{"id":1513835,"date":"2023-11-06T11:58:31","date_gmt":"2023-11-06T10:58:31","guid":{"rendered":"https:\/\/laboklin.com\/clinical-consensus-statements-and-guidelines-on-the-general-use-of-antibiotics-for-infectious-diseases\/"},"modified":"2024-08-01T14:29:25","modified_gmt":"2024-08-01T12:29:25","slug":"clinical-consensus-statements-and-guidelines-on-the-general-use-of-antibiotics-for-infectious-diseases","status":"publish","type":"post","link":"https:\/\/laboklin.com\/ch-it\/clinical-consensus-statements-and-guidelines-on-the-general-use-of-antibiotics-for-infectious-diseases\/","title":{"rendered":"Clinical consensus statements and guidelines on the general use of antibiotics for infectious diseases"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column width=&#8221;2\/3&#8243;][vc_column_text css=&#8221;&#8221;]<\/p>\n<h2>Definition of terms<\/h2>\n<p>Clinical consensus statements and guidelines are recognised medical statements and guidelines issued by a committee of experts.<\/p>\n<p>Consensus statements on pathophysiology, clinical guidelines for the diagnosis and therapy of common clinical presentations are important in both veterinary and human medicine. These are compiled on the basis of evidence-based medicine and commented on where necessary. A com\u00admittee of experts in the respective fields, as well as members of various specialist organisations prepare a draft, which is then submitted to a journal and undergoes a peer review process.<\/p>\n<p>After reviewing the content, consensus statements or clinical guidelines are then published. The authors are responsible for the content of these statements.<\/p>\n<h2>Professional organisations<\/h2>\n<p>Consensus statements and clinical guidelines are issued in many areas of veterinary medicine and by various international and national professional organisations. Table 1 lists some organisations in the field of small animal medicine that issue and\/or collect consensus statements and publish them on their websites. The list is by no means exhaustive, but summarises important publishers in the field of infectious diseases in small animals. Most consensus statements are freely available online via &#8220;PubMed&#8221; or other search engines (open access) and do not require licenced library access.[\/vc_column_text][\/vc_column][vc_column width=&#8221;1\/3&#8243;][vc_column_text css=&#8221;&#8221;]<\/p>\n\n\t\t\t<style type='text\/css'>\n\t\t\t\t#gallery-1 {\n\t\t\t\t\tmargin: auto;\n\t\t\t\t}\n\t\t\t\t#gallery-1 .gallery-item {\n\t\t\t\t\tfloat: left;\n\t\t\t\t\tmargin-top: 10px;\n\t\t\t\t\ttext-align: center;\n\t\t\t\t\twidth: 100%;\n\t\t\t\t}\n\t\t\t\t#gallery-1 img {\n\t\t\t\t\tborder: 2px solid #cfcfcf;\n\t\t\t\t}\n\t\t\t\t#gallery-1 .gallery-caption {\n\t\t\t\t\tmargin-left: 0;\n\t\t\t\t}\n\t\t\t\t\/* see gallery_shortcode() in wp-includes\/media.php *\/\n\t\t\t<\/style>\n\t\t<div id='gallery-1' class='dt-gallery-container gallery galleryid-1513835 gallery-columns-1 gallery-size-full'><dl class='gallery-item'>\n\t\t\t\t<dt class='gallery-icon landscape'>\n\t\t\t\t\t<a class=\"rollover rollover-zoom dt-pswp-item\" title=\"\" data-dt-img-description=\"LABOKLIN aktuell | &lt;b&gt;Fig. 1:&lt;\/b&gt; FECAVA poster with recommendations for antimicrobial therapy &lt;br&gt;&lt;i&gt; Image source: FECAVA&lt;\/i&gt;\" data-large_image_width=\"2000\" data-large_image_height=\"1414\"href='https:\/\/laboklin.com\/wp-content\/uploads\/2024\/07\/FECAVA_Recommendations_for_Appropriate_Antimicrobial_Therapy.jpg'><img loading=\"lazy\" decoding=\"async\" width=\"2000\" height=\"1414\" src=\"https:\/\/laboklin.com\/wp-content\/uploads\/2024\/07\/FECAVA_Recommendations_for_Appropriate_Antimicrobial_Therapy.jpg\" class=\"attachment-full size-full\" alt=\"\" aria-describedby=\"gallery-1-1513622\" srcset=\"https:\/\/laboklin.com\/wp-content\/uploads\/2024\/07\/FECAVA_Recommendations_for_Appropriate_Antimicrobial_Therapy.jpg 2000w, https:\/\/laboklin.com\/wp-content\/uploads\/2024\/07\/FECAVA_Recommendations_for_Appropriate_Antimicrobial_Therapy-300x212.jpg 300w, https:\/\/laboklin.com\/wp-content\/uploads\/2024\/07\/FECAVA_Recommendations_for_Appropriate_Antimicrobial_Therapy-1024x724.jpg 1024w, https:\/\/laboklin.com\/wp-content\/uploads\/2024\/07\/FECAVA_Recommendations_for_Appropriate_Antimicrobial_Therapy-768x543.jpg 768w, https:\/\/laboklin.com\/wp-content\/uploads\/2024\/07\/FECAVA_Recommendations_for_Appropriate_Antimicrobial_Therapy-1536x1086.jpg 1536w\" sizes=\"auto, (max-width: 2000px) 100vw, 2000px\" \/><\/a>\n\t\t\t\t<\/dt>\n\t\t\t\t\t<dd class='wp-caption-text gallery-caption' id='gallery-1-1513622'>\n\t\t\t\t\t<b>Fig. 1:<\/b> FECAVA poster with recommendations for antimicrobial therapy <br><i> Image source: FECAVA<\/i>\n\t\t\t\t\t<\/dd><\/dl><br style=\"clear: both\" \/><dl class='gallery-item'>\n\t\t\t\t<dt class='gallery-icon landscape'>\n\t\t\t\t\t<a class=\"rollover rollover-zoom dt-pswp-item\" title=\"\" data-dt-img-description=\"LABOKLIN aktuell | &lt;b&gt;Fig. 2:&lt;\/b&gt; Common cystitis pathogen Escherichia coli on endo agar and Staphylococcus pseudintermedius on sheep&#039;s blood agar &lt;br&gt;&lt;i&gt;Image source: Laboklin&lt;\/i&gt;\" data-large_image_width=\"1056\" data-large_image_height=\"579\"href='https:\/\/laboklin.com\/wp-content\/uploads\/2024\/07\/Endo-Agar_Shepps_blood_agar.jpg'><img loading=\"lazy\" decoding=\"async\" width=\"1056\" height=\"579\" src=\"https:\/\/laboklin.com\/wp-content\/uploads\/2024\/07\/Endo-Agar_Shepps_blood_agar.jpg\" class=\"attachment-full size-full\" alt=\"\" aria-describedby=\"gallery-1-1513639\" srcset=\"https:\/\/laboklin.com\/wp-content\/uploads\/2024\/07\/Endo-Agar_Shepps_blood_agar.jpg 1056w, https:\/\/laboklin.com\/wp-content\/uploads\/2024\/07\/Endo-Agar_Shepps_blood_agar-300x164.jpg 300w, https:\/\/laboklin.com\/wp-content\/uploads\/2024\/07\/Endo-Agar_Shepps_blood_agar-1024x561.jpg 1024w, https:\/\/laboklin.com\/wp-content\/uploads\/2024\/07\/Endo-Agar_Shepps_blood_agar-768x421.jpg 768w\" sizes=\"auto, (max-width: 1056px) 100vw, 1056px\" \/><\/a>\n\t\t\t\t<\/dt>\n\t\t\t\t\t<dd class='wp-caption-text gallery-caption' id='gallery-1-1513639'>\n\t\t\t\t\t<b>Fig. 2:<\/b> Common cystitis pathogen Escherichia coli on endo agar and Staphylococcus pseudintermedius on sheep&#8217;s blood agar <br><i>Image source: Laboklin<\/i>\n\t\t\t\t\t<\/dd><\/dl><br style=\"clear: both\" \/>\n\t\t\t<\/div>\n\n<p>[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column css=&#8221;.vc_custom_1721642224351{margin-top: 10px !important;}&#8221;][vc_column_text css=&#8221;&#8221;]<strong>ACVIM<\/strong> (American Journal of Veterinary Internal Medicine) compiles numerous consensus statements. These mainly deal with internal diseases of small animal and equine medicine. However, their website also contains articles on infectious diseases in cattle. The consensus statements are published in the Journal of Veterinary Internal Medicine.<\/p>\n<p><strong>Table 1:<\/strong> Examples of professional organisations that draw up consensus statements<\/p>\n<table width=\"604\">\n<tbody valign=\"top\">\n<tr style=\"color: #ffffff;\" bgcolor=\"#e51e1e\">\n<td colspan=\"2\" width=\"308\"><strong>Specialis societies<\/strong><\/td>\n<td width=\"154\"><strong>Focal points<\/strong><\/td>\n<td width=\"141\"><strong>Predominant species<\/strong><\/td>\n<\/tr>\n<tr>\n<td width=\"128\"><strong>ACVIM<\/strong><\/td>\n<td width=\"181\">American College of Veterinary Internal Medicine<\/td>\n<td width=\"154\">Internal medicine<\/td>\n<td width=\"141\">Small animals, horses<\/td>\n<\/tr>\n<tr>\n<td width=\"128\"><strong>WSAVA<\/strong><\/td>\n<td width=\"181\">World Small Animal Veterinary Association<\/td>\n<td width=\"154\">Broadly diversified<\/td>\n<td width=\"141\">Small animals<\/td>\n<\/tr>\n<tr>\n<td width=\"128\"><strong>FECAVA<\/strong><\/td>\n<td width=\"181\">Federation of European Companion Animal Veterinary Associations<\/td>\n<td width=\"154\">Broadly diversified<\/td>\n<td width=\"141\">Small animals<\/td>\n<\/tr>\n<tr>\n<td width=\"128\"><strong>BSAVA<\/strong><\/td>\n<td width=\"181\">British Small Animal Veterinary Association<\/td>\n<td width=\"154\">Broadly diversified<\/td>\n<td width=\"141\">Small animals<\/td>\n<\/tr>\n<tr>\n<td width=\"128\"><strong>ISFM<\/strong><\/td>\n<td width=\"181\">International Society for Feline Medicine<\/td>\n<td width=\"154\">Cat medicine<\/td>\n<td width=\"141\">Cats<\/td>\n<\/tr>\n<tr>\n<td width=\"128\"><strong>ISCAID<\/strong><\/td>\n<td width=\"181\">International Society for Companion Animal Infectious Diseases<\/td>\n<td width=\"154\">Infectious diseases<\/td>\n<td width=\"141\">Small animals<\/td>\n<\/tr>\n<tr>\n<td width=\"128\"><strong>ESCCAP<\/strong><\/td>\n<td width=\"181\">European Scientific Counsel Companion Animal Parasites<\/td>\n<td width=\"154\">Parasites, dermatophytes<\/td>\n<td width=\"141\">Small animals, horses<\/td>\n<\/tr>\n<tr>\n<td width=\"128\"><strong>BTK<\/strong><\/td>\n<td width=\"181\">Bundestier\u00e4rztekammer<\/td>\n<td width=\"154\">Broadly diversified, antibiotic guidelines<\/td>\n<td width=\"141\">Small animals, horses, farm animals, etc.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<p><strong>FECAVA<\/strong> (Federation of European Companion Animal Veterinary Associations) is the overarching European organisation in the field of small animal veterinary medicine maintains a list of consensus statements on its website and provides overview posters for veterinarians (Figure 1) on the use of antimicrobial agents in common infectious diseases and information material for animal owners on the subject of infectious diseases, antibiotic therapy and hygiene. The posters and information material can be ordered in German from LABOKLIN.<\/p>\n<p>The <strong>BSAVA<\/strong> (British Small Animal Veterinary Association), in collaboration with <strong>SAMSoc<\/strong> (Small Animal Medicine Society), published a book on the responsible use of antibiotics in combination with two posters on diagnostics and empirical therapy for common infectious diseases. &#8220;PROTECT ME&#8221;, the BSAVA\/SAMSoc Guide to Responsible Use of Antibacterials, is a comprehensive reference work on the subject of antibiotics in general as well as specifically focussing on diseases that are frequently encountered in veterinary practice. For example, it includes chapters on bacterial eye infections, gastrointestinal infections and urinary tract infections.<\/p>\n<p>At national level in Germany, the <strong>BTK<\/strong> (German Veterinary Association) issues guidelines on a wide range of veterinary activities. In the field of infection medicine, everyone should be familiar with the antibiotic guidelines.<\/p>\n<p>The Antimicrobial Working Group of the <strong>ISCAID<\/strong> (International Society for Companion Animal Infectious Diseases) develops consensus statements and guidelines specifically for infectious diseases and their management and treatment in small animals. The ISCAID consensus statements for common infectious diseases in dogs and cats are briefly presented below. As with all guidelines, they represent recommendations that have been developed from the point of view of good veterinary practice and cover many cases from practice, but can never represent all clinical disease patterns equally.<\/p>\n<h2>ISCAID guidelines on the management and treatment of infectious diseases<\/h2>\n<p><strong>1. Handling antimicrobial agents \u2012 antibiotic stewardship<\/strong><\/p>\n<p>Given the background of antibiotic resistance and multi-resistant germs, the conscious and sparing use of antibiotics is more important than ever in order to maintain their effectiveness in the future. Guidelines on the use of antibiotics in small animal practice (antibiotic stewardship) have therefore been defined to help practitioners provide patients with successful treatment on the one hand and avoid the development of resistance on the other. These guidelines include willingness to participate, prophylactic measures such as vaccinations, the conscious selection and use of antibiotics, the development of treatment plans and the development and sharing of knowledge. The creation of a practice&#8217;s own resistance monitoring programme can also be part of antibiotic stewardship.<\/p>\n<p><strong>2. Infections of the urogenital tract<\/strong><\/p>\n<p>The current guidelines on urinary tract infections were published in 2019. In contrast to the previous guidelines from 2011, infections of the urogenital tract are categorised into sporadic bacterial cystitis, recurrent bacterial cystitis, pyelonephritis and bacterial prostatitis. The topics of subclinical bacteriuria, urinary catheters, surgical interventions on the urogenital tract and drug dissolution of urinary stones are also covered. The most common cystitis pathogens are Escherichia coli (Figure 2), other enterobacteria such as Proteus mirabilis and coagulase-positive staphylococci such as Staphylococcus aureus and Staphylococcus pseudintermedius (Figure 2).<\/p>\n<p>The guidelines classify each clinical picture, then provide recommendations for diagnosis and treatment, followed by information on patient follow-up.<\/p>\n<p>Sporadic bacterial cystitis occurs frequently in dogs and less frequently in cats. In veterinary practice, they are often an indication for the use of antibiotics.<\/p>\n<p>In the new guidelines, a shorter course of antibiotics is recommended for most of the clinical pictures described. In the case of sporadically occurring cystitis, initial treatment with antibiotics should be avoided; treatment with anti-inflammatory drugs is recommended in the first instance. Subsequently, antimicrobial therapy is started for 3 to 5 days after the results of the cultural examination and if the clinical symptoms persist. Amoxicillin and trimethoprim\/sulphonamide are the first choice. In the case of pyelonephritis and bacterial prostatitis, it is important to inform the laboratory of the sampling location, as different evaluation criteria are involved.<\/p>\n<p><strong>3. Respiratory tract infections<\/strong><\/p>\n<p>In veterinary practice, dogs and cats frequently present with respiratory infections. The ISCAID guidelines describe various diseases such as acute and chronic upper respiratory tract infections, bacterial bronchitis, pneumonia and pyothorax. For each disease complex, the causative pathogens and suitable samples for diagnosis are described and treatment recommendations are given. Doxycycline is mentioned as the first choice for many bacterial diseases of the respiratory tract in dogs and cats.<\/p>\n<p><strong>4. Dermatology<\/strong><\/p>\n<p>The guidelines for superficial folliculitis and pyoderma in dogs date from 2014 and are currently being revised. Guidelines on dermatophytes and malassezia are also available. The main pathogen in canine superficial folliculitis and pyoderma is Staphylococcus pseudintermedius. Local therapy with antiseptic preparations is primarily recommended. Clindamycin, 1st generation cephalosporins such as cefalexin, amoxicillin-clavulanic acid and trimethoprim\/sulphonamide are recommended as the empirical antibiotics of choice for systemic therapy.<\/p>\n<h2>Prohibitions on the use of certain antimicrobial agents in animals<\/h2>\n<p>In February 2023, new legislation (Implementing Regulation EU 2022\/1255) came into force at European level, which bans the use of certain antimicrobial agents (antibiotics and antivirals) and antiparasitics in animals, as these agents are to be reserved exclusively for human medicine. Among other things, active substances such as ticarcillin, piperacillin, meropenem and imipenem may no longer be used in animals.<\/p>\n<h2>Summary<\/h2>\n<p>Clinical consensus statements and guidelines are valuable resources for veterinarians as they provide consolidated and standardised information along with expert opinion on the diagnosis and treatment of common diseases in veterinary medicine. Consensus statements are usually available online free of charge. There are overview posters available for the most common infectious diseases in small animals, which cover the diagnostic procedure and empirical treatment.<\/p>\n<p style=\"text-align: right;\"><em>Dr. Marianne Schneider<\/em><\/p>\n<p>&nbsp;<\/p>\n<blockquote><p><strong>Our services relating to bacterial infectious diseases<\/strong><br \/>\n&#8211; <a href=\"https:\/\/laboklin.com\/ch-it\/products\/microbiology-parasitology\/bacteriology-mycology\/smears-aspirates-milk\/bacteriology-aerobes\/\" target=\"_blank\" rel=\"noopener\"><u>Aerobic<\/u><\/a> <span style=\"color: #000000;\">and\/or<\/span> <a href=\"https:\/\/laboklin.com\/ch-it\/products\/microbiology-parasitology\/bacteriology-mycology\/smears-aspirates-milk\/detection-of-anaerobes\/\" target=\"_blank\" rel=\"noopener\"><u>anaerobic bacteriology<\/u><\/a><br \/>\n&#8211; <a href=\"https:\/\/laboklin.com\/ch-it\/products\/microbiology-parasitology\/bacteriology-mycology\/susceptibility-testing\/antibiogram\/\" target=\"_blank\" rel=\"noopener\"><u>Antibiogram for aerobic<\/u><\/a> <span style=\"color: #000000;\">and\/or<\/span> <a href=\"https:\/\/laboklin.com\/ch-it\/products\/microbiology-parasitology\/bacteriology-mycology\/susceptibility-testing\/antibiogram-anaerobes\/\" target=\"_blank\" rel=\"noopener\"><u>anaerobic germs<\/u><\/a><br \/>\n&#8211; <span style=\"color: #000000;\">Testing for<\/span> <a href=\"https:\/\/laboklin.com\/ch-it\/products\/microbiology-parasitology\/bacteriology-mycology\/testing-for-specific-infectious-agents\/analysis-on-multidrug-resistant-bacteria\/\" target=\"_blank\" rel=\"noopener\"><u>multi-resistant germs<\/u><\/a><br \/>\n&#8211; <a href=\"https:\/\/laboklin.com\/ch-it\/products\/microbiology-parasitology\/bacteriology-mycology\/smears-aspirates-milk\/blood-culture\/\" target=\"_blank\" rel=\"noopener\"><u>Blood cultures<\/u><\/a><br \/>\n&#8211; <a href=\"https:\/\/laboklin.com\/ch-it\/products\/infectious-diseases-pathogens-and-antibody-detection\/\" target=\"_blank\" rel=\"noopener\"><u>Numerous direct pathogen detections by means of PCR<\/u><\/a><br \/>\n&#8211; <a href=\"https:\/\/laboklin.com\/ch-it\/products\/microbiology-parasitology\/bacteriology-mycology\/susceptibility-testing\/aromatogram-bacteria\/\" target=\"_blank\" rel=\"noopener\"><u>Aromatograms<\/u><\/a>, <a href=\"https:\/\/laboklin.com\/ch-it\/products\/microbiology-parasitology\/autovaccine-herd-specific-vaccine\/\" target=\"_blank\" rel=\"noopener\"><u>autovaccines<\/u><\/a><br \/>\n&#8211; <span style=\"color: #000000;\">and many more&#8230;<\/span><\/p><\/blockquote>\n<p>[\/vc_column_text][\/vc_column][\/vc_row][vc_row type=&#8221;vc_default&#8221; gap=&#8221;10&#8243; equal_height=&#8221;yes&#8221; css=&#8221;.vc_custom_1721726861902{margin-top: 30px !important;}&#8221;][vc_column][vc_column_text css=&#8221;&#8221;]<\/p>\n<h5><strong>Further literature:<\/strong><\/h5>\n<h6><span style=\"color: #808080;\"><strong>Frey E, Costin M, Granick J, Kornya M, Weese JS. 2022 AAFP\/AAHA Antimicrobial Stewardship Guidelines. J Am Anim Hosp Assoc. 2022 Jul 1;58(4):1-5. doi: 10.5326\/1547-3317-58.4.1.<\/strong><\/span><\/h6>\n<h6><span style=\"color: #808080;\"><strong>Hillier, Andrew; Lloyd, David H.; Weese, J. Scott; Blondeau, Joseph M.; Boothe, Dawn; Breitschwerdt, Edward et al. (2014): Guidelines for the diagnosis and antimicrobial therapy of canine superficial bacterial folliculitis (Antimicrobial Guidelines Working Group of the International Society for Companion Animal Infectious Diseases). In: Vet. Dermatol. 2014. 25 (3), 163-e43. DOI: 10.1111\/vde.12118.<\/strong><\/span><\/h6>\n<h6><span style=\"color: #808080;\"><strong>Lappin, M. R.; Blondeau, J.; Boothe, D.; Breitschwerdt, E. B.; Guardabassi, L.; Lloyd, D. H. et al. (2017): Antimicrobial use Guidelines for Treatment of Respiratory Tract Disease in Dogs and Cats: Antimicrobial Guidelines Working Group of the International Society for Companion Animal Infectious Diseases. In: J. Vet. Intern. Med. 2017, 31 (2), S. 279\u2013294. DOI: 10.1111\/jvim.14627.<\/strong><\/span><\/h6>\n<h6><span style=\"color: #808080;\"><strong>Morris DO, Loeffler A, Davis MF, Guardabassi L, Weese JS. Recommendations for approaches to meticillin-resistant staphylococcal infections of small animals: diagnosis, therapeutic considerations and preventative measures.: Clinical Consensus Guidelines of the World Association for Veterinary Dermatology. Vet Dermatol. 2017 Jun;28(3):304-e69. doi: 10.1111\/vde.12444.<\/strong><\/span><\/h6>\n<h6><span style=\"color: #808080;\"><strong>Weese JS, Gigu\u00e8re S, Guardabassi L, Morley PS, Papich M, Ricciuto DR, Sykes JE. ACVIM consensus statement on therapeutic antimicrobial use in animals and antimicrobial resistance. J Vet Intern Med. 2015;29(2):487-98. doi: 10.1111\/jvim.12562.<\/strong><\/span><\/h6>\n<h6><span style=\"color: #808080;\"><strong>Weese, JS. Scott; Blondeau, Joseph; Boothe, Dawn; Guardabassi, Luca G.; Gumley, Nigel; Papich, Mark et al. (2019): International Society for Companion Animal Infectious Diseases (ISCAID) guidelines for the diagnosis and management of bacterial urinary tract infections in dogs and cats. Vet. J. 2019: 247, S. 8\u201325. DOI: 10.1016\/j.tvjl.2019.02.008.<\/strong><\/span><\/h6>\n<p>[\/vc_column_text][\/vc_column][\/vc_row][vc_row type=&#8221;vc_default&#8221; gap=&#8221;10&#8243; equal_height=&#8221;yes&#8221; content_placement=&#8221;middle&#8221; css=&#8221;.vc_custom_1721728764145{margin-top: 30px !important;}&#8221;][vc_column width=&#8221;1\/6&#8243; css=&#8221;.vc_custom_1721726870152{background-color: #e7e7e7 !important;}&#8221;][vc_icon icon_fontawesome=&#8221;fas fa-file-pdf&#8221; color=&#8221;custom&#8221; size=&#8221;xl&#8221; align=&#8221;center&#8221; css=&#8221;.vc_custom_1721729177008{margin-top: 10px !important;margin-bottom: 10px !important;padding-top: 20px !important;padding-bottom: 20px !important;}&#8221; custom_color=&#8221;#e51e1e&#8221; link=&#8221;url:https%3A%2F%2Flaboklin.com%2Fwp-content%2Fuploads%2F2024%2F07%2FGuidelines_general_use_of_antibiotics.pdf|target:_blank&#8221;][\/vc_column][vc_column width=&#8221;5\/6&#8243; css=&#8221;.vc_custom_1721726885159{background-color: #e7e7e7 !important;}&#8221;][vc_column_text css=&#8221;.vc_custom_1721729204531{margin-top: 10px !important;margin-bottom: 10px !important;padding-top: 20px !important;padding-bottom: 20px !important;}&#8221;]<a href=\"https:\/\/laboklin.com\/wp-content\/uploads\/2024\/07\/Guidelines_general_use_of_antibiotics.pdf\" target=\"_blank\" rel=\"noopener\"><strong>Clinical consensus statements and guidelines on the general use of antibiotics for infectious diseases<\/strong><\/a>[\/vc_column_text][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Clinical consensus statements and guidelines are recognised medical statements and guidelines issued by a committee of experts. <\/p>\n","protected":false},"author":30,"featured_media":1513639,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_seopress_robots_primary_cat":"none","_seopress_titles_title":"%%post_title%%","_seopress_titles_desc":"%%post_excerpt%%","_seopress_robots_index":"","footnotes":""},"categories":[437],"tags":[],"table_tags":[],"class_list":["post-1513835","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-laboklin-aktuell-2023","category-437","description-off"],"_links":{"self":[{"href":"https:\/\/laboklin.com\/ch-it\/wp-json\/wp\/v2\/posts\/1513835","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/laboklin.com\/ch-it\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/laboklin.com\/ch-it\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/laboklin.com\/ch-it\/wp-json\/wp\/v2\/users\/30"}],"replies":[{"embeddable":true,"href":"https:\/\/laboklin.com\/ch-it\/wp-json\/wp\/v2\/comments?post=1513835"}],"version-history":[{"count":1,"href":"https:\/\/laboklin.com\/ch-it\/wp-json\/wp\/v2\/posts\/1513835\/revisions"}],"predecessor-version":[{"id":1514688,"href":"https:\/\/laboklin.com\/ch-it\/wp-json\/wp\/v2\/posts\/1513835\/revisions\/1514688"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/laboklin.com\/ch-it\/wp-json\/wp\/v2\/media\/1513639"}],"wp:attachment":[{"href":"https:\/\/laboklin.com\/ch-it\/wp-json\/wp\/v2\/media?parent=1513835"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/laboklin.com\/ch-it\/wp-json\/wp\/v2\/categories?post=1513835"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/laboklin.com\/ch-it\/wp-json\/wp\/v2\/tags?post=1513835"},{"taxonomy":"table_tags","embeddable":true,"href":"https:\/\/laboklin.com\/ch-it\/wp-json\/wp\/v2\/table_tags?post=1513835"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}