{"id":1432643,"date":"2022-09-06T10:55:10","date_gmt":"2022-09-06T08:55:10","guid":{"rendered":"https:\/\/staging-wp-int.laboklin.com\/products\/genetics\/hereditary-diseases\/dog\/severe-combined-immuno-deficiency-scid\/"},"modified":"2022-11-22T13:17:13","modified_gmt":"2022-11-22T12:17:13","slug":"severe-combined-immuno-deficiency-scid","status":"publish","type":"page","link":"https:\/\/laboklin.com\/ch-fr\/products\/genetics\/hereditary-diseases\/dog\/severe-combined-immuno-deficiency-scid\/","title":{"rendered":"Severe combined immuno deficiency (SCID)"},"content":{"rendered":"

Severe combined immuno deficiency (SCID)<\/h3>

LABOKLIN Service ID: 8328<\/span><\/p>

The severe combined immunodeficiency (SCID) is associated with very low levels of immunoglobulins and lymphocytes and therefore causes serious failing in cellular and humoral immunity. Affected dogs show increased susceptibility for viral and bacterial pathogens and die of opportunistic infection at the age of 8 \u2013 12 weeks. The causal mutation in Frisian Water Dogs is a point mutation in the RAG1 gene, while in Jack Russell Terriers there is a point mutation in the canine DNA-PKcs gene.<\/p>
Method<\/strong><\/td>

sequencing<\/p><\/td><\/tr>

Breed list<\/strong><\/td>

Frisian Water Dog, Jack Russell Terrier, Parson Russell Terrier<\/p><\/td><\/tr>

Heredity<\/strong><\/td>

autosomal recessive<\/p><\/td><\/tr>

Duration<\/strong><\/td>

1 - 2 weeks after arrival of the sample in the lab<\/p><\/td><\/tr><\/table>\n","protected":false},"excerpt":{"rendered":"

Severe combined immuno deficiency (SCID)LABOKLIN Service ID: 8328The severe combined immunodeficiency (SCID) is associated with very low levels of immunoglobulins and lymphocytes and therefore causes serious failing in cellular and humoral immunity. Affected dogs show increased susceptibility for viral and bacterial pathogens and die of opportunistic infection at the age of 8 \u2013 12 weeks.…<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":1419950,"menu_order":90,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_seopress_robots_primary_cat":"","_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","footnotes":""},"class_list":["post-1432643","page","type-page","status-publish","hentry","description-off"],"_links":{"self":[{"href":"https:\/\/laboklin.com\/ch-fr\/wp-json\/wp\/v2\/pages\/1432643","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/laboklin.com\/ch-fr\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/laboklin.com\/ch-fr\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/laboklin.com\/ch-fr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/laboklin.com\/ch-fr\/wp-json\/wp\/v2\/comments?post=1432643"}],"version-history":[{"count":0,"href":"https:\/\/laboklin.com\/ch-fr\/wp-json\/wp\/v2\/pages\/1432643\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/laboklin.com\/ch-fr\/wp-json\/wp\/v2\/pages\/1419950"}],"wp:attachment":[{"href":"https:\/\/laboklin.com\/ch-fr\/wp-json\/wp\/v2\/media?parent=1432643"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}