<blockquote>
<h4>Detection of Bacteria in Oral Swabs from Healthy Common Musk Turtles (Sternotherus odoratus) and West African Mud Turtles (Pelusios castaneus)</h4>
</blockquote>
<div>
<p class="bodytext">Journal of Herpetological Medicine and Surgery Volume 25, No. 1–2, 2015; P.33-39</p>
</div>
<div>
<p class="bodytext"><a class="external-link-new-window" title="Öffnet einen externen Link in einem neuen Fenster" href="http://jherpmedsurg.com/doi/pdf/10.5818/1529-9651-25.1.33" target="_blank" rel="noopener">http://jherpmedsurg.com/doi/pdf/10.5818/1529-9651-25.1.33</a></p>
</div>
<div>
<p class="bodytext">(Verena Heynol, Kim O. Heckers, Helge Behncke, Anton Heusinger, Rachel E. Marschang)</p>
<p><b>Abstract</b><br />
The bacterial flora of clinically healthy reptiles can be extremely diverse. The objectives of this study were to determine the bacterial flora in oral swabs from two different species of water turtles and to study growth characteristics and antibiotic resistance of these isolates. Oral swabs were collected from 20 clinically healthy common musk turtles (Sternotherus odoratus) and 20 West African mud turtles (Pelusios castaneus) and incubated at two different temperatures (25 and 37°C; 77.0 and 98.6°F) on various agar plates. All isolates were tested for susceptibility to a panel of antibiotics. A total of 66 distinct bacterial types were collected, 63 (95.45%, 95% confidence interval [CI]: 90–100) of which were Gram negative and 3 (4.55%, 95% CI: 0–27) of which were Gram positive. The most commonly isolated genera were Citrobacter spp. (in 97.5% of the animals tested, 95% CI: 93–100), Aeromonas spp. (in 92.5% of the animals tested, 95% CI: 84–100), Chryseobacterium spp. (in 80% of the animals tested, 95% CI: 68–92), and Salmonella spp. (in 80% of the animals tested, 95% CI: 68–92). The most commonly isolated bacterium was Aeromonas hydrophila (77.5%, 95% CI: 65–90). The oral bacterial flora of all of the examined animals consisted of a wide mixture of bacteria, many of which were potential pathogens. The combination of bacteria detected differed between individual animals. Incubation at 25 and 37°C led to the detection of distinct populations of bacteria. The resistance testing showed that many of the bacteria detected were resistant to a wide range of antibiotics.</p>
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<p>&nbsp;</p>
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<div id="c4584" class="csc-frame csc-frame-rulerAfter">
<blockquote>
<h4>Sequencing and phylogenetic analysis identifies candidate members of a new picornavirus genus in terrestrial tortoise species</h4>
</blockquote>
<div>
<p class="bodytext">Arch Virol. 160, 2015: Springer-Verlag Wien 811-816</p>
</div>
<div>
<p class="bodytext"><a class="external-link-new-window" title="Öffnet einen externen Link in einem neuen Fenster" href="http://www.ncbi.nlm.nih.gov/pubmed/25430906" target="_blank" rel="noopener">DOI 10.1007/s00705-014-2292-z</a></p>
</div>
<div>
<p class="bodytext">(Farkas SL, Ihász K, Fehér E, Bartha D, Jakab F, Gál J, Bányai K, Marschang RE)</p>
<p><b>Abstract</b><br />
Near-complete genome sequences of seven picornavirus (PV) strains isolated from different terrestrial tortoise species were determined and characterized. The genome organization of the strains proved to be similar and displayed a typical PV layout, and the polyprotein-encoding regions showed low similarity to those of other PVs. The predicted regions of the tortoise PV genomes were related to the corresponding genome parts of viruses belonging to distinct genera, implying modular evolution of these novel viruses. Our results suggest that these tortoise PVs belong to a prototype species in a separate proposed genus in the family Picornaviridae, tentatively called Topivirus (Tortoise picornavirus).</p>
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<p>&nbsp;</p>
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<div id="c4583" class="csc-frame csc-frame-rulerAfter">
<blockquote>
<h4>Detection of a new alphaherpesvirus in West African mud turtles (Pelusios castaneus)</h4>
</blockquote>
<div>
<p class="bodytext">Proceedings 2nd ICARE Paris, France, 18.-23. April 2015.</p>
</div>
<div>
<p class="bodytext">(Marschang R, Heckers K, Heynol V, Weider K, Behncke H.)</p>
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<p>&nbsp;</p>
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</div>
<div id="c4582" class="csc-frame csc-frame-rulerAfter">
<blockquote>
<h4>Complete sequencing of ranavirsues detected in European reptiles</h4>
</blockquote>
<div>
<p class="bodytext">Proceedings 2nd ICARE Paris, France, 18.-23. April 2015.</p>
</div>
<div>
<p class="bodytext">(Stöhr AC, López-Bueno A, Blahak S, Herberg AA, Marschang RE.)</p>
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<p>&nbsp;</p>
</div>
</div>
<div id="c4581" class="csc-frame csc-frame-rulerAfter">
<blockquote>
<h4>Formal pathogenesis and virus distribution after experimental infection of corn snakes with a ferlavirus</h4>
</blockquote>
<div>
<p class="bodytext">Proceedings 2nd ICARE Paris, France, 18.-23. April 2015.</p>
</div>
<div>
<p class="bodytext">(Pees M, Neul A, Plenz B, Truyen U, Leinecker N, Marschang RE, Starck M, Müller K, Schmidt V)</p>
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<p>&nbsp;</p>
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</div>
<div id="c4580" class="csc-frame csc-frame-rulerAfter">
<blockquote>
<h4>Detection of arenaviruses in live snakes</h4>
</blockquote>
<div>
<p class="bodytext">Farkas Proceedings 2nd ICARE Paris, France, 18.-23. April 2015.</p>
</div>
<div>
<p class="bodytext">(Marschang RE, Kolesnik E, Aqrawi T, Diez J, Heckers KO)</p>
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<p>&nbsp;</p>
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</div>
<div id="c4579" class="csc-frame csc-frame-rulerAfter">
<blockquote>
<h4>Distribution and Host Range of Ranaviruses</h4>
</blockquote>
<div>
<p class="bodytext">Gray MJ, Chinchar VG (eds.). Ranaviruses: Lethal Pathogens of Ectothermic Vertebrates.</p>
</div>
<div>
<p class="bodytext"><a class="external-link-new-window" title="Öffnet einen externen Link in einem neuen Fenster" href="http://link.springer.com/book/10.1007%2F978-3-319-13755-1" target="_blank" rel="noopener">SpringerOpen</a>. DOI 10.1007/978-3-319-13755-1. Pp. 9-58.</p>
</div>
<div>
<p class="bodytext">(Duffus ALJ, Waltzek TB, Stöhr AC, Allender MC, Gotesman M, Whittington RJ, Hick P, Hines MK, Marschang RE)</p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
</div>
</div>
<div id="c4578" class="csc-frame csc-frame-rulerAfter">
<blockquote>
<h4>Greek tortoises – Testudos don’t need tob e all Greek to you</h4>
</blockquote>
<div>
<p class="bodytext">Proceedings of the NAVC Conference Volume 29,</p>
</div>
<div>
<p class="bodytext">Orlando, Florida, USA, 17.-21. January 2015.</p>
</div>
<div>
<p class="bodytext">(Marschang RE)</p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
</div>
</div>
<div id="c4577" class="csc-frame csc-frame-rulerAfter">
<blockquote>
<h4>Why the dead crickets matter – invertebrate iridoviruses in reptiles and amphibians</h4>
</blockquote>
<div>
<p class="bodytext">Proceedings of the NAVC Conference Volume 29,</p>
</div>
<div>
<p class="bodytext">Orlando, Florida, USA, 17.-21. January 2015.</p>
</div>
<div>
<p class="bodytext">(Marschang RE)</p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
</div>
</div>
<div id="c4576" class="csc-frame csc-frame-rulerAfter">
<blockquote>
<h4>The 411 on inclusion body disease – what you need to know</h4>
</blockquote>
<div>
<p class="bodytext">Proceedings of the NAVC Conference Volume 29,</p>
</div>
<div>
<p class="bodytext">Orlando, Florida, USA, 17.-21. January 2015.</p>
</div>
<div>
<p class="bodytext">(Marschang RE)</p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
</div>
</div>
<div id="c4575" class="csc-frame csc-frame-rulerAfter">
<blockquote>
<h4>Reptile Virology – understanding it and how to make it profitable for your practice</h4>
</blockquote>
<div>
<p class="bodytext">Proceedings of the NAVC Conference Volume 29,</p>
</div>
<div>
<p class="bodytext">Orlando, Florida, USA, 17.-21. January 2015.</p>
</div>
<div>
<p class="bodytext">(Wellehan JFX, Marschang RE)</p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
</div>
</div>
<div id="c4574" class="csc-default">
<blockquote>
<h4>Phyologeny and differentiation of reptilian and amphibian ranaviruses detected in Europe</h4>
</blockquote>
<div>
<p class="bodytext">(Stöhr AC, López-Bueno A, Blahak S, Caeiro MF, Rosa GM, Alves de Matos AP, Martel A, Alejo A, Marschang RE.)</p>
</div>
<div>
<p class="bodytext">PLOS ONE 10(2) 2015: e0118633. doi:10.1371/journal.pone.0118633</p>
<div class="hr-thin"></div>
<p>&nbsp;</p>
</div>
</div>

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